Patents by Inventor Wessel Matthijs Blankesteijn

Wessel Matthijs Blankesteijn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTAGONISTIC PEPTIDES FOR FRIZZLED-1 AND FRIZZLED-2
    Publication number: 20150071856
    Abstract: The invention is in the field of molecular medicine. It provides antagonistic compounds for frizzled-1 and/or frizzled-2 receptors, which may be useful in molecular imaging of the wound healing process after myocardial infarction and in therapeutic intervention into wound healing after remodeling of the heart, thereby ameliorating the consequences of myocardial infarction. The invention provides a method for antagonizing frizzled-1 or frizzled-2 receptors, wherein the receptor is contacted with a composition comprising a linear fragment of Wnt3(a) or Wnt5a or a functional analogue thereof, which comprises at least one cysteine residue, one threonine residue, one aspartic acid residue and one glycine residue.
    Type: Application
    Filed: September 12, 2013
    Publication date: March 12, 2015
    Inventors: Wessel Matthijs Blankesteijn, Hilde Laeremans, Tilman Mathias Hackeng
  • Antagonistic peptides for frizzled-1 and frizzled-2
    Patent number: 8598122
    Abstract: The invention is in the field of molecular medicine. It provides antagonistic compounds for frizzled 1 and/or frizzled-2 receptors, which may be useful in molecular imaging of the wound healing process after myocardial infarction and in therapeutic intervention into wound healing after remodeling of the heart, thereby ameliorating the consequences of myocardial infarction. The invention provides a method for antagonizing frizzled-1 or frizzled-2 receptors, wherein the receptor is contacted with a composition comprising a linear fragment of Wnt3(a) or Wnt5a or a functional analogue thereof, which comprises at least one cysteine residue, one threonine residue, one aspartic acid residue and one glycine residue.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: December 3, 2013
    Assignees: Universiteit Maastricht, Academisch Ziekenhuis Maastricht
    Inventors: Wessel Matthijs Blankesteijn, Hilde Laeremans, Tilman Mathias Hackeng
  • ANTAGONISTIC PEPTIDES FOR FRIZZLED-1 AND FRIZZLED-2
    Publication number: 20120014876
    Abstract: The invention is in the field of molecular medicine. It provides antagonistic compounds for frizzled 1 and/or frizzled 2 receptors, which may be useful in molecular imaging of the wound healing process after myocardial infarction and in therapeutic intervention into wound healing after remodeling of the heart, thereby ameliorating the consequences of myocardial infarction. The invention provides a method for antagonizing frizzled-1 or frizzled-2 receptors, wherein the receptor is contacted with a composition comprising a linear fragment of Wnt3(a) or Wnt5a or a functional analogue thereof, which comprises at least one cysteine residue, one threonine residue, one aspartic acid residue and one glycine residue.
    Type: Application
    Filed: February 18, 2010
    Publication date: January 19, 2012
    Applicants: ACADEMISCH ZIEKENHUIS MAASTRICHT, UNIVERSITEIT MAASTRICHT
    Inventors: Wessel Matthijs Blankesteijn, Hilde Laeremans, Tilman Mathias Hackeng