Abstract: Disclosed herein are methods for selecting tumor-specific neoantigens from a tumor of a subject that are suitable for subject-specific immunogenic compositions.

Abstract: Disclosed herein are methods for selecting one or more tumor-specific neoantigens from a tumor of a subject for a personalized immunogenic composition. Also disclosed herein are methods for treating cancer in a subject in need thereof by administering an immunogenic composition comprising tumor-specific neoantigens selected using the methods disclosed herein.

Abstract: Provided herein are immunogenic compositions comprising tumor-specific neoantigen long peptides, tumor-specific neoantigen short peptides, and adjuvant, optionally a helper peptide, and optionally a tumor-specific peptide. The disclosure also provides methods of using these immunogenic compositions for treating cancer.

Abstract: Disclosed herein are methods for ranking tumor-specific neoantigens from a tumor of a subject that are suitable for subject-specific immunogenic compositions. Suitable tumor-specific neoantigens are tumor-specific neoantigens that are likely presented on the cell surface of the tumor, are likely to be immunogenic, are predicted to be expressed in sufficient amounts to elicit an immune response in the subject, optionally represent sufficient diversity across the tumor, and have relatively high manufacture feasibility. The present methods take a set of neoantigens (peptide vaccine candidates) and ranks the neoantigens in a way such that a group of top-ranked neoantigens simultaneously promotes cell-surface presentation of important neoantigens for Class I and Class II MHC molecules. The top-ranked neoantigens can then be further narrowed according manufacturability and/or other criteria.

Abstract: A thermoplastic polyurethane resin composition comprising: a thermoplastic polyurethane resin; an ultraviolet absorber package comprising a benzotriazole compound (UVA1), and a triazine compound (UVA2) wherein the mass ratio of UVA1 to UVA2 is from 1:1 to 3:1; optionally, a hindered amine light stabilizer and/or an antioxidant compound; and wherein the thermoplastic polyurethane resin composition has a maximum ultraviolet transmittance of ?3% in the wavelengths between 280 nm and 365 nm and an ultraviolet transmittance of ?6% in the wavelengths between 365 nm and 370 nm when the thermoplastic polyurethane resin is formed into a film having a thickness of 6 mils and wherein the cumulative weight % of UVA1 and UVA2 in the polyurethane resin composition ranges from 0.5 wt % to 0.85 wt % based on the total weight of the polyurethane resin composition.

Abstract: An apparatus for continuously casting thin strip has a pair of internally cooled counter-rotatable casting rolls having casting surfaces, the pair of casting rolls laterally positioned to form a gap at a nip between the casting rolls through which a thin metal strip can be cast, where the casting surface of each casting roll has a roll profile extending in an axial direction of the corresponding casting roll; a metal delivery system adapted to deliver molten metal above the nip to form a casting pool; and a temperature altering source external to the casting roll and having one or more zones configured to alter the casting roll profile of at least one of the pair of casting rolls by locally heating or cooling the casting roll.

Abstract: Techniques are described and relate to assigning peptides to peptide groups for vaccine development. In an example, a peptide property of a peptide is determined, where this peptide is from different peptides that are to be assigned to different groups of vaccine. A determination is also made that the peptide is to be assigned to a first group from the different groups based at least in part on the peptide property. The first group has a first group property that is based at least in part on peptide properties of first peptides to be assigned to the first group. The first group property is within a similarity range relative to a second group property of a second group from the different groups. Information is generated and indicates that the peptide is assigned to the first group.

Abstract: An apparatus for continuously casting thin strip comprises a pair of internally cooled counter-rotatable casting rolls having casting surfaces, the pair of casting rolls laterally positioned to form a gap at a nip between the casting rolls through which a thin metal strip can be cast, where the casting surface of each casting roll has a roll profile extending in an axial direction of the corresponding casting roll; a metal delivery system adapted to deliver molten metal above the nip to form a casting pool; and a temperature altering source external to the casting roll and having one or more zones configured to alter the casting roll profile of at least one of the pair of casting rolls by locally heating or cooling the casting roll.

