Abstract: Provided are techniques that may include a disposable magnetic cell isolation holder having one or more passages that accommodate a magnetic retention material to facilitate magnetic cell isolation without adjustment of magnetic field parameters between isolation procedures using different magnetic particle sizes. When the magnetic cell isolation holder is coupled to a magnetic field generator, a first passage corresponding to a smaller particle size is positioned in a magnetic field where the magnetic field characteristics are different relative to a second passage, of a second holder or in the same holder, for use with another bead size.

Abstract: Provided are techniques that may include a disposable magnetic cell isolation holder having one or more passages that accommodate a magnetic retention material to facilitate magnetic cell isolation without adjustment of magnetic field parameters between isolation procedures using different magnetic particle sizes. When the magnetic cell isolation holder is coupled to a magnetic field generator, a first passage corresponding to a smaller particle size is positioned in a magnetic field where the magnetic field characteristics are different relative to a second passage, of a second holder or in the same holder, for use with another bead size.

Abstract: Provided are techniques that may include a disposable magnetic cell isolation holder having one or more passages that accommodate a magnetic retention material to facilitate magnetic cell isolation without adjustment of magnetic field parameters between isolation procedures using different magnetic particle sizes. When the magnetic cell isolation holder is coupled to a magnetic field generator, a first passage corresponding to a smaller particle size is positioned in a magnetic field where the magnetic field characteristics are different relative to a second passage, of a second holder or in the same holder, for use with another bead size.

Abstract: Provided are techniques that may include a disposable magnetic cell isolation holder having one or more passages that accommodate a magnetic retention material to facilitate magnetic cell isolation without adjustment of magnetic field parameters between isolation procedures using different magnetic particle sizes. When the magnetic cell isolation holder is coupled to a magnetic field generator, a first passage corresponding to a smaller particle size is positioned in a magnetic field where the magnetic field characteristics are different relative to a second passage, of a second holder or in the same holder, for use with another bead size.

Abstract: A rotating transducer assembly and method for use in volumetric ultrasound imaging and catheter-guided procedures are provided. The rotating transducer assembly comprises a transducer array mounted on a drive shaft and the transducer array is rotatable with the drive shaft, a motion controller coupled to the transducer array and the drive shaft for rotating the transducer, and at least one interconnect assembly coupled to the transducer for transmitting signals between the transducer and an imaging device, wherein the interconnection assembly is configured to reduce its respective torque load on the transducer and motion controller due to a rotating motion of the transducer.

Abstract: A catheter tip (50, 170) is provided that is adapted for mating attachment to a catheter body (90, 300). In an embodiment, the catheter tip (50,170) comprises a transducer array (32, 60, 110, 210) in electrical communication with an interconnect (120, 220) and in a mechanical driven relationship with an actuator (80), also in the catheter tip (50, 170), via a drive shaft (38, 82). Oscillating back and forth motion of the transducer array (32, 60, 110, 210) provides ultrasonic imaging functionality that may include real time three-dimensional imaging. Other embodiments of the catheter tip (50, 170) and methods of fabrication also are provided.

Abstract: A catheter tip (50, 170, 750) is provided that is adapted for mating attachment to a catheter body (90, 300, 790). In an embodiment, the catheter tip (50, 170, 750) comprises a transducer array (32, 60, 110, 210, 710) in electrical communication with an interconnect (120, 220, 720) and in a mechanical driven relationship with an actuator (80, 730), also in the catheter tip (50, 170, 750), via a drive shaft (38, 82, 732). The transducer array (710) is encapsulated in a potting material body 711 providing a desired ultrasound acoustical transmission, A defined annular space 761 exists between an outer capsule 752 of the catheter tip 750 and the potting material body 711. Oscillating back and forth motion of the transducer array (32, 60, 110, 210, 710) provides ultrasonic imaging functionality that may include real time three-dimensional imaging. Other embodiments of the catheter tip (50, 170, 750) and methods of fabrication also are provided.

Abstract: A method to fabricate a catheter tip that encapsulates a mechanically actuated ultrasound transducer assembly is provided.

Abstract: Alternative embodiments are provided, for use individually or in combination, for thermal management of catheter distal ends and other types of probes such as may be used in catheter and other instruments' diagnostic and interventional devices. In an exemplary embodiment, a catheter distal end (1000) comprises an ultrasound imaging assembly (1003) that comprises an actuator (1004), a drive shaft (1006), a section (1008) of an interconnect (1010), and a transducer assembly (1009). A circulation fin (1018) optionally may be affixed to the bottom (1016) of transducer assembly (1009), and extends into a defined space (1017) to enhance circulation of acoustic transmission medium that is in the defined space (1017). This disperses heat from the actuator (1004) and the transducer assembly (1009). A similar fin (1018) may also, or alternatively, be positioned on the section (1008) of interconnect (1010). Other thermal management approaches also are disclosed.

Abstract: A mobile radiographic device for use in inspecting pipelines and the like, comprising an articulating aerial boom coupled to a mobile carriage vehicle. A pivot mount is rotatably coupled to the distal end of the aerial boom. A platform having a sliding rail is operatively coupled to the pivot mount. A mounting fixture is rotatably mounted to a cradle, which in turn is coupled to the sliding rail of the platform. A radiation source and a radiation detector are mounted on diametrically opposing sides of the fixture in order to illuminate the outer surface of a pipeline or other object with radiation. A first positioning means is provided for coarsely positioning the scanning apparatus relative to the pipeline. A second positioning means is provided for finely positioning the scanning apparatus relative to the pipeline. The second positioning means is operable from a remote location when the radiation source is illuminating the pipeline with radiation.