Patents by Inventor Wilhelm Kump
Wilhelm Kump has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5180718Abstract: The invention relates to novel acyl derivatives of rifamycins of the formula ##STR1## and the salts thereof, in which the structural elements --A.sub.1 --A.sub.2 --, --A.sub.3 --A.sub.4 -- and --A.sub.5 --A.sub.6 -- each denote ethylene or vinylene or the elements --A.sub.1 --A.sub.2 -- and --A.sub.3 --A.sub.4 -- each denote ethylene and --A.sub.5 --A.sub.6 -- denotes vinylene; X represents >C(R.sub.6)-- or >N-- and R.sub.6 denotes hydrogen or alkyl; alk denotes an aliphatic hydrocarbon radical; R.sub.1 denotes hydrogen or acyl; R.sub.2 denotes acyl, or alkyl which is optionally substituted by an aromatic radical, and R.sub.3 and R.sub.3 ' represent a common bond, or R.sub.3 denotes hydrogen or acyl, and R.sub.3 ' is hydrogen; R.sub.4 denotes hydrogen, cycloalkyl or aryl; R.sub.5 denotes hydrogen or acetyl; R.sub.7 denotes hydrogen or alkyl, which can be used as active compounds in medicaments, the preparation and use thereof, and pharmaceutical products and the preparation thereof.Type: GrantFiled: June 21, 1991Date of Patent: January 19, 1993Assignee: Ciba-Geigy CorporationInventors: Wilhelm Kump, Christian Borel, Jen Chen, Siem J. Veenstra, John Francis, Benjamin B. Mugrage
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Patent number: 5147870Abstract: The invention relates to the preparation of substituted azacyclohexyl derivatives of rifamycins of the formula ##STR1## and salts thereof in which R.sub.1 is hydrogen or trialkylacetyl, R.sub.2 is hydrogen or acetyl and R.sub.3 is alkyl, which exhibit valuable pharmacological properties.Type: GrantFiled: October 18, 1991Date of Patent: September 15, 1992Assignee: Ciba-Geigy CorporationInventors: Wilhelm Kump, Keith A. Menear
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Patent number: 5100894Abstract: Compounds of the general formula: ##STR1## in which R is a lower alkyl group, and R.sub.1 is a tri-lower alkylmethylcarbonyl group, the structure elements --A.sub.1 --A.sub.2 --, A.sub.3 --A.sub.4 -- or A.sub.5 --A.sub.6 -- each represent ethylene or vinylene, or the elements --A.sub.1 --A.sub.2 -- and --A.sub.3 --A.sub.4 -- each represent ethylene and --A.sub.5 --A.sub.6 -- represents vinylene, their optical isomers and their salts exhibit valuable pharmaceutical properties.Type: GrantFiled: April 12, 1991Date of Patent: March 31, 1992Assignee: Ciba-Geigy CorporationInventors: Peter W. Taylor, Ian T. W. Matthews, Jane I. Lowrie, Keith A. Menear, Wilhelm Kump
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Patent number: 5053510Abstract: The invention relates to a process for the preparation of a compound of formula ##STR1## or a salt thereof, wherein R.sub.1 is hydrogen or trialkylacetyl, R.sub.2 is hydrogen or acetyl and R.sub.3 is alkyl, which process comprises cyclising a compound of formula ##STR2## wherein R.sub.1 is trialkylacetyl and, if desired, converting a compound of formula I obtainable by said process or in another manner, or a salt thereof, into another compound of formula I or a salt thereof, or converting a resultant free compound of formula I into a salt and/or a resultant salt into the free compound of formula I or into another salt.Type: GrantFiled: April 18, 1990Date of Patent: October 1, 1991Assignee: Ciba-Geigy CorporationInventor: Wilhelm Kump
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Patent number: 5003070Abstract: The invention relates to novel substituted azacyclohexyl derivatives of formula ##STR1## and salts of thereof in which the structural elements --A.sub.1 -A.sub.2, --A.sub.3 -A.sub.4 -- and --A.sub.5 -A.sub.6 -- are each ethylene or vinylene or the elements --A.sub.1 -A.sub.2 -- and --A.sub.3 -A.sub.4 -- are each ethylene and --A.sub.5 -A.sub.6 -- is vinylene, X is >CR.sub.6 -- or >N-- and R.sub.6 is alkyl or hydrogen, alk is an aliphatic hydrocarbon radical or a bond, R.sub.1 is hydrogen or acyl, R.sub.2 is hydrogen or acetyl, R.sub.3 and R.sub.4 together are a bond or each is hydrogen, R.sub.5 is hydrogen, a cycloaliphatic hydrocarbon radical, aryl or heteroaryl and R.sub.7 is hydrogen or alkyl, with the proviso that when --A.sub.1 -A.sub.2 --, --A.sub.3 -A.sub.4 -- and --A.sub.5 -A.sub.6 -- are each vinylene, X is >N--, R.sub.1 is hydrogen or trialkylacetyl, R.sub.2 is hydrogen or acetyl, R.sub.3 and R.sub.4 together are a bond and alk is methylene, R.sub.Type: GrantFiled: April 26, 1989Date of Patent: March 26, 1991Assignee: Ciba-Geigy CorporationInventors: Wilhelm Kump, Jen Chen
