Patents by Inventor Wheeseong Lee

Wheeseong Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dihydropyridine derivatives as useful as protein kinase inhibitors
    Patent number: 8198456
    Abstract: This invention provides novel dihydropyridine derivatives of the formula I having protein tyrosine kinase inhibitory activity, to process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: June 12, 2012
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Marc Adler, Stefan Baeurle, Judi Bryant, Ming Chen, Yuo-Ling Chou, Paul Hrvatin, Seock-Kyu Khim, Monica Kochanny, Wheeseong Lee, Michael Mamounas, Janet Meurer Ogden, Gary Bruce Phillips, Victor Selchau, Christopher West, Bin Ye, Shendong Yuan, Martin Krueger
  • 5-cyano-prostacyclin derivatives as agents for the treatment of influenza a viral infection
    Patent number: 7776896
    Abstract: This invention is directed to compounds of formula (I): where A, B, D, E, m, and R1-R5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating respiratory diseases associated with influenza A viruses, such as for example H5N1 and its mutations. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: August 17, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: William Guilford, Werner Skuballa, Daryl H. Faulds, Monica Kochanny, Wheeseong Lee, Bernd Radüchel
  • Novel 5-cyano-prostacyclin derivatives as agents for the treatment of autoimmune diseases
    Publication number: 20080242713
    Abstract: This invention is directed to compounds of formula (I): where A, B, D, E, m, and R1-R5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating autoimmune diseases. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
    Type: Application
    Filed: March 27, 2008
    Publication date: October 2, 2008
    Inventors: William Guilford, Werner Skuballa, Daryl H. Faulds, Monica Kochanny, Wheeseong Lee, Bernd Raduchel
  • Novel 5-cyano-prostacyclin derivatives as agents for the treatment of influenza a viral infection
    Publication number: 20080242714
    Abstract: This invention is directed to compounds of formula (I): where A, B, D, E, m, and R1-R5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating respiratory diseases associated with influenza A viruses, such as for example H5N1 and its mutations. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
    Type: Application
    Filed: March 27, 2008
    Publication date: October 2, 2008
    Applicant: Bayer Schering Pharma Aktiengesellschaft
    Inventors: William Guilford, Werner Skuballa, Daryl H. Faulds, Monica Kochanny, Wheeseong Lee, Bernd Raduchel
  • DIHYDROPYRIDINE DERIVATIVES AS USEFUL AS PROTEIN KINASE INHIBITORS
    Publication number: 20080176833
    Abstract: This invention provides novel dihydropyridine derivatives of the formula I having protein tyrosine kinase inhibitory activity, to process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions.
    Type: Application
    Filed: December 13, 2007
    Publication date: July 24, 2008
    Inventors: Marc Adler, Stefan Baeurle, Judi Bryant, Ming Chen, Yuo-Ling Chou, Paul Hrvatin, Seock-Kyu Khim, Monica Kochanny, Wheeseong Lee, Michael Mamounas, Janet Meurer Ogden, Gary Bruce Phillips, Victor Selchau, Christopher West, Bin Ye, Shendong Yuan, Martin Krueger
  • Tetrahydronaphthalene derivatives, processes for their preparation and their use as antiinflammatory agents
    Publication number: 20070129359
    Abstract: The invention relates to multiply substituted tetrahydronaphthalene derivatives of the formula (I) processes for their preparation and their use as anti-inflammatory agents.
    Type: Application
    Filed: May 1, 2006
    Publication date: June 7, 2007
    Inventors: Christoph Huwe, Werner Skuballa, Duy Nguyen, Heike Schaecke, Wheeseong Lee
  • Substituted quinoline CCR5 receptor antagonists
    Patent number: 7220856
    Abstract: The present invention relates to CCR5 receptor antagonists of formulae (1a) or (1b): enantiomers, diastereomers, salts and solvates thereof wherein R1, R2, R3, R4, R5, and R7 are as defined herein. The invention further includes a method of CCR5-mediated disorders employing such compounds.
    Type: Grant
    Filed: June 26, 2003
    Date of Patent: May 22, 2007
    Assignee: Schering Aktiengesellschaft
    Inventors: Laura Dunning, Stefan Jaroch, Monica J. Kochanny, Wheeseong Lee, Xiongdong Lian, Meina Liang, Shou-Fu Lu, James Onuffer, Gary Phillips, Guo-Ping Wei, Bin Ye
  • Indolinone derivatives and their use in treating disease-states such as cancer
    Patent number: 7105563
    Abstract: Indolinone derivatives, such as compounds of the formula (I): wherein A, m, n, R1, R2, R3, R5 and R6 are described herein, are disclosed herein as being useful in treating mammal having disease-states alleviated by the inhibition of PDK-1 activity.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: September 12, 2006
    Assignee: Schering Aktiengesellschaft
    Inventors: Damian Arnaiz, Judi Bryant, Yuo-Ling Chou, Richard Feldman, Paul Hrvatin, Imadul Islam, Monica Kochanny, Wheeseong Lee, Mark Polokoff, Hongyi Yu, Shendong Yuan
  • Piperidine derivatives and their use as anti-inflammatory agents
    Publication number: 20060167044
    Abstract: Piperidine derivatives of the following formulae I and II: and their pharmaceutically acceptable salts, which are functional antagonists of the CC chemokine receptor CCR1 and are thus useful as anti-inflammatory agents, a pharmaceutical compositions containing said piperidine derivatives or their pharmaceutically acceptable salts, and methods of their use.
