Patents by Inventor Wilhelmus Everhardus Hennink
Wilhelmus Everhardus Hennink has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230201799Abstract: The present invention relates to a method for preparing a macromolecular composition comprising indene-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules.Type: ApplicationFiled: February 10, 2023Publication date: June 29, 2023Applicants: Stichting voor de Technische Wetenschappen, Universiteit Utrecht Holding B.V., UMC Utrecht Holding B.V.Inventors: Robert Smakman, Wilhelmus Everhardus Hennink, Karin Gerarda Frederika Gerritsen, Jacobus Adrianus Wilhelmus Jong, Cornelus Franciscus van Nostrum
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Patent number: 11612877Abstract: The present invention relates to a method for preparing a macromolecular composition comprising indene-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules.Type: GrantFiled: December 4, 2018Date of Patent: March 28, 2023Assignees: Stichting voor de Technische Wetenschappen, Universiteit Utrecht Holding B.V., UMC Utrecht Holding B.V.Inventors: Robert Smakman, Wilhelmus Everhardus Hennink, Karin Gerarda Frederika Gerritsen, Jacobus Adrianus Wilhelmus Jong, Cornelus Franciscus van Nostrum
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Publication number: 20230046628Abstract: The present invention relates to a method for preparing a macromolecular composition comprising phenylglyoxaldehyde-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules, for instance to remove such small molecules from a solution.Type: ApplicationFiled: November 20, 2020Publication date: February 16, 2023Applicants: Stichting voor de Technische Wetenschappen, Universiteit Utrecht Holding B.V., UMC Utrecht Holding B.V.Inventors: Robert Smakman, Wilhelmus Everhardus Hennink, Karin Gerarda Frederika Gerritsen, Jacobus Adrianus Wilhelmus Jong, Cornelus Franciscus van Nostrum
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Publication number: 20220401889Abstract: The present invention relates to a method for preparing a membrane comprising sorbent particles that bind urea. The invention also relates to the sorbent-comprising membranes per se, and to methods of using the membranes. The membranes are useful for undergoing subsequent reactions with small molecules such as urea, for instance to remove urea from a solution.Type: ApplicationFiled: November 20, 2020Publication date: December 22, 2022Applicants: Stichting voor de Technische Wetenschappen, UMC Utrecht Holding B.V., Universiteit Utrecht Holding B.V., Universiteit TwenteInventors: Dimitrios Stamatialis, Ilaria Geremia, Cornelus Franciscus van Nostrum, Karin Gerarda Frederika Gerritsen, Robert Smakman, Wilhelmus Everhardus Hennink, Jacobus Adrianus Wilhelmus Jong, Yong Guo
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Patent number: 11007148Abstract: The present invention provides an amphiphilic block copolymer for drug delivery and a controlled release system comprising the same copolymer. The copolymer comprises at least one hydrophilic block and at least one hydrophobic block, wherein the hydrophobic block is selected from the group consisting of acrylates, methacrylates, acrylamides, methacrylamides, vinylethers and their aromatic derivatives, wherein at least one hydrophobic block contains an aryl group, which is bound to the hydrophobic block with a degradable linker. The controlled release system of the invention shows high stability and high drug retention when administered in vivo enabling accumulation and drug release at the site of action.Type: GrantFiled: August 11, 2015Date of Patent: May 18, 2021Assignee: Rheinisch-Westfälische Technische Hochschule (RWTH) AachenInventors: Wilhelmus Everhardus Hennink, Yang Shi, Cornelus Franciscus van Nostrum
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Publication number: 20200368721Abstract: The present invention relates to a method for preparing a macromolecular composition comprising indene-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules.Type: ApplicationFiled: December 4, 2018Publication date: November 26, 2020Applicants: Stichting voor de Technische Wetenschappen, Universiteit Utrecht Holding B.V., UMC Utrecht Holding B.V.Inventors: Robert Smakman, Wilhelmus Everhardus Hennink, Karin Gerarda Frederika Gerritsen, Jacobus Adrianus Wilhelmus Jong, Cornelus Franciscus van Nostrum
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Publication number: 20170231908Abstract: The present invention provides an amphiphilic block copolymer for drug delivery and a controlled release system comprising the same copolymer. The copolymer comprises at least one hydrophilic block and at least one hydrophobic block, wherein the hydrophobic block is selected from the group consisting of acrylates, methacrylates, acrylamides, methacrylamides, vinylethers and their aromatic derivatives, wherein at least one hydrophobic block contains an aryl group, which is bound to the hydrophobic block with a degradable linker. The controlled release system of the invention shows high stability and high drug retention when administered in vivo enabling accumulation and drug release at the site of action.Type: ApplicationFiled: August 11, 2015Publication date: August 17, 2017Inventors: Wilhelmus Everhardus Hennink, Yang Shi, Cornelus Franciscus van Nostrum
