Abstract: Glioblastomas (GBMs) are primary brain lesions with poor overall survival rates. Nearly 95% of patients die within 5 years of primary diagnosis. One of the leading factors to this high mortality is the inevitable nature of cancer recurrence. Disclosed herein are methods and compositions related to the identification and treatment of glioblastoma. Specifically, disclosed herein are methods for identifying progressing glioblastoma, and distinguishing it from pseudo-progression.

Abstract: In some embodiments, a package for a computer peripheral device comprises an outer shell defining a first interior cavity and an open end. The package also comprises a peripheral tray comprising a rear side, a bottom side coupled to a bottom edge of the rear side, and a tongue. A first end of the tongue is coupled to the bottom side. The peripheral tray is positioned within the first interior cavity with a second end of the tongue coupled to the outer shell. An elongated portion of the tongue between the first end and the second end contacts the outer shell and is deflected toward the rear side. The peripheral tray is slidably translatable out of the first interior cavity through the open end so that a portion of the elongated portion moves away from the rear side and the bottom side rotates within the first interior cavity.

Abstract: A spinal implant for implantation within a spinal facet joint is provided. The spinal implant may include a main body including opposing top and bottom surfaces, opposing front or distal and rear or proximal surfaces, and opposing side surfaces. At least one retaining feature may be associated with at least one surface of the main body to frictionally engage the implant within the spinal facet joint. At least one securement feature may be associated with at least one surface of the main body to selectively secure the implant within the spinal facet joint.

Abstract: A spinal implant for implantation within a spinal facet joint is provided. The spinal implant may include a main body including opposing top and bottom surfaces, opposing front or distal and rear or proximal surfaces, and opposing side surfaces. At least one retaining feature may be associated with at least one surface of the main body to frictionally engage the implant within the spinal facet joint. At least one securement feature may be associated with at least one surface of the main body to selectively secure the implant within the spinal facet joint.