    Type: Application
    Filed: December 19, 2005
    Publication date: July 27, 2006
    Inventors: Damian Arnaiz, Yuo-Ling Chou, Monica Kochanny, Wheeseong Lee, Shou-Fu Lu, Anne Mengel, Gary Phillips, Guo Wei, Hongyi Yu
  • Benzylether amine compounds useful as CCR-5 antagonists
    Publication number: 20050101644
    Abstract: The present invention relates to compounds which are CCR-5 receptor antagonists of the general formula I: wherein R1, R2, R3, R4, Ra, Rb, Rc, Rd, X, m and n are as defined herein. The invention further comprises pharmaeceutical compositions comprising such compounds, as well as the use of such compounds to treat CCR-5 mediated disorders.
    Type: Application
    Filed: November 8, 2004
    Publication date: May 12, 2005
    Applicant: Schering Aktiengesellschaft
    Inventors: David Davey, Wheeseong Lee, Shou-Fu Lu, Gary Phillips, Guo Ping Wei, Bin Ye
  • Indolinone derivatives and their use in treating disease-states such as cancer
    Publication number: 20050090541
    Abstract: Indolinone derivatives, such as compounds of the formula (I): wherein A, m, n, R1, R2, R3, R5 and R6 are described herein, are disclosed herein as being useful in treating mammal having disease-states alleviated by the inhibition of PDK-1 activity.
    Type: Application
    Filed: October 22, 2004
    Publication date: April 28, 2005
    Applicant: Schering Aktiengesellschaft
    Inventors: Damian Arnaiz, Judi Bryant, Yuo-Ling Chou, Richard Feldman, Paul Hrvatin, Imadul Islam, Monica Kochanny, Wheeseong Lee, Mark Polokoff, Hongyi Yu, Shendong Yuan
  • Substituted quinoline CCR5 receptor antagonists
    Publication number: 20040072818
    Abstract: The present invention relates to CCR5 receptor antagonists of formulae (1a) or (1b): 1
    Type: Application
    Filed: June 26, 2003
    Publication date: April 15, 2004
    Applicant: Schering Aktiengesellschaft
    Inventors: Laura Dunning, Stefan Jaroch, Monica J. Kochanny, Wheeseong Lee, Xiongdong Lian, Meina Liang, Shou-Fu Lu, James Onuffer, Gary Phillips, Guo-Ping Wei, Bin Ye
  • Ortho-anthranilamide derivatives as anti-coagulants
    Patent number: 6498185
    Abstract: This invention is directed to compounds of formula (III): wherein B, C, D, E, R1, R2 and R3 are disclosed herein. These compounds are disclosed as being useful as anti coagulants.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: December 24, 2002
    Assignee: Berlex Laboratories, Inc.
    Inventors: Damian O. Arnaiz, Yuo-Ling Chou, Brian D. Griedel, Rushad E. Karanjawala, Monica J. Kochanny, Wheeseong Lee, Amy Mei Liang, Michael M. Morrissey, Gary B. Phillips, Karna Lyn Sacchi, Steven T. Sakata, Kenneth J. Shaw, R. Michael Snider, Shung C. Wu, Bin Ye, Zuchun Zhao
  • Ortho-anthranilamide derivatives as anti-coagulants
    Patent number: 6380221
    Abstract: This invention is directed to compounds of formula (III): wherein B, C, D, E, R1, R2 and R3 are disclosed herein. These components are disclosed as being useful as anti-coagulants.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: April 30, 2002
    Assignee: Berlex Laboratories, Inc.
    Inventors: Damian O. Arnaiz, Yuo-Ling Chou, Brian D. Griedel, Rushad E. Karanjawala, Monica J. Kochanny, Wheeseong Lee, Amy Mei Liang, Michael M. Morrissey, Gary B. Phillips, Karna Lyn Sacchi, Steven T. Sakata, Kenneth J. Shaw, R. Michael Snider, Shung C. Wu, Bin Ye, Zuchun Zhao
  • Ortho-anthranilamide derivatives as anti-coagulants
    Patent number: 6140351
    Abstract: This invention is directed to compounds of formula (III): ##STR1## wherein B, C, D, E, R.sup.1, R.sup.2 and R.sup.3 are disclosed herein. These compounds are disclosed as being useful as anti-coagulants.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: October 31, 2000
    Assignee: Berlex Laboratories, Inc.
    Inventors: Damian O. Arnaiz, Yuo-Ling Chou, Brian D. Griedel, Rushad E. Karanjawala, Monica J. Kochanny, Wheeseong Lee, Amy Mei Liang, Michael M. Morrissey, Gary B. Phillips, Karna Lyn Sacchi, Steven T. Sakata, Kenneth J. Shaw, R. Michael Snider, Shung C. Wu, Bin Ye, Zuchun Zhao