Patents by Inventor Wilhelm T. S. Huck
Wilhelm T. S. Huck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9707557Abstract: We describe a method of layer-by-layer deposition of a plurality of layers of material onto the wall or walls of a channel of a microfluidic device, the method comprising: loading a tube with a series of segments of solution, a said segment of solution bearing a material to be deposited; coupling said tube to said microfluidic device; and injecting said segments of solution into said microfluidic device such that said segments of solution pass, in turn, through said channel depositing successive layers of material to perform said layer-by-layer deposition onto said wall or walls of said channel. Embodiments of the methods are particularly useful for automated surface modification of plastic, for example PDMS (Poly(dimethylsiloxane)), microchannels. We also describe methods and apparatus for forming double-emulsions.Type: GrantFiled: September 15, 2014Date of Patent: July 18, 2017Assignee: Cambridge Enterprise LimitedInventors: Wolfgang Andreas Bauer, Wilhelm T. S. Huck, Martin Fischlechner
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Patent number: 9490111Abstract: Systems that employ microdroplets are used in embodiments for Microdroplet Electrospray Ionisation Mass Spectrometry (ESI MS). Thus, a method of detecting an analyte includes providing an oil composition comprising oil and an aqueous microdroplet comprising the analyte, the oil composition comprising a surfactant to stabilise the aqueous microdroplet in the oil composition; and performing ionisation mass spectrometry analysis of the oil composition.Type: GrantFiled: June 30, 2011Date of Patent: November 8, 2016Assignee: CAMBRIDGE ENTERPRISE LIMITEDInventors: Christopher Abell, Wilhelm T. S. Huck, Timothy Sharpe, Clive Smith, Todd Mize, Carol Robinson, Xin Li
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Patent number: 9422067Abstract: This invention relates to methods and systems for providing chemical and/or biological materials. Thus we describe a method of providing a chemical or biological material in a quantized form, the method comprising: preparing an emulsion comprising a plurality of microdroplets each holding a controlled amount of said material; storing said chemical or biological material in said microdroplets in said emulsion; transferring a portion of said emulsion microdroplets to a container for transportation; transporting said container to a user of said material, wherein said user receives said material in a quantized form in said microdroplets of said emulsion; and de-emulsifying said received microdroplets containing said material in quantized form to extract said material for subsequent use.Type: GrantFiled: August 17, 2011Date of Patent: August 23, 2016Assignee: SPHERE FLUIDICS LIMITEDInventors: Chris Abell, Wilhelm T. S. Huck, Frank F. Craig
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Publication number: 20150073061Abstract: We describe a method of layer-by-layer deposition of a plurality of layers of material onto the wall or walls of a channel of a microfluidic device, the method comprising: loading a tube with a series of segments of solution, a said segment of solution bearing a material to be deposited; coupling said tube to said microfluidic device; and injecting said segments of solution into said microfluidic device such that said segments of solution pass, in turn, through said channel depositing successive layers of material to perform said layer-by-layer deposition onto said wall or walls of said channel. Embodiments of the methods are particularly useful for automated surface modification of plastic, for example PDMS (Poly(dimethylsiloxane)), microchannels. We also describe methods and apparatus for forming double-emulsions.Type: ApplicationFiled: September 15, 2014Publication date: March 12, 2015Applicant: Cambridge Enterprise LimitedInventors: Wolfgang Andreas BAUER, Wilhelm T.S. HUCK, Martin FISCHLECHNER
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Patent number: 8834966Abstract: We describe a method of layer-by-layer deposition of a plurality of layers of material onto the wall or walls of a channel of a microfluidic device, the method comprising: loading a tube with a series of segments of solution, a said segment of solution bearing a material to be deposited; coupling said tube to said microfluidic device; and injecting said segments of solution into said microfluidic device such that said segments of solution pass, in turn, through said channel depositing successive layers of material to perform said layer-by-layer deposition onto said wall or walls of said channel. Embodiments of the methods are particularly useful for automated surface modification of plastic, for example PDMS (Poly(dimethylsiloxane)), microchannels. We also describe methods and apparatus for forming double-emulsions.Type: GrantFiled: July 2, 2010Date of Patent: September 16, 2014Assignee: Cambridge Enterprise LimitedInventors: Wolfgang Andreas Bauer, Wilhelm T. S. Huck, Martin Fischlechner
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Patent number: 8828210Abstract: This invention relates to microfluidic systems and more particularly to methods and apparatus for accessing the contents of micro droplets (114) in an emulsion stream. A method of accessing the contents of a droplet (114) of an emulsion in a microfluidic system, the method comprising: flowing the emulsion alongside a continuous, non-emulsive stream of second fluid (118) to provide an interface (120) between said emulsion and said stream of second fluid (118); and in embodiments applying one or both of an electric (112a, 112b) and magnetic field across said interface (120) to alter a trajectory of a said droplet (114) of said emulsion to cause said droplet to coalesce with said stream of second fluid (118); and accessing said contents of said droplet (114) in said second stream (118).Type: GrantFiled: October 16, 2008Date of Patent: September 9, 2014Assignee: Cambridge Enterprise LimitedInventors: Chris Abell, Wilhelm T. S. Huck, Daniel Bratton, Graeme Whyte, Luis M. Fidalgo
