Patents by Inventor Wesley J. Dwight

Wesley J. Dwight has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gonadotropin-releasing hormone receptor antagonists and methods related thereto
    Patent number: 7419983
    Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: September 2, 2008
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Zhiqiang Guo, Yongsheng Chen, Dongpei Wu, Chen Chen, Warren Wade, Wesley J. Dwight, Charles Q. Huang, Fabio C. Tucci
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Patent number: 7176211
    Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: February 13, 2007
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Zhiqiang Guo, Yongsheng Chen, Dongpei Wu, Chen Chen, Warren Wade, Wesley J. Dwight, Charles Q. Huang, Fabio C. Tucci
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Patent number: 7056927
    Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: June 6, 2006
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Zhiqiang Guo, Yongsheng Chen, Dongpei Wu, Chen Chen, Warren Wade, Wesley J. Dwight, Charles Q. Huang, Fabio C. Tucci
  • 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
    Patent number: 6620839
    Abstract: Compounds of formula I are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands. Also disclosed are histamine-3 receptor ligand compositions and methods of antagonizing or agonizing histamine-3 receptors.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: September 16, 2003
    Assignee: Abbott Laboratories
    Inventors: Yousseff L. Bennani, Ramin Faghih, Wesley J. Dwight, Anil Vasudevan, Scott E. Conner
  • Cyclic and bicyclic diamino histamine-3 receptor antagonists
    Patent number: 6559140
    Abstract: Compounds of formula (I) compounds of formula (II) compounds of formula (III) and compounds of formula (IV) or pharmaceutically acceptable salts thereof are useful as H3 receptor antagonists. Processes to make the compounds and methods of treatment using the compounds are also disclosed.
    Type: Grant
    Filed: March 5, 2001
    Date of Patent: May 6, 2003
    Assignee: Abbott Laboratories
    Inventors: Youssef L. Bennani, Lawrence A. Black, Wesley J. Dwight, Ramin Faghih, Robert G. Gentles, Huaqing Liu, Kathleen M. Phelan, Anil Vasudevan, Henry Q. Zhang
  • 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
    Patent number: 6515013
    Abstract: Compounds of formula I are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands. Also disclosed are histamine-3 receptor ligand compositions and methods of antagonizing or agonizing histamine-3 receptors.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: February 4, 2003
    Assignee: Abbott Laboratories
    Inventors: Youssef L. Bennani, Ramin Faghih, Wesley J. Dwight, Anil Vasudevan, Scott E. Conner
  • 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
    Publication number: 20020137931
    Abstract: Compounds of formula I 1
    Type: Application
    Filed: January 11, 2002
    Publication date: September 26, 2002
    Inventors: Yousseff L. Bennani, Ramin Faghih, Wesley J. Dwight, Anil Vasudevan, Scott E. Conner
  • 1,3-Disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
    Publication number: 20020035103
    Abstract: Compounds of formula I 1
    Type: Application
    Filed: July 11, 2001
    Publication date: March 21, 2002
    Inventors: Youssef L. Bennani, Ramin Faghih, Wesley J. Dwight, Anil Vasudevan, Scott E. Conner
  • Cyclic and bicyclic diamino histamine-3 receptor antagonists
    Publication number: 20010049367
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: March 5, 2001
    Publication date: December 6, 2001
    Inventors: Youssef L. Bennani, Lawrence A. Black, Wesley J. Dwight, Ramin Faghih, Robert G. Gentles, Huaqing Liu, Kathleen M. Phelan, Anil Vasudevan, Henry Q. Zhang
  • C-terminus modified heptapeptide LHRH analogs
    Patent number: 6191115
    Abstract: The present invention relates to a class of heptapeptide analogs of LHRH. These compounds are useful in the treatment of disease conditions which are mediated by reproductive hormones, including benign prostate hyperplasia, prostate tumors, breast and ovaries tumors, cryptorchidism, hirsuitism, gastric motility disorders, dysmenorrhea, and endometriosis.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: February 20, 2001
    Assignee: Abbott Laboratories
    Inventors: Fortuna Haviv, Wesley J. Dwight, Charles J. Nichols, Jonathan Greer
  • Tetrahydroisoquinoline derivatives as LHRH antagonists
    Patent number: 5981521
    Abstract: Tetrahydroisoquinoline derivatives of the formula: ##STR1## or a pharmaceutically acceptable salt, ester, or prodrug thereof, having activity as an LHRH antagonist, as well as pharmaceutical compositions containing the same, and methods for their use and preparation.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: November 9, 1999
    Assignee: Abbott Laboratories
    Inventors: Fortuna Haviv, Wesley J. Dwight, Bradley W. Crawford, Rolf E. Swenson, Milan Bruncko, Michele A. Kaminski, Lisa M. Frey, John DeMattei, Jonathan Greer