Abstract: A pipette tip (10) including: a proximal end (11) and a proximal body region (12) defining a first cavity that receives a flatted pipette member; and a distal end (13) and a distal body region (14) defining a second cavity that receives and discharges a liquid aspirated by the pipette member; the cavities are in gas-liquid communication, the first cavity is defined by various resilient surfaces as defined herein, one cylindrical surface (25) forms a gas-liquid seal with the pipette member, and which surfaces are free of, for example, an internal stop structure, a distinct sealing structure, or both. Methods of making and using the article are also disclosed.