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Patent number: 9339554Abstract: The present invention relates to a particular class of biodegradable linkers, ensuring transiently stable conjugation of building blocks and/or bioactive compounds into drug delivery systems (DDS), such as DDS based on polymeric micelles or hydrogels. In addition, the present invention relates to compounds, comprising said linkers, such compounds preferably being prodrugs. Further, the invention is directed to the use of said linkers, and especially said biodegradable linkers, in a drug delivery system. Moreover, the invention relates to controlled release system comprising a polymer matrix, capable of releasing an active ingredient, wherein the active ingredient is covalently linked to the polymer molecules of the polymer matrix through said linkers, as well as to a method of synthesizing these linkers and preparing such controlled release systems.Type: GrantFiled: July 14, 2011Date of Patent: May 17, 2016Assignee: CRISTAL DELIVERY B.V.Inventors: Cristianne Johanna Ferdinand Rijcken, Wilhelmus Everhardus Hennink, Cornelis Franciscus van Nostrum, Isil Altintas, Steffen van der Wal, Robertus Matthias Joseph Liskamp, Johannes Anna Wilhelmus Kruijtzer
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Patent number: 9289437Abstract: The present invention relates to a method for the preparation of a controlled release system and especially to a method for entrapment of compounds in polymer carriers for controlled release of active ingredients, preferably bioactive ingredients, such as drugs. This method results in a system for controlled release of active ingredients and especially for controlled drug delivery. In accordance with the present invention, the term “controlled release” encompasses all kinds of controlled release, including slow release, sustained and delayed release. Particularly, the present invention results in active ingredients, entrapped in or otherwise incorporated in or coupled to polymer carriers or polymeric devices, such as micelles, nanoparticles, microspheres and other types of polymer devices for controlled release; the active ingredients are covalently bonded to the polymer carriers or polymeric devices.Type: GrantFiled: February 20, 2014Date of Patent: March 22, 2016Assignee: CRISTAL DELIVERY B.V.Inventors: Cristianne Johanna Ferdinand Rijcken, Wilhelmus Everhardus Hennink, Cornelis Franciscus Van Nostrum
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Patent number: 8840951Abstract: The present invention relates to a method for the preparation of a controlled release system and especially to a method for entrapment of compounds in polymer carriers for controlled release of active ingredients, preferably bioactive ingredients, such as drugs. This method results in a system for controlled release of active ingredients and especially for controlled drug delivery. In accordance with the present invention, the tem controlled release” encompasses all kinds of controlled release, including slow release, sustained and delayed release. Particularly, the present invention results in active ingredients, entrapped in or otherwise incorporated in or coupled to polymer carriers or polymeric devices, such as micelles, nanoparticles, microspheres and other types of polymer devices for controlled release; the active ingredients are covalently bonded to the polymer carriers or polymeric devices.Type: GrantFiled: September 17, 2009Date of Patent: September 23, 2014Assignee: Cristal Delivery B.V.Inventors: Cristianne Johanna Ferdinand Rijcken, Wilhelmus Everhardus Hennink, Cornelis Franciscus Van Nostrum
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Publication number: 20140235799Abstract: The present invention relates to a method for the preparation of a controlled release system and especially to a method for entrapment of compounds in polymer carriers for controlled release of active ingredients, preferably bioactive ingredients, such as drugs. This method results in a system for controlled release of active ingredients and especially for controlled drug delivery. In accordance with the present invention, the term “controlled release” encompasses all kinds of controlled release, including slow release, sustained and delayed release. Particularly, the present invention results in active ingredients, entrapped in or otherwise incorporated in or coupled to polymer carriers or polymeric devices, such as micelles, nanoparticles, microspheres and other types of polymer devices for controlled release; the active ingredients are covalently bonded to the polymer carriers or polymeric devices.Type: ApplicationFiled: February 20, 2014Publication date: August 21, 2014Applicant: Universiteit Utrecht Holding B.V.Inventors: Cristianne Johanna Ferdinand RIJCKEN, Wilhelmus Everhardus HENNINK, Cornelis Franciscus VAN NOSTRUM
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Patent number: 8685382Abstract: The present invention relates to compositions comprising polymers whose solubility characteristics can be changed by incubation and particularly poly (hydroxyalkyl(meth) acrylamide mono/di-lactate_interpolymers. Another aspect of this invention is the application of such temperature sensitive polymers as release systems of biologically active compounds. The polymers of the present invention comprise monomers, which have modifiable functionality. The functionality of the monomers can for example be modified by the presence of hydrolysable groups. The modification is effected by the incubation, leading to a change of the water solubility characteristics of the polymer. The polymers used in the present invention contain hydrolysable chemical groups. As a result the polymer's solution characteristics, specifically its lower critical solution temperature (LCST), change upon incubation.Type: GrantFiled: September 23, 2011Date of Patent: April 1, 2014Assignee: Cristal Delivery B.V.Inventors: Wilhelmus Everhardus Hennink, Cornelis Franciscus Van Nostrum, Marinus Jacob Van Steenbergen, Osamu Soga, Cristianne Johanna Ferdinand Rijcken
