Patents by Inventor Wilfred NGWA

Wilfred NGWA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biomaterials for combined radiotherapy and immunotherapy of cancer
    Patent number: 10835604
    Abstract: Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually. The implant may be configured as, or be a component of, brachytherapy spacers and applicators, or radiotherapy fiducial markers. The composition may be combined with marginless radiotherapy, allowing for lower doses of radiation and enhancing the immune response against cancer, including at non-irradiated sites.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: November 17, 2020
    Assignees: Northeastern University, Dana-Farber Cancer Institute, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Wilfred Ngwa, Rajiv Kumar, Gerassimos Makrigiorgos, Srinivas Sridhar, Stephanie Dougan
  • Biopolymer-nanoparticle composite implant for tumor cell tracking
    Patent number: 10799604
    Abstract: A method of detecting migration of tumor cells is provided by implanting in a region of tumor cells one or more implants having a matrix material of a biocompatible and biodegradable polymer, and a plurality of nanoparticles dispersed within the matrix material and functionalized to bind tumor cells. Nanoparticles bound to the tumor cells that have migrated out of the region can be detected by various imaging modalities. The implant can be in the shape of a brachytherapy spacer or radiotherapy fiducial maker or can be a coating on a brachytherapy spacer or fiducial marker. A method of treating cancer is provided by implanting one or more brachytherapy spacers or fiducial markers including the matrix material and an anti-cancer therapeutic agent dispersed within the matrix material.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: October 13, 2020
    Assignees: Northeastern University, Dana-Farber Cancer Institute, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Rajiv Kumar, Srinivas Sridhar, Wilfred Ngwa, Robert Cormack, Gerassimos Makrigiorgos
  • BIOMATERIALS FOR COMBINED RADIOTHERAPY AND IMMUNOTHERAPY OF CANCER
    Publication number: 20180271978
    Abstract: Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually. The implant may be configured as, or be a component of, brachytherapy spacers and applicators, or radiotherapy fiducial markers. The composition may be combined with marginless radiotherapy, allowing for lower doses of radiation and enhancing the immune response against cancer, including at non-irradiated sites.
    Type: Application
    Filed: August 15, 2016
    Publication date: September 27, 2018
    Applicants: Northeastern University, Dana-Farber Cancer Institute, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Wilfred Ngwa, Rajiv Kumar, Gerassimos Makrigiorgos, Srinivas Sridhar, Stephanie Dougan
  • Biopolymer-Nanoparticle Composite Implant for Tumor Cell Tracking
    Publication number: 20170209601
    Abstract: A method of detecting migration of tumor cells is provided by implanting in a region of tumor cells one or more implants having a matrix material of a biocompatible and biodegradable polymer, and a plurality of nanoparticles dispersed within the matrix material and functionalized to bind tumor cells. Nanoparticles bound to the tumor cells that have migrated out of the region can be detected by various imaging modalities. The implant can be in the shape of a brachytherapy spacer or radiotherapy fiducial maker or can be a coating on a brachytherapy spacer or fiducial marker. A method of treating cancer is provided by implanting one or more brachytherapy spacers or fiducial markers including the matrix material and an anti-cancer therapeutic agent dispersed within the matrix material.
    Type: Application
    Filed: July 27, 2015
    Publication date: July 27, 2017
    Inventors: Rajiv KUMAR, Srinivas SRIDHAR, Wilfred NGWA, Robert CORMACK, Gerassimos MAKRIGIORGOS