Abstract: A coupling assembly for coupling a rod to a bone anchoring element is provided, wherein the coupling assembly includes a receiving part having a first end, a second end, a central axis extending through the first end and second end, an accommodation space for accommodating a head of an anchoring element, a bore extending from the accommodation space to the first end, and a recess for receiving a rod. The accommodation space has an opening at the second end sized to permit insertion of a head of the bone anchoring element. The coupling assembly further includes a retainer element configured to be positioned at least partially in the accommodation space and being radially expandable and/or compressible to allow retaining a head inserted through the opening. The retainer element is held in position adjacent the opening by an engagement structure provided at or in the accommodation space.

Abstract: A transdermal delivery system (TDS) having: a carrier layer (cover layer) impermeable to the substances/active ingredients to be delivered, a membrane permeable to the substances/active ingredients to be delivered, a reservoir containing substances/active ingredients to be delivered, the reservoir being provided between the carrier layer and the membrane; and a removable film, wherein the carrier layer and the membrane comprise electrodes such that the electrode(s) of the membrane serve(s) as counterelectrode(s) to the electrode (the electrodes) of the carrier layer, is disclosed.

Abstract: This invention relates to a transdermal system containing fentanyl as the active ingredient and consisting of or comprising a substrate, a mixture of the following ingredients applied to the substrate: the active ingredient, an oil-based aloe vera extract, a resin, and an adhesive, as well as a layer laminated to the mixture applied to the substrate.

Abstract: The present invention refers to a flat self-adhering plaster having a multi-layer construction and reduced cold flow, characterized in that the layer of adhesive possesses a core of adhesive being a flowable adhesive and a ring of adhesive being an adhesive having reduced flowability which surrounds the core.

Abstract: A device for dispensing liquid from a bag has upper and lower casing halves and a closure holding together the casing halves. A pressure piston in the casing can press the bag against the lower casing half. This piston is operated by a rocking lever having an upper end bearing on the upper casing half and a lower end on which the piston is pivoted and a tension spring and flexible element connected between the casing halves and the upper end of the rocking lever and angularly biasing the lever for movement from a generally horizontal position with the piston raised and a tilted position with the piston lowered for applying such a force to the pressure piston that a pressure is generated in the bag that causes the discharge of a constant liquid volume per unit of time.

Abstract: The transdermal system includes a sex hormone-containing adhesive matrix, which contains inclusions of a sex hormone in a hydrophilic non-crosslinked polymer in dissolved or dispersed form. The inclusions have a concentration of 20 to 90 percent by weight of the sex hormone, which is more than 50 percent by weight amorphous. The hydrophilic non-crosslinked polymer can be polyvinylpyrrolidone, methylcellulose, ethylcellulose or hydroxyethylcellulose. The adhesive matrix can be a polyisobutylene, ethylene-vinyl-acetate copolymer or a polystyrene-butadiene block copolymer.

Abstract: This present invention concerns transdermal systems for the release of clonidine, characterized in that the clonidine is contained in an adhesive layer on the basis of a styrene block polymer, as well as its use in the treatment of hypertonia, migraines, anxieties, hyperkinetic behavioral disorders, alcohol or drug-related withdrawal symptoms, and menopausal symptoms.

Abstract: The invention relates to an “intelligent”, electronically controlled transdermal delivery system (TDS) having

Abstract: A transdermal delivery system (TDS) having: a carrier layer (cover layer) impermeable to the substances/active ingredients to be delivered; a membrane permeable to the substances/active ingredients to be delivered; a reservoir containing substances/active ingredients to be delivered, the reservoir being provided between the carrier layer and the membrane; and a removable film, wherein each of the carrier layer and the membrane comprise one or more electrodes such that the electrode(s) of the membrane serve(s) as counter electrode(s) to die electrode (the electrodes) of the carrier layer, is disclosed.

Abstract: A non-invasive and non-systemic method for administering a local anesthetic. The method comprises topical application of a local anesthetic in combination with an intradermal-penetration agent selected from the group consisting an aloe composition, a triglyceride, and a mixture thereof.

Abstract: The invention relates to a matrix-controlled transdermal therapeutic system comprising (i) an active-ingredient-impermeable cover layer, (ii) a self-adhesive matrix layer, or a plurality of matrix layers of which at least the matrix layer exposed while applying the system is self-adhesive, or one or more matrix layers whose surface remote from the cover layer and intended for adhesion at the application site is coated with an adhesive, the matrix layers comprising at least one ACE inhibitor (angiotensin converting enzyme inhibitor), the metabolite of which is a dicarboxylic acid and which is selected from the following group:

Abstract: The invention relates to a pharmaceutical preparation which consists of or contains cyclosporin A, an emulsifying &agr;-tocopherol derivative, an ethoxylation product of vegetable oils, fatty acids or fats as a further emulsifier and a pharmaceutically customary alcohol.

Abstract: The invention relates to transdermal systems for the delivery of clonidine, characterised in that the clonidine is located in a contact adhesive layer based on a 2-ethylhexyl acrylate/vinyl acetate copolymer, and to their use in the treatment of hypertension, migraine, anxiety states, hyperkinetic behavioural disorders, withdrawal symptoms in alcohol or drug withdrawal and menopausal symptoms.

Abstract: This invention relates to a transdermal system containing fentanyl as the active ingredient and consisting of or comprising

Abstract: The invention relates to a patch for transdermal application of pergolid and its pharmaceutically acceptable salts.

Abstract: A non-invasive and non-systemic method for administering a local anesthetic. The method comprises topical application of a local anesthetic in combination with an intradermal-penetration agent selected from the group consisting an aloe composition, a triglyceride, and a mixture thereof.

Abstract: A non-invasive and non-systemic method for administering a local anesthetic. The method comprises topical application of a local anesthetic in combination with an intradermal-penetration agent selected from the group consisting an aloe composition, a triglyceride, and a mixture thereof.

Abstract: This invention refers to a transdermal system for release of 5-HT3 receptor antagonists which is characterized in that it contains a composition of a 5-HT3 receptor antagonist as an active agent, tea tree oil, a water-miscible solvent and water.

Abstract: A transdermal patch contains an active loratidine metabolite contained with polyacrylate polymer matrix. The transdermal patch provides pharmaceutically useful transdermal flux rates over time.

Abstract: The invention relates to a transdermal system containing at least one angiotensin-converting enzyme inhibitor.