Patents by Inventor Wilhelm G. Frank

Wilhelm G. Frank has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9453010
    Abstract: The invention concerns compounds based on benzoxazoles wherein selected substituents are each a reactive group A bound via a linker L and adapted to covalently bond a compound of the invention to a to-be-marked molecule K, wherein A is an amine, hydroxy or phosphoramidite function, a carboxylic acid, an alkyl or active ester derived therefrom; a carboxylic acid hydrazide; or a carboxylic acid amide where K is a covalently bound component selected from the group haptenes, proteins (antibodies), low molecular weight drug compounds, peptides, nucleotides, nucleosides, DNA oligomers, polymers, and t is from 1 to 10, and L is a linker selected from a group featuring —(CH2)s—, —[(CH2)m—O]p—(CH2)m—, —NR10-(CH2)s—, —O—(CH2)s—, —S—(CH2)s—, —NR10-C(O)—(CH2)s—, —NR10-C(O)—O—(CH2)s—, —NR10-C(O)—NR11-(CH2)s— or —SO2—NR10-(CH2)s—, wherein R10 and R11 are each independently hydrogen, alkyl and alkoxy-alkyl (—[(CH2)m—O]p—CH3), ?-sulfoalkyl (—(CH2)r—SO3), m represents the numbers of 2-5, p, r and s each independently represen
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: September 27, 2016
    Assignee: DYOMICS GMBH
    Inventors: Bernd G. Schweder, Matthias S. Wenzel, Wilhelm G. Frank, Frank G. Lehmann, Peter T. Czerney
  • Publication number: 20150175591
    Abstract: The invention concerns compounds based on benzoxazoles wherein selected substituents are each a reactive group A bound via a linker L and adapted to covalently bond a compound of the invention to a to-be-marked molecule K, wherein A is an amine, hydroxy or phosphoramidite function, a carboxylic acid, an alkyl or active ester derived therefrom; a carboxylic acid hydrazide; or a carboxylic acid amide where K is a covalently bound component selected from the group haptenes?, proteins (antibodies), low molecular weight drug compounds, peptides, nucleotides, nucleosides, DNA oligomers, polymers, and t is from 1 to 10, and L is a linker selected from a group featuring —(CH2)s—, —[(CH2)m—O]p—(CH2)m—, —NR10-(CH2)s—, —O—(CH2)s—, —S—(CH2)s—, —NR10-C(O)—(CH2)s—, —NR10-C(O)—O—(CH2)s—, —NR10-C(O)—NR11-(CH2)s— or —SO2—NR10-(CH2)s—, wherein R10 and R11 are each independently hydrogen, alkyl and alkoxy-alkyl (—[(CH2)m—O]p—CH3), ?-sulfoalkyl (—(CH2)r—SO3), m represents the numbers of 2-5, p, r and s each independently repres
    Type: Application
    Filed: December 22, 2014
    Publication date: June 25, 2015
    Inventors: Bernd G. SCHWEDER, Matthias S. WENZEL, Wilhelm G. FRANK, Frank G. LEHMANN, Peter T. CZERNEY
  • Patent number: 8039648
    Abstract: Compounds used as dyes comparable to Alexa Fluor 350 dyes. The inventive compounds have high fluorescence quantum yield and high photostability. The dyes facilitate analysis of biological structures with enhanced sensitivity and selectivity.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: October 18, 2011
    Assignee: Pierce Biotechnology, Inc.
    Inventors: Peter T. Czerney, Surbhi Desai, Matthias S. Wenzel, Boguslawa Dworecki, Frank G. Lehmann, Bernd G. Schweder, Wilhelm G. Frank
  • Publication number: 20100317045
    Abstract: Compounds used as dyes comperable to Alexa Fluor 350 dyes. The inventive compounds have high fluorescence quantum yield and high photostability. The dyes facilitate analysis of biological structures with enhanced sensitivity and selectivity.
    Type: Application
    Filed: June 16, 2009
    Publication date: December 16, 2010
    Applicant: PIERCE BIOTECHNOLOGY, INC.
