Abstract: Devices and methods are presented whereby cryotherapy may be conducted with both an enhanced healing process and a reduced risk of collateral ischemic injury when compared with existing options. A cold effect is applied to an injured tissue for a sufficient time to lower the temperature sufficiently to suppress local pain and inflammation. In an alternating manner a warm effect is applied to the tissue at the same treatment site with sufficient intensity to raise the temperature at the treatment site to equal or exceed the baseline value for a sufficient time to cause an increase in local blood flow equal to or exceeding the baseline value, after which the cycle is repeated until therapy is no longer needed.