Abstract: System and methods are described herein for detecting positions or trajectories and/or controlling directions of charged droplets during travel. The systems and methods are useful for determining the locations of the charged droplets in real-time based on signals induced in the electrodes of a sensor surrounding an aperture through which the charged droplet passes in flight from the source well to the target. The signals from the sensor electrodes can be measured and used to determine a position or trajectory of the droplet. The systems and methods are useful for modifying trajectories of the charged droplets in real-time, such as based on determined positions identified as having a trajectory deviating from the target. The trajectories can be modified by applying voltages to electrodes surrounding an aperture through which the charged droplet passes in flight from the source well to the target.