Abstract: Compounds useful as linker-payload compounds are disclosed. The compounds have the following Structure (I): as a stereoisomer, enantiomer or tautomer thereof or a mixture thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein X1, X2, X3, X4, X5, R4a, and R4b are as defined herein. Additional compounds, conjugates, methods of preparation, pharmaceutical compositions, and methods of treatment related to conjugates of compounds of Structure (I) and a targeting moiety, or binding fragment thereof, are also provided.

Abstract: The present disclosure relates to fuse multiple database tables together. The fields of the database tables may be normalized using semantic fields. Under a first approach, database tables are deduplicated by consolidating redundant records. This may be done by performing pairwise comparisons to identify related pairs of records and then clustering the related pairs of records. Then, the deduplicated database tables are merged by performing another pairwise comparison. Under a second approach, the database tables may be concatenated. Thereafter, records are subject to pairwise comparisons and then clustered to create a merged database table.

Abstract: Amino-pyrazinecarboxamide compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of cancer and fibrosis and modulating TGF?R2. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein.

Abstract: Provided are optical fiber alignment assemblies, comprising: a plurality of fiber channel members being arranged along a first vertical axis, each fiber channel member comprising a fiber channel configured to accommodate an optical fiber disposed therein, the plurality of fiber channels being parallel to one another, fiber channels adjacent to one another defining a spacing therebetween, the spacing being measured along the first vertical axis; a plurality of resilient members, a resilient member being disposed between adjacent fiber channel members; and an adjustment element, the adjustment element being configured to effect a force oriented along the first vertical axis, and the adjustment member being configured such that actuation of the adjustment member changes a compression of the plurality of resilient members so as to effect an essentially linear variation in the spacing between adjacent fiber channels. Also provided are related methods.

Abstract: Imidazoquinoline compounds of formula (IA), conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed imidazoquinoline compounds are useful, among other things, in the treating of cancer and modulating TLR7. Additionally, imidazoquinoline compounds incorporated into a conjugate with an antibody construct are described herein.

Abstract: Cyclic amino-pyrazinecarboxamide compounds, salts, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of disease, for example cancer and/or fibrotic diseases, and modulating TGF?R2.

Abstract: The invention is directed to recombinant bacteria, a recombinant plasmid, a pharmaceutical composition and a kit as well as the use of a reconstitution medium comprising chloride ions to reconstitute the recombinant bacteria.

Abstract: A system, apparatus, and method to provide a systematic assessment learning approach that is utilized through a computing device to determine its users sport IQ score for one or more sports is disclosed. The system includes a multi-dimensional, systematic learning assessment processor to correlate answered questions and compute the sport IQ-score. In some cases, the questions in the database may include videos of sport content and other associated sport content. The system presents a quantifiable metric of a user's performance potential in a sport and provides a learning program for developing the user's skills across multiple dimensions.

Abstract: Benzazepine compounds and salts thereof, conjugates and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed benzazepine compounds and salts thereof are useful, among other things, in treating of cancer and activating an immune response. Additionally, benzazepine compounds or salts thereof attached to an antibody construct to form an antibody conjugate are described herein.

Abstract: Systems and methods are described which manage, in real time, and without impeding the natural flow of vehicles, a preferred flow of traffic within a geographic location based on prior modeling and simulation.

Abstract: A replaceable tooth for a circular saw with a base and angled cutting surfaces defining nadirs of intersection between adjacent cutting surfaces. Inserts are provided to cover facets of the angled cutting surfaces of the replaceable tooth. Plugs of a hardened material are provided immediately below each nadir of intersection to prevent erosion of the tooth base below the intersections of the inserts.

Abstract: A replaceable tooth for a circular saw having a base and angled cutting surfaces defining nadirs of intersection between them and inserts covering the facets of the cutting surfaces. Plugs of a hardened material are provided immediately below each nadir of intersection to prevent erosion of the base of the tooth below the intersections of the inserts.

Abstract: Compounds, conjugates and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds may be useful, among other things, in treating of cancer and inhibiting ALKS. Compounds incorporated into a conjugate with an antibody construct are also described herein.

Abstract: Various compositions are disclosed for the treatment of viral infections. The compositions of conjugates comprise antibody constructs attached to myeloid cell agonists via a linker are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating viral infections, such as viral liver diseases.

Abstract: ALK5 inhibitor compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of cancer and fibrosis and modulating ALK5. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein.

Abstract: The present disclosure relates to fuse multiple database tables together. The fields of the database tables may be normalized using semantic fields. Under a first approach, database tables are deduplicated by consolidating redundant records. This may be done by performing pairwise comparisons to identify related pairs of records and then clustering the related pairs of records. Then, the deduplicated database tables are merged by performing another pairwise comparison. Under a second approach, the database tables may be concatenated. Thereafter, records are subject to pairwise comparisons and then clustered to create a merged database table.

Abstract: Aqueous formulations comprising conjugates that comprise a compound comprising benzazepine or a benzazepine-like structure conjugated to a polypeptide are provided, as well as methods of treatment using the aqueous formulations. Lyophilized compositions comprising the conjugates that comprise a compound comprising benzazepine or a benzazepine-like structure conjugated to a polypeptide are also provided.

Abstract: An end connector for a jacketed cable includes a rear body having a cylindrical retention portion with an outer surface that includes a plurality of recessed annular grooves. The cylindrical crimp comprises a plurality of thicker annular regions adjacent to and separated by a plurality of thinner annular regions. Each thicker annular region of the cylindrical crimp is axially aligned with a corresponding recessed annular groove on the outer surface of the cylindrical retention portion of the rear body, and such alignment is maintained during crimping to trap strength members of the jacketed cable.

Abstract: A sampling system is provided. The sampling system includes a housing. Mounted to the housing is a Hall effect sensor. A probe configured to contact a sample is inserted into the housing. The probe includes an elongated portion and a restorative spring inserted onto the elongated portion of the probe. The restorative spring provides sufficient restorative force to return the probe to a relaxed position. The Hall effect sensor is configured to sense a field strength generated by the proximity of the restorative spring of the probe in the extended position.

Abstract: The present disclosure relates to fuse multiple database tables together. The fields of the database tables may be normalized using semantic fields. Under a first approach, database tables are deduplicated by consolidating redundant records. This may be done by performing pairwise comparisons to identify related pairs of records and then clustering the related pairs of records. Then, the deduplicated database tables are merged by performing another pairwise comparison. Under a second approach, the database tables may be concatenated. Thereafter, records are subject to pairwise comparisons and then clustered to create a merged database table.