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Publication number: 20130261094Abstract: The present invention relates to a particular class of biodegradable linkers, ensuring transiently stable conjugation of building blocks and/or bioactive compounds into drug delivery systems (DDS), such as DDS based on polymeric micelles or hydrogels. In addition, the present invention relates to compounds, comprising said linkers, such compounds preferably being prodrugs. Further, the invention is directed to the use of said linkers, and especially said biodegradable linkers, in a drug delivery system. Moreover, the invention relates to controlled release system comprising a polymer matrix, capable of releasing an active ingredient, wherein the active ingredient is covalently linked to the polymer molecules of the polymer matrix through said linkers, as well as to a method of synthesising these linkers and preparing such controlled release systems.Type: ApplicationFiled: July 14, 2011Publication date: October 3, 2013Applicant: Cristal Delivery B.V.Inventors: Cristianne Johanna Ferdinand Rijcken, Wilhelmus Everhardus Hennink, Cornelis Franciscus van Nostrum, Isil Altintas, Steffen van der Wal, Robertus Matthias Joseph Liskamp, Johannes Anna Wilhelmus Kruijtzer
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Patent number: 8357397Abstract: The invention relates to the field of pharmacology. More specific, the invention relates to a controlled release composition. In one of the embodiments, the invention provides a method for preparing a controlled release composition comprising the steps of: providing a mixture of a recombinant gelatin and a pharmaceutical chemically cross-linking said recombinant gelatin to obtain a three dimensional network structure.Type: GrantFiled: February 21, 2008Date of Patent: January 22, 2013Assignee: Fujifilm Manufacturing Europe B.V.Inventors: Jan Bastiaan Bouwstra, Marc Sutter, Sebastianus Gerardus Kluijtmans, Wilhelmus Everhardus Hennink, Wim Jiskoot
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Patent number: 8110220Abstract: The present invention relates to compositions comprising polymers whose solubility characteristics can be changed by incubation and particularly ploy (hydroxyalkyl (meth) acrylamide mono/di-lactate) interpolymers. Another aspect of this invention is the application of such temperature sensitive polymers as release systems of biologically active compounds. The polymers of the present invention comprise monomers, which have modifiable functionality. The functionality of the monomers can for example be modified by the presence of hydrolysable groups. The modification is effected by the incubation, leading to a change of the water solubility characteristics of the polymer. The polymers used in the present invention contain hydrolysable chemical groups. As a result the polymer's solution characteristics, specifically its lower critical solution temperature (LCST), change upon incubation.Type: GrantFiled: March 17, 2005Date of Patent: February 7, 2012Assignee: Universiteit UtrechtInventors: Wilhelmus Everhardus Hennink, Cornelis Franciscus Van Nostrum, Marinus Jacob Van Steenbergen, Osamu Soga, Cristianne Johanna Ferdinand Rijcken
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Patent number: 8101205Abstract: The invention relates to the field of pharmacology. More specific, the invention relates to a controlled release composition. This invention is related to a controlled release composition comprising a cross-linked gelatin and at least one therapeutic protein wherein the ratio of the average mesh size (?) of the gelatin matrix and the average hydrodynamic radius (RH) of the therapeutic protein is smaller than 2, preferably smaller than 1.5.Type: GrantFiled: February 21, 2008Date of Patent: January 24, 2012Assignee: Fujifilm Manufacturing Europe B.V.Inventors: Jan Bastiaan Bouwstra, Marc Sutter, Sebastianus Gerardus Kluijtmans, Wilhelmus Everhardus Hennink, Wim Jiskoot
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Publication number: 20120015034Abstract: The present invention relates to compositions comprising polymers whose solubility characteristics can be changed by incubation and particularly poly (hydroxyalkyl(meth) acrylamide mono/di-lactate interpolymers. Another aspect of this invention is the application of such temperature sensitive polymers as release systems of biologically active compounds. The polymers of the present invention comprise monomers, which have modifiable functionality. The functionality of the monomers can for example be modified by the presence of hydrolysable groups. The modification is effected by the incubation, leading to a change of the water solubility characteristics of the polymer. The polymers used in the present invention contain hydrolysable chemical groups. As a result the polymer's solution characteristics, specifically its lower critical solution temperature (LCST), change upon incubation.Type: ApplicationFiled: September 23, 2011Publication date: January 19, 2012Applicant: Universiteit UtrechtInventors: Wilhelmus Everhardus HENNINK, Cornelis Franciscus Van Nostrum, Marinus Jacob Van Steenbergen, Osamu Soga, Cristianne Johanna Derdinand Rijcken
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Publication number: 20110217448Abstract: The present invention relates to a method for the preparation of a controlled release system and especially to a method for entrapment of compounds in polymer carriers for controlled release of active ingredients, preferably bioactive ingredients, such as drugs. This method results in a system for controlled release of active ingredients and especially for controlled drug delivery. In accordance with the present invention, the tem controlled release ” encompasses