Patents by Inventor Wilford L. Mendelson

Wilford L. Mendelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediates for preparing epoxy esters
    Patent number: 5208353
    Abstract: This invention relates to a process for preparing epoxy esters, and intermediates prepared by this process, in particular, to a process which produces non-racemic epoxy esters which are of use as intermediates in the preparation of pharmaceutical compounds.
    Type: Grant
    Filed: July 15, 1992
    Date of Patent: May 4, 1993
    Assignee: SmithKline Beecham Corp.
    Inventors: Joseph R. Flisak, Paul G. Gassman, Ivan Lantos, Wilford L. Mendelson
  • Process for preparation of epoxy esters and intermediates prepared thereby
    Patent number: 5110959
    Abstract: This invention relates to a process for preparing epoxy esters, and intermediates prepared by this process, in particular, to a process which produces non-racemic epoxy esters which are of use as intermediates in the preparation of pharmaceutical compounds.
    Type: Grant
    Filed: June 14, 1989
    Date of Patent: May 5, 1992
    Assignee: Smithkline Beckman Corp.
    Inventors: Joseph R. Flisak, Paul G. Gassman, Ivan Lantos, Wilford L. Mendelson
  • Method for preparing tetrahydroisoquinolines
    Patent number: 4251660
    Abstract: A method for preparing 1,2,3,4-tetrahydroisoquinolines comprising heating N-halo or hydroxyethyl-N-benzylamines in an aluminum chloride melt at 160.degree.-210.degree..
    Type: Grant
    Filed: August 10, 1978
    Date of Patent: February 17, 1981
    Assignee: SmithKline Corporation
    Inventors: Bing L. Lam, Wilford L. Mendelson, Charles B. Spainhour, Jr.
  • 1,1,1-Trihalo-2-hydroxy-4-(2-hydroxyphenyl)-4-butanones
    Patent number: 4193941
    Abstract: A new synthesis for the preparation of 6-(2-hydrophenyl)-3-pyridazinones whose key reaction is cyclizing a 1,1,1-trihalo-2-hydroxy-4-(2-hydroxyphenyl)-4-butanone with hydrazine. 6-(2-Hydroxyphenyl)-3-pyridazinones are important intermediates for preparing medicinally active compounds especially 3-[2-(3-tert.-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine or its nontoxic acid addition salts. The invention claimed here is the trihalocarbinol intermediates.
    Type: Grant
    Filed: October 5, 1978
    Date of Patent: March 18, 1980
    Assignee: SmithKline Corporation
    Inventors: Sidney H. Levinson, Wilford L. Mendelson
  • 3-(o-Hydroxyphenyl)-5-formylhydrazino-.DELTA..sup.2 -pyrazolines
    Patent number: 4189578
    Abstract: New 3-(o-hydroxyphenyl)-5-formylhydrazino-.DELTA..sup.2 -pyrazolines useful in the preparation of 6-(2-hydrophenyl)-3-pyridazinones which are in turn important intermediates for preparing medicinally active compounds especially 3-[2-(3-tert.-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine.
    Type: Grant
    Filed: March 1, 1979
    Date of Patent: February 19, 1980
    Assignee: SmithKline Corporation
    Inventors: Sidney H. Levinson, Wilford L. Mendelson
  • Synthesis of 6-(2-hydroxyphenyl)-3(2H)-pyridazinones from trihalocarbinols
    Patent number: 4152517
    Abstract: A new synthesis for the preparation of 6-(2-hydroxyphenyl)-3-pyridazinones whose key reaction is cyclizing a 1,1,1-trihalo-2-hydroxy-4-(2-hydroxyphenyl)-1-butanone with hydrazine. 6-(2-Hydroxyphenyl)-3-pyridazinones are important intermediates for preparing medicinally active compounds.
    Type: Grant
    Filed: October 19, 1977
    Date of Patent: May 1, 1979
    Assignee: SmithKline Corporation
    Inventors: Sidney H. Levinson, Wilford L. Mendelson
  • Process for preparing 4-(hydroxymethyl)imidazole compounds
    Patent number: 4063023
    Abstract: An improved process for the preparation of 4-(hydroxymethyl)imidazoles by reducing 4-imidazolecarboxylic acid esters using an alkali metal or calcium in liquid ammonia with an additional proton source provided during the reaction or upon workup.
    Type: Grant
    Filed: May 27, 1976
    Date of Patent: December 13, 1977
    Assignee: SK&F Lab Co.
    Inventors: Elvin L. Anderson, Wilford L. Mendelson, George R. Wellman