Abstract: A universal dental prosthesis retention system adapted to interconnect a dental implant secured in a patient's jaw bone to an artificial dental prosthesis. The retention system includes an implant insert having a first longitudinal axis and securable into the dental implant, a prosthesis insert having a second longitudinal axis and securable within the dental prosthesis, and a universal connector adapted to interconnect the implant insert and prosthesis insert. The universal connector is also adapted to facilitate preselected or adjustable universal angular alignment between the first and second axes, that angular relationship then securably lockable to enable the dental prosthesis to be thereafter securely mounted over the prosthesis insert. Various locking structures and universal connector structure are provided.