Abstract: An alkali metal-based energy storage system, having at least one composite electrode containing an active material, and an electrolyte containing a lithium salt dissolved in an aprotic organic solvent, an ionic fluid and/or a polymer matrix. The electrolyte further contains an additive selected from a cation or a compound of a metal selected from Mg, Al, Cu and/or Cr. The metal selected from Mg, Al, Cu and/or Cr is applied onto the active material and/or the active material of the composite electrode is partially replaced by the metal selected from Mg, Al, Cu and/or Cr in the form of a metal powder or a metal salt.

Abstract: A method for producing a cast strip of molten metal, in which the molten metal passes through a casting gap defined by two oppositely rotating casting rollers and is shaped into the cast strip, as well as the cast strip that is produced. By providing the cast strip in the casting gap with a different thickness in a first length section extending in the longitudinal direction of the cast strip than in a second length section bordering thereon, a metal strip is produced that has length sections with different thicknesses.

Abstract: The present invention provides a compound with a general formula (I) or a salt thereof, wherein, R1 and R2, are, independently of each other, F or CnF2n+1 with n=1-10, and R3 and R4 are, independently of each other, C1-C10-alkyl.

Abstract: The invention relates to lithium 1-trifluoromethoxy-1,2,2,2-tetra-fluoroethanesulphonate, the use of lithium 1-trifluoromethoxy-1,2,2,2-tetra-fluoroethanesulphonate as electrolyte salt in lithium-based energy stores and also ionic liquids comprising 1-trifluoro-methoxy-1,2,2,2-tetrafluoro-ethanesulphonate as anion.

Abstract: An alkali metal-based energy storage system, having at least one composite electrode containing an active material, and an electrolyte containing a lithium salt dissolved in an aprotic organic solvent, an ionic fluid and/or a polymer matrix. The electrolyte further contains an additive selected from a cation or a compound of a metal selected from Mg, Al, Cu and/or Cr. The metal selected from Mg, Al, Cu and/or Cr is applied onto the active material and/or the active material of the composite electrode is partially replaced by the metal selected from Mg, Al, Cu and/or Cr in the form of a metal powder or a metal salt.

Abstract: The invention relates to the use of lithium-2-pentafluoroethoxy-1,1,2,2-tetrafluoro-ethanesulfonate as a conductive salt in lithium-based energy stores and to electrolytes containing lithium-2-pentafluoroethoxy-1,1,2,2-tetrafluoro-ethanesulfonate.

Abstract: The invention relates to lithium-2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate, to the use thereof as conductive salt in lithium-based energy accumulators, and ionic liquids comprising 2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate as an anion.

Abstract: A method for producing a cast strip of molten metal, in which the molten metal passes through a casting gap defined by two oppositely rotating casting rollers and is shaped into the cast strip, as well as to a cast strip. The inventive method makes it possible to produce a metal strip that has length sections with different thicknesses. According to the invention, this is achieved in that the cast strip is in the casting gap provided with a different thickness in a length section extending in the longitudinal direction of the cast strip than in a second length section bordering thereon.

Abstract: The present invention provides a compound with a general formula (I) or a salt thereof, wherein, R1 and R2, are, independently of each other, F or CnF2n+1 with n=1-10, and R3 and R4 are, independently of each other, C1-C10-alkyl.

Abstract: The invention relates to lithium 1-trifluoromethoxy-1,2,2,2-tetra-fluoroethanesulphonate, the use of lithium 1-trifluoromethoxy-1,2,2,2-tetra-fluoroethanesulphonate as electrolyte salt in lithium-based energy stores and also ionic liquids comprising 1-trifluoro-methoxy-1,2,2,2-tetrafluoro-ethanesulphonate as anion.

Abstract: The invention relates to the use of lithium-2-pentafluoroethoxy-1,1,2,2-tetrafluoro-ethanesulfonate as a conductive salt in lithium-based energy stores and to electrolytes containing lithium-2-pentafluoroethoxy-1,1,2,2-tetrafluoro-ethanesulfonate.

Abstract: The invention relates to lithium-2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate, to the use thereof as conductive salt in lithium-based energy accumulators, and ionic liquids comprising 2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate as an anion.