Abstract: The invention is in the field of molecular diagnosis of medical diseases and their treatment. More in particular, it provides methods and means for detecting hypertension, more in particular essential primary hypertension, even more in particular NOX5-dependent hypertension. The invention also provides methods for the treatment of hypertension, in particular essential primary hypertension, more in particular NOX5-dependent hypertension. The invention also provides theragnostics, wherein therapy is combined with diagnosis, more in particular wherein the level of NOX5 is determined in a sample from a subject and wherein the subject is treated with NOX5 inhibitors or compounds that decrease the levels of NOX5 if the NOX5 levels are above a certain threshold value.

Abstract: The invention relates to a pharmaceutical composition comprising one or more stimulators of soluble guanylate cyclase (sGC), or a combination of at least one stimulator of sGC and at least one activator of sGC, for use in a method of treatment of a disease and/or a disorder that is/are associated with a deficiency of cyclic 3?,5?-guanosine monophosphate in the patient to be treated. The invention also relates to a therapeutic combination comprising a first unit dose comprising an sGC stimulator and a second unit dose comprising an sGC activator. The invention also relates to a therapeutic combination comprising a first unit dose comprising a first sGC stimulator and a second unit dose comprising a second sGC stimulator, for use in a method for the treatment of a disease and/or a disorder that is/are associated with a deficiency of cyclic 3?,5?-guanosine monophosphate in the patient to be treated.

Abstract: The present invention relates to a therapeutic combination comprising two or three of at least one NADPH oxidase inhibitor, at least one nitric oxide synthase inhibitor and at least one soluble guanylate cyclase agonist. More specifically, the invention relates to said therapeutic combination for use in the prevention or treatment of brain ischemia or for use in the prevention or treatment of ischemia-reperfusion injury. The invention also relates to a pharmaceutical composition comprising two or three of at least one NADPH oxidase inhibitor, at least one nitric oxide synthase inhibitor and at least one soluble guanylate cyclase agonist, and to said pharmaceutical composition for use in the prevention or treatment of brain ischemia or for use in the prevention or treatment of ischemia-reperfusion injury.

Abstract: The invention is in the field of molecular diagnosis of medical diseases and their treatment. More in particular, it provides methods and means for detecting hypertension, more in particular essential primary hypertension, even more in particular NOX5-dependent hypertension. The invention also provides methods for the treatment of hypertension, in particular essential primary hypertension, more in particular NOX5-dependent hypertension. The invention also provides theragnostics, wherein therapy is combined with diagnosis, more in particular wherein the level of NOX5 is determined in a sample from a subject and wherein the subject is treated with NOX5 inhibitors or compounds that decrease the levels of NOX5 if the NOX5 levels are above a certain threshold value.

Abstract: A lift truck or an attachment for a lift truck incorporating a rotating device with which loads are to be transported on or between receiving elements, particularly between two clamping jaws (15), whereby said loads can be held in various orientations, is characterised in that the rotating device (30) is rotatable in both directions and by more than 180°, in that a hydraulic fluid (31) is provided for the drive means for producing the rotary movement, in that one or more cam members (40) are arranged on the rotating member of the rotating device (30), in that one or more elements (41) are arranged on the fixed parts of the lift truck (10) or the attachment (14) opposite the rotating device (30) at those particular locations through which the cam member (40) or the cam members on the rotating device (30) pass shortly before the arrival thereof at the two vertical positions of the rotating device, in that the cam members (40) thereby actuate the elements (41) and in that a signal is produced by virtue of th

Abstract: The invention relates to a process for the preparation of a metal complex dye under production conditions, which comprises reacting at least one dye with a metal donor, adding said metal donor or said dye discontinuously before the end point of the metallizing is reached, and determining the end of the metallizing voltametrically.The process makes it possible to prepare metal complex dyes in good yield and purity.

Abstract: A process for controlling and optimizing chemical industrial processes for the preparation of dyes, fluorescent whitening agents and their intermediates, which process comprises controlling and optimizing those processes by differential analysis of the UV/VIS absorption spectra of at least one starting compound and of at least one reaction product. The advantage of this process is that the actual state of a process can be constantly measured, assessed, and used for feed-back and feed-forward control.

Abstract: An apparatus for the detection of chemical equalization processes in aqueous solutions, in particular for the determination of pH values and/or redox potentials, is described. The apparatus, a so-called interchangeable probe, includes an essentially cylindrical probe body, with a calibrating chamber and with an immersion pipe axially displaceable in a bore of the probe body and having at its front end a protective cylinder, the area adjacent to the immersion pipe being perforated in a basket-like manner. An electrode is set into the immersion pipe with the head of the electrode being located within the basket like perforated area of the protective cylinder. An annular gap between the immersion pipe and the inner wall of the probe body is sealed by at least three gaskets, located on the inner wall of the probe body.

