Patents by Inventor Westbrook Weaver
Westbrook Weaver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11931480Abstract: A hydrogel material for modulating an immune response in a human subject or other mammal includes a collection of microgel particles having one or more network cross linker components, wherein the microgel particles, when exposed to an endogenous or exogenous annealing agent, links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having interstitial spaces formed between the microgel particles and wherein the collection of microgel particles further includes at least one of an antigen and an adjuvant.Type: GrantFiled: February 14, 2017Date of Patent: March 19, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Westbrook Weaver, Tatiana Segura, Philip Scumpia, Donald R. Griffin
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Patent number: 11931481Abstract: A hydrogel material for use in a human subject or other mammal includes a collection of microgel particles having one or more network cross linker components, wherein the microgel particles, when exposed to an endogenous or exogenous annealing agent, links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having pores formed between the microgel particles wherein the pores are substantially devoid of hydrogel.Type: GrantFiled: July 30, 2022Date of Patent: March 19, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Westbrook Weaver, Tatiana Segura, Jaekyung Koh, Philip Scumpia, Donald R. Griffin
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Publication number: 20230190995Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.Type: ApplicationFiled: September 24, 2022Publication date: June 22, 2023Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
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Publication number: 20220370686Abstract: A hydrogel material for use in a human subject or other mammal includes a collection of microgel particles having one or more network cross linker components, wherein the microgel particles, when exposed to an endogenous or exogenous annealing agent, links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having pores formed between the microgel particles wherein the pores are substantially devoid of hydrogel.Type: ApplicationFiled: July 30, 2022Publication date: November 24, 2022Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Westbrook Weaver, Tatiana Segura, Jaekyung Koh, Philip Scumpia, Donald R. Griffin
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Patent number: 11464886Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.Type: GrantFiled: January 8, 2021Date of Patent: October 11, 2022Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
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Publication number: 20210138105Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.Type: ApplicationFiled: January 8, 2021Publication date: May 13, 2021Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
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Patent number: 10912860Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.Type: GrantFiled: September 11, 2017Date of Patent: February 9, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
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Publication number: 20200305773Abstract: A biocompatible analyte sensing material for intradermal or subcutaneous application includes a collection of microgel particles having one or more network crosslinker components and an endogenous or exogenous annealing agent that links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. A plurality of analyte-specific fluorophores are conjugated to the microgel particles, wherein the analyte-specific fluorophores, in the presence of the analyte and subject to excitation radiation, emit fluorescent light. The analyte sensing material may, in some embodiments, be applied to an excision made in the skin or injected into the skin of a subject.Type: ApplicationFiled: January 20, 2017Publication date: October 1, 2020Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Westbrook Weaver, Donald Griffin, Jaekyung Koh
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Publication number: 20200306413Abstract: A hydrogel material for modulating an immune response in a human subject or other mammal includes a collection of microgel particles having one or more network cross linker components, wherein the microgel particles, when exposed to an endogenous or exogenous annealing agent, links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having interstitial spaces formed between the microgel particles and wherein the collection of microgel particles further includes at least one of an antigen and an adjuvant.Type: ApplicationFiled: February 14, 2017Publication date: October 1, 2020Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Westbrook Weaver, Tatiana Segura, Jaekyung Koh, Philip Scumpia, Donald R. Griffin
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Publication number: 20200237964Abstract: Disclosed herein are methods of manufacturing injectable microgel scaffolds, including methods of producing, purifying and concentrating microgel particles therein. The microgel scaffolds of the present disclosure are useful for a wide range of applications, such as stabilizing an implanted medical device in an implant site in a subject. The microgel scaffolds are fluidic during application and annealed or crosslinked after application to the implant site in the subject. The microgel scaffolds may contain various therapeutic agents, including antibiotics and analgesics, throughout the gel.Type: ApplicationFiled: April 6, 2020Publication date: July 30, 2020Inventors: Westbrook WEAVER, Stephanie DESHAYES, Samuel TIMKO
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Publication number: 20200222593Abstract: Disclosed herein are systems for promoting healing of a wound or surgical incision at a medical device site (e.g., implanted medical device) in a subject, by administering a microporous gel to the medical implant site. Also disclosed are systems for the treatment and prevention of infection at a medical implant site in a subject, by administering a microporous gel to the medical implant site. The microporous gel may be fluidic during application and annealed or crosslinked after application. The microporous gels may contain various therapeutic agents, including antibiotics and analgesics, throughout the gel.Type: ApplicationFiled: January 15, 2020Publication date: July 16, 2020Inventors: Westbrook WEAVER, Stephanie DESHAYES, Samuel TIMKO
