Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: W—X—Y—Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: An engine assembly is provided, the engine assembly comprising an engine cover configured to cover a portion of an engine housing. The engine cover comprises: a coupling region provided around a periphery of at least a portion of the engine cover, the coupling region configured to mate with a corresponding coupling region on the engine housing so as to form a seal between the engine cover and the engine housing, and an engine cover boss provided on a planar region of the engine cover and spaced apart from the coupling region, the engine cover boss comprising a contact surface configured to receive an adhesive to couple the engine cover to a corresponding contact surface of the engine housing.

Abstract: An engine assembly is provided, the engine assembly comprising an engine cover configured to cover a portion of an engine housing. The engine cover comprises: a coupling region provided around a periphery of at least a portion of the engine cover, the coupling region configured to mate with a corresponding coupling region on the engine housing so as to form a seal between the engine cover and the engine housing, and an engine cover boss provided on a planar region of the engine cover and spaced apart from the coupling region, the engine cover boss comprising a contact surface configured to receive an adhesive to couple the engine cover to a corresponding contact surface of the engine housing.