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Patent number: 4918066Abstract: 3-W-Rifamycin SV and S compound, wherein W is a piperazin-1-yl radical of the formula ##STR1## wherein R.sup.1 and R.sup.2 are C.sub.1 -C.sub.4 alkyl and R.sup.3, R.sup.4 and R.sup.5 are hydrogen or C.sub.1 -C.sub.4 alkyl, or R.sup.2 together with R.sup.3 or R.sup.3 together with R.sup.4 are buta-1,3-dien-1,4-ylene, trimethylene or tetramethylene, each of which is unsubstituted or substituted by C.sub.1 -C.sub.4 alkyl, and R.sup.1, R.sup.4 and R.sup.5 or R.sup.1, R.sup.2 and R.sup.5 are hydrogen or C.sub.1 -C.sub.4 alkyl, and salts thereof, have long-term antituberculotic and antimicrobial activity.Type: GrantFiled: January 11, 1989Date of Patent: April 17, 1990Assignee: Ciba-Geigy CorporationInventor: Wilhelm Kump
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Patent number: 4916126Abstract: Compounds of the formula ##STR1## in which R represents lower alkyl, R.sub.1 represents tri-lower alkylmethylcarbonyl, and one of the radicals R.sub.2 and R.sub.3 represents tri-lower alkylmethylcarbonyl and the other represents hydrogen, and salts thereof, exhibit hypo-lipidaemic properties.Type: GrantFiled: November 14, 1988Date of Patent: April 10, 1990Assignee: Ciba-Geigy CorporationInventors: Peter Traxler, Klaus Muller, Wilhelm Kump
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Patent number: 4876258Abstract: Rifamycin derivatives of formula ##STR1## wherein R is a radical of the formula ##STR2## in which R.sub.1 is an unsubstituted or substituted biphenylyl radical, and wherein X--X, Y--Y and Z--Z are each vinylene of the formula CH.dbd.CH, or wherein X--X and Y--Y are each ethylene of the formula CH.sub.2 --CH.sub.2 and Z--Z is ethylene or vinylene, and processes for the preparation thereof are described. These compounds can be used as antibacterial and antiviral medicaments.Type: GrantFiled: August 1, 1988Date of Patent: October 24, 1989Assignee: Ciba-Geigy CorporationInventors: Wilhelm Kump, Peter Traxler
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Patent number: 4379149Abstract: 3-Hydroxyrifamycin S and its new analogues with an etherified or esterified 3-hydroxyl group of the formula ##STR1## in which each of R and R' represents a hydrogen atom, or R' represents acetyl and R represents hydrogen, an optionally substituted hydrocarbyl or the acyl radical of a carboxylic acid, and also the corresponding compounds of the SV series, are obtained by a novel process in which 3-bromorifamycin S is treated with a reagent ROH, in which R has the meanings mentioned above, or with a salt thereof, in a neutral to weakly basic medium. The final products are primarily suitable as antibiotics for combating microbial infections and/or as intermediates for the manufacture of the same.Type: GrantFiled: September 22, 1981Date of Patent: April 5, 1983Assignee: Ciba-Geigy CorporationInventor: Wilhelm Kump
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Patent number: 4353826Abstract: Antibiotically active compounds derived from rifamycin S or from the corresponding hydroquinone, rifamycin SV, or from derivatives at least partially hydrogenated in positions 16, 17; 18, 19; 28, 29, such as the 16, 17; 18, 19--tetrahydro- or the 16, 17; 18, 19; 28, 29--hexahydro derivatives, which contain in position 3 a free or an aliphatically substituted amino group. The hydrocarbon radicals of the aliphatically substituted amino group can also be interrupted in their carbon chain by heteroatoms and/or be substituted by functional groups.A special group of these new compounds is represented by 3-amino derivatives as defined above, in which the amino group is a particular type of N-aza-cyclo-aliphatic radical unsubstituted by functional groups, and which has, in addition to the antibiotic action against sensitive microorganisms also an antibacterial activity against certain types of resistant microorganisms.Type: GrantFiled: September 30, 1980Date of Patent: October 12, 1982Assignee: Ciba-Geigy CorporationInventors: Hans Bickel, Wilhelm Kump