    Inventors: Surbhi Desai, Boguslawa Dworecki, Matthias S. Wenzel, Peter T. Czerney, Frank G. Lehmann, Bernd G. Schweder, Wilhelm G. Frank
  • Patent number: 7745640
    Abstract: Compounds, compositions, and methods for optical, including fluorescence optical, determinations useful in labelling biomolecules such as protein and deoxyribonucleic acid for their detection and quantitation. The compounds are diasteromeric cyanines with high hydrophilicity and other desirable properties.
    Type: Grant
    Filed: December 5, 2006
    Date of Patent: June 29, 2010
    Assignee: Dyomics GmbH
    Inventors: Peter T. Czerney, Wilhelm G. Frank, Frank G. Lehmann, Bernd G. Schweder, Matthias S. Wenzel
  • Patent number: 7745645
    Abstract: Compounds having the general of formula I and/or formula II wherein R1 and R2 are the same or different and are independently selected from the group consisting of —H, —C1-C18-alkyl or -?-sulfoalkyl; X and Y are the same or different and are independently selected from the group consisting of —O?, —OH, —SH, —NH—NH2, —F, —Cl, —Br, —I, —O-Su (succinimidyl/sulfosuccinimidyl), —O-STP (4-sulfo-2,3,5,6-tetrafluorophenyl), —O-TFP (2,3,5,6-tetrafluorophenyl), —O-benzotriazole, -benzotriazole, —NR—CO—CH2—I, —NR2, —NR-biomolecule, —NR-L-COO?, —NR-L-COOH, —NR-L-COO-Su, —NR-L-COO-STP, —NR-L-COO-TFP, —NR-L-CONR2, —NR-L-CO-biomolecule, —NR-L-CO—NH—NH2, —NR-L-OH, —NR-L-O-phosphoramidite, —NR-L-CHO, —NR-L-maleimid, or —NR-L-NH—CO—CH2—I; where R is equal to R1 and R2 and L is selected from the group consisting of a divalent linear (—(CH2)o—, o=1 to 15), crossed, or cyclic alkane group that can be substituted by at least one atom selected from the group consisting of oxygen, substituted ni
    Type: Grant
    Filed: January 22, 2007
    Date of Patent: June 29, 2010
    Assignee: Pierce Biotechnology, Inc.
    Inventors: Wilhelm G. Frank, Matthias S. Wenzel, Peter T. Czerney, Surbhi Desai, Greg Hermanson
  • Publication number: 20080177086
    Abstract: Compounds having the general of formula I and/or formula II wherein R1 and R2 are the same or different and are independently selected from the group consisting of —H, —C1-C18-alkyl or -?-sulfoalkyl; X and Y are the same or different and are independently selected from the group consisting of —O?, —OH, —SH, —NH—NH2, —F, —Cl, —Br, —I, —O-Su (succinimidyl/sulfosuccinimidyl), —O-STP (4-sulfo-2,3,5,6-tetrafluorophenyl), —O-TFP (2,3,5,6-tetrafluorophenyl), —O-benzotriazole, -benzotriazole, —NR—CO—CH2—I, —NR2, —NR-biomolecule, —NR-L-COO?, —NR-L-COOH, —NR-L-COO-Su, —NR-L-COO-STP, —NR-L-COO-TFP, —NR-L-CONR2, —NR-L-CO-biomolecule, —NR-L-CO—NH—NH2, —NR-L-OH, —NR-L-O-phosphoramidite, —NR-L-CHO, —NR-L-maleimid, or —NR-L-NH—CO—CH2—I; where R is equal to R1 and R2 and L is selected from the group consisting of a divalent linear (—(CH2)o—, o=1 to 15), crossed, or cyclic alkane group that can be substituted by at least one atom selected from the group consisting of oxygen, substituted ni
    Type: Application
    Filed: January 22, 2007
    Publication date: July 24, 2008
    Applicant: PIERCE BIOTECHNOLOGY, INC.
    Inventors: Wilhelm G. Frank, Matthias S. Wenzel, Peter T. Czerney, Surbhi Desai, Greg Hermanson