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Publication number: 20130187040Abstract: Systems that employ microdroplets are used in embodiments for Microdroplet Electrospray Ionisation Mass Spectrometry (ESI MS). Thus, a method of detecting an analyte includes providing an oil composition comprising oil and an aqueous microdroplet comprising the analyte, the oil composition comprising a surfactant to stabilise the aqueous microdroplet in the oil composition; and performing ionisation mass spectrometry analysis of the oil composition.Type: ApplicationFiled: June 30, 2011Publication date: July 25, 2013Applicant: CAMBRIDGE ENTERPRISE LIMITEDInventors: Christopher Abell, Wilhelm T.S. Huck, Timothy Sharpe, Clive Smith, Todd Mize, Carol Robinson, Xin Li
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Publication number: 20130139477Abstract: This invention relates to methods and systems for providing chemical and/or biological materials. Thus we describe a method of providing a chemical or biological material in a quantised form, the method comprising: preparing an emulsion comprising a plurality of microdroplets each holding a controlled amount of said material; storing said chemical or biological material in said microdroplets in said emulsion; transferring a portion of said emulsion microdroplets to a container for transportation; transporting said container to a user of said material, wherein said user receives said material in a quantised form in said microdroplets of said emulsion; and de-emulsifying said received microdroplets containing said material in quantised form to extract said material for subsequent use.Type: ApplicationFiled: August 17, 2011Publication date: June 6, 2013Applicants: CAMBRIDGE ENTERPRISE LIMITED, SPHERE FLUIDICS LIMITEDInventors: Chris Abell, Wilhelm T.S. Huck, Frank F. Craig
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Patent number: 8377635Abstract: A method of controlling the flow of an aqueous fluid in a microfluidic device, which makes use of a fluid gate comprising a UCST (upper critical solubility temperature) polymer and which allows fluid to flow by raising the temperature of the fluid gate above the USCT. Also provided is a device incorporating such a fluid gate and the use of such a device to detect an analyte in an aqueous fluid sample.Type: GrantFiled: February 12, 2007Date of Patent: February 19, 2013Assignee: Alere Switzerland GmbHInventors: Andrew Antony Brown, Omar Azzaroni, Wilhelm T. S. Huck
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Publication number: 20120168010Abstract: We describe a method of layer-by-layer deposition of a plurality of layers of material onto the wall or walls of a channel of a microfluidic device, the method comprising: loading a tube with a series of segments of solution, a said segment of solution bearing a material to be deposited; coupling said tube to said microfluidic device; and injecting said segments of solution into said microfluidic device such that said segments of solution pass, in turn, through said channel depositing successive layers of material to perform said layer-by-layer deposition onto said wall or walls of said channel. Embodiments of the methods are particularly useful for automated surface modification of plastic, for example PDMS (Poly(dimethylsiloxane)), microchannels. We also describe methods and apparatus for forming double-emulsions.Type: ApplicationFiled: July 2, 2010Publication date: July 5, 2012Inventors: Wolfgang Andreas Bauer, Wilhelm T.S. Huck, Martin Fischlechner
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Publication number: 20120091004Abstract: This invention relates to microfluidic systems and more particularly to methods and apparatus for accessing the contents of micro droplets (114) in an emulsion stream. A method of accessing the contents of a droplet (114) of an emulsion in a microfluidic system, the method comprising: flowing the emulsion alongside a continuous, non-emulsive stream of second fluid (118) to provide an interface (120) between said emulsion and said stream of second fluid (118); and in embodiments applying one or both of an electric (112a, 112b) and magnetic field across said interface (120) to alter a trajectory of a said droplet (114) of said emulsion to cause said droplet to coalesce with said stream of second fluid (118); and accessing said contents of said droplet (114) in said second stream (118).Type: ApplicationFiled: October 16, 2008Publication date: April 19, 2012Inventors: Chris Abell, Wilhelm T.S. Huck, Daniel Bratton, Graeme Whyte, Luis M. Fidalgo
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Publication number: 20100210037Abstract: A method of controlling the flow of an aqueous fluid in a microfluidic device, which makes use of a fluid gate comprising a UCST (upper critical solubility temperature) polymer and which allows fluid to flow by raising the temperature of the fluid gate above the USCT. Also provided is a device incorporating such a fluid gate and the use of such a device to detect an analyte in an aqueous fluid sample.Type: ApplicationFiled: February 12, 2007Publication date: August 19, 2010Inventors: Andrew Antony Brown, Omar Azzaroni, Wilhelm T.S. Huck