Abstract: The present invention relates to a composition for predicting resistance to chemotherapy for ovarian cancer and uses thereof, and more particularly, as the expression of exosome-derived miR-214-3p in epithelial ovarian cancer patients increases, the expression of the target gene LHX6 is suppressed, malignancy of epithelial ovarian cancer and anticancer drug resistance are increased, the change in the expression level of miR-214-3p and LHX6 can be provided as a composition for predicting the prognosis of cancer malignancy and anticancer drug resistance in epithelial ovarian cancer patients, and as it was confirmed that apoptosis of epithelial ovarian cancer cells treated with miR-214-3p inhibitors increases and the anticancer drug resistance is regulated by the expression regulation of miR-214-3p and LHX6, the miR-214-3p inhibitor and the activator or expression promoter of LHX6 may be provided as an anti-cancer therapeutic agent or an anti-cancer drug sensitizer for epithelial ovarian cancer cells.