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Patent number: 4322419Abstract: Derivatives of 5-norbicyclomycin of the formula ##STR1## wherein R represents an unsubstituted or substituted monovalent hydrocarbon radical in which one, two or more carbon atoms can be replaced by heteroatoms, and X represents a bivalent group of the formula --O-- or --N(R')--, wherein R' has one of the meanings assigned to R, whilst R and R', if both have a meaning which is different from hydrogen, can also be linked to each other through a C--C bond or an oxygen, sulphur or nitrogen atom, and corresponding compounds, in which at least one hydroxyl group is protected, and salts of said compounds, provided they contain salt-forming groups, are useful as antibiotics, especially against Enterobacteriaceae, or as intermediates for the production of such antibiotics. They are obtained by condensing a corresponding 5-norbicyclomycin-5-one with a compound of the formula R--X--NH.sub.2 in which X and R have the above meaning.Type: GrantFiled: January 8, 1979Date of Patent: March 30, 1982Assignee: Ciba-Geigy CorporationInventors: Beat Muller, Wilhelm Kump, Oskar Wacker
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Patent number: 4261891Abstract: Antibiotically active compounds derived from rifamycin S or from the corresponding hydroquinone, rifamycin SV, or from derivatives at least partially hydrogenated in positions 16, 17; 18, 19; 28, 29, such as the 16, 17; 18, 19-tetrahydro-or the 16, 17; 18, 19; 28, 29-hexahydro derivatives, which contain in position 3 a free or an aliphatically substituted amino group. The hydrocarbon radicals of the aliphatically substituted amino group can also be interrupted in their carbon chain by heteroatoms and/or be substituted by functional groups.A special group of these new compounds is represented by 3-amino derivatives as defined above, in which the amino group is a particular type of N-aza-cyclo-aliphatic radical unsubstituted by functional groups, and which has, in addition to the antibiotic action against sensitive microorganisms also an antibacterial activity against certain types of resistant microorganisms.Type: GrantFiled: April 19, 1979Date of Patent: April 14, 1981Assignee: Ciba-Geigy CorporationInventors: Hans Bickel, Wilhelm Kump
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Patent number: 4145344Abstract: Bicyclomycin derivatives (i.e. compounds with the skeleton of the 5-methylene-2-oxa-7,9-diazabicyclo?4,2,2!decane) of the formula ##STR1## wherein R.sup.a to R.sub.d represent hydrogen atoms or hydroxyl protective groups, X represents a free or functionally modified carboxyl group, a substituted or unsubstituted hydrocarbon radical or a halogen atom, and n is 0 or 1, possess valuable antibiotic properties which are of importance in particular for combating infections caused by Enterobacteriaceae and Proteus species.Type: GrantFiled: July 20, 1977Date of Patent: March 20, 1979Assignee: Ciba-Geigy CorporationInventors: Beat Muller, Wilhelm Kump, Oskar Wacker
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Patent number: 4005077Abstract: Antibiotically active compounds derived from rifamycin S or from the corresponding hydroquinone, rifamycin SV, or from derivatives at least partially hydrogenated in positions 16, 17; 18, 19; 28, 29, such as the 16, 17; 18, 19 - tetrahydro- or the 16, 17; 18, 19; 28, 29 - hexahydro derivatives, which contain in position 3 a free or an aliphatically substituted amino group. The hydrocarbon radicals of the aliphatically substituted amino group can also be interrupted in their carbon chain by heteroatoms and/or be substituted by functional groups.A special group of these new compounds is represented by 3-amino derivatives as defined above, in which the amino group is a particular type of N- aza - cyclo - aliphatic radical unsubstituted by functional groups, and which has, in addition to the antibiotic action against sensitive microorganisms also an antibacterial activity against certain types of resistant microorganisms.Type: GrantFiled: September 25, 1974Date of Patent: January 25, 1977Assignee: Ciba-Geigy CorporationInventors: Hans Bickel, Wilhelm Kump