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Patent number: 10668185Abstract: Disclosed herein are methods of manufacturing injectable microgel scaffolds, including methods of producing, purifying and concentrating microgel particles therein. The microgel scaffolds of the present disclosure are useful for a wide range of applications, such as stabilizing an implanted medical device in an implant site in a subject. The microgel scaffolds are fluidic during application and annealed or crosslinked after application to the implant site in the subject. The microgel scaffolds may contain various therapeutic agents, including antibiotics and analgesics, throughout the gel.Type: GrantFiled: June 28, 2019Date of Patent: June 2, 2020Assignee: TEMPO THERAPEUTICS, INC.Inventors: Westbrook Weaver, Stephanie Deshayes, Samuel Timko
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Publication number: 20200085859Abstract: Disclosed herein are therapeutic polymer gel systems for promoting healing of a wound or surgical site in a subject. The therapeutic polymer gel forms a microporous network and may be applied or injected in a fluid form and annealed or crosslinked after application to the wound or surgical site. The microporous gel may optionally contain various therapeutic agents throughout the therapeutic polymer gel which are released.Type: ApplicationFiled: October 8, 2019Publication date: March 19, 2020Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
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Patent number: 10576185Abstract: Disclosed herein are systems for promoting healing of a wound or surgical incision at a medical device site (e.g., implanted medical device) in a subject, by administering a microporous gel to the medical implant site. Also disclosed are systems for the treatment and prevention of infection at a medical implant site in a subject, by administering a microporous gel to the medical implant site. The microporous gel may be fluidic during application and annealed or crosslinked after application. The microporous gels may contain various therapeutic agents, including antibiotics and analgesics, throughout the gel.Type: GrantFiled: June 28, 2019Date of Patent: March 3, 2020Assignee: Tempo Therapeutics, Inc.Inventors: Westbrook Weaver, Stephanie Deshayes, Samuel Timko
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Publication number: 20190321520Abstract: Disclosed herein are systems for promoting healing of a wound or surgical incision at a medical device site (e.g., implanted medical device) in a subject, by administering a microporous gel to the medical implant site. Also disclosed are systems for the treatment and prevention of infection at a medical implant site in a subject, by administering a microporous gel to the medical implant site. The microporous gel may be fluidic during application and annealed or crosslinked after application. The microporous gels may contain various therapeutic agents, including antibiotics and analgesics, throughout the gel.Type: ApplicationFiled: June 28, 2019Publication date: October 24, 2019Inventors: Westbrook WEAVER, Stephanie DESHAYES, Samuel TIMKO
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Publication number: 20190321519Abstract: Provided are methods for the treatment and prevention of fibrosis at a medical implant site in a subject, by administering a microporous gel to the medical implant site. Also provided are methods of preventing or treating an infection at the medical implant site in a subject. Also disclosed herein are methods for promoting healing of a wound or surgical incision at a medical implant site in a subject, by administering a microporous gel to the medical implant site. The microporous gel may be fluidic during application and annealed or crosslinked after application. The microporous gels may contain various therapeutic agents, including antibiotics and analgesics, throughout the gel.Type: ApplicationFiled: June 28, 2019Publication date: October 24, 2019Inventors: Westbrook WEAVER, Stephanie DESHAYES, Samuel TIMKO
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Publication number: 20190321797Abstract: Disclosed herein are methods of manufacturing injectable microgel scaffolds, including methods of producing, purifying and concentrating microgel particles therein. The microgel scaffolds of the present disclosure are useful for a wide range of applications, such as stabilizing an implanted medical device in an implant site in a subject. The microgel scaffolds are fluidic during application and annealed or crosslinked after application to the implant site in the subject. The microgel scaffolds may contain various therapeutic agents, including antibiotics and analgesics, throughout the gel.Type: ApplicationFiled: June 28, 2019Publication date: October 24, 2019Inventors: Westbrook WEAVER, Stephanie DESHAYES, Samuel TIMKO
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Publication number: 20190151497Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.Type: ApplicationFiled: January 31, 2019Publication date: May 23, 2019Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
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Publication number: 20180078671Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.Type: ApplicationFiled: December 1, 2017Publication date: March 22, 2018Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia
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Publication number: 20170368224Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.Type: ApplicationFiled: September 11, 2017Publication date: December 28, 2017Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Donald R. Griffin, Westbrook Weaver, Tatiana Segura, Dino Di Carlo, Philip Scumpia