Abstract: Two prismatic wedges of a prismatic compensator are rotated in opposite directions by the same angular quantity for adjusting the prismatic effect with the aid of a crossed-over pull wire. The pull wire is changed in direction by means of two rollers. The pull wire encloses the fittings under pulling tension so as to be free of slippage and free of play.

Abstract: A device for sharp-edge uniform illumination of an observation field lying in a preselectable plane is adapted to utilize light from a remote source, via a flexible fiber-optic connection having a glass-rod termination for producing a uniformly illuminated light-exit surface. The glass rod is insertably connected to the device via clamping mechanism (9, 10) in such manner that its light-radiating surface is immediately adjacent to a diaphragm (7). In front of the diaphragm (7), a collector (2, 3) is fixedly positioned, to focus the diaphragm as a real image in the observation plane. The diaphragm (7) (together with the glass rod) is displaceable axially with respect to the collector (2, 3), thus enabling sharp adjustment for different distances from the observation plane.

Abstract: A vehicle for removing slash from steep logging slopes includes an anti-skid propulsion system characterized by a power winch for reeling in an uphill-anchored cable and a pair of crawler tracks driven in synchronization with the winch. The vehicle has an articulating tail boom for working against the cable to assist in maneuvering the vehicle along the slope and stabilizing the vehicle during slash gathering operations. A knuckle boom which is extendable from the vehicle for gathering slash within a relatively large area around the vehicle and preparing the soil for planting. A slide mechanism is disposed at the end of the knuckle boom for selectively varying the overall length of the boom. The slide mechanism includes a pair of claws which can be operated as a grapple for gathering slash or as a rake for scarifying the forest soil. The slide mechanism can be tilted for optimum orientation of the claws during raking.

Abstract: The invention contemplates a binocular observation instrument wherein two viewing tubes are pivotally connected for articulation about a first axis to adjust for interpupilary distance and wherein provision is made for further articulation about a second axis to enable adjustment of the angle between the respective optical axes of the two viewing tubes.

Abstract: The invention contemplates a binocular-telescope construction wherein no precision optical alignment or realignment procedures are needed within the telescope tubes, once the telescope tubes are assembled to their connecting bridge structure. The nature of the connecting bridge structure is such as to provide a range of universal action in the connection of each telescope tube to the bridge structure so that optical-axis parallelism can be mechanically effected and clamped at the universal connections without operating upon any of the individual optical elements within the telescope tube. The universal action and clamping is without prejudice to the single-articulated or double-articulated nature and action of the connecting bridge, for interpupilary-distance accommodation.

Abstract: A composite body having a portion of a thermosetting material and a portion of a thermoplastics material is formed by including a layer of fabric having a serrated surface between the two portions as a connecting means. The fabric with its serrated surface facing outwards is applied to an area of a thermosetting material after which a thermoplastics material in particulate form is intimately mixed into the serrations of the fabric. The composite body, such as a weaving shuttle, is then pressed, fused and cured.

Abstract: An articulated frame log skidder having front and rear wheeled chassis separated by an oscillating suspension which allows the front chassis to rotate with respect to the rear chassis. The axis of rotation between the front and rear chassis is inclined upwardly toward the front of the skidder so that it passes above the center of gravity of the front chassis. Thus, as an excessive force exerted on a rear chassis winch lifts the front wheels above the vehicle-supporting surface, the front chassis remains in a stable condition with its center of gravity beneath the axis of rotation. A horizontal force applied to one of the wheels when the wheel strikes an obstruction is transformed by the inclined axis of rotation into a rotational moment about the axis which lifts the wheel over the obstruction.

Abstract: A paper-clip dispenser has an upwardly open receptacle with a hole in its bottom through which a stem carrying a magnet passes. When the receptacle is lifted, the stem falls under its own weight or with the aid of a spring to bring the magnet of its upper end into a collection of paper clips at the bottom of the dispenser. When the dispenser is again placed upon the surface of a table or desk, the upper end of the stem is displaced upwardly to carry paper clips through the opening in the receptacle and enable them to be drawn off the magnet one at a time as required by the user.

Abstract: A weaving shuttle having a metal or wood winding core is shown. The core is wrapped with alternating hardened layers of fabric soaked with plastic, and plywood. Preferably, the direction of the warp threads in the fabric layers alternate between running parallel to the longitudinal axis of the weaving shuttle and perpendicular thereto, except for the outermost layers where only fabric course sheets are present in which the warp threads run parallel to the longitudinal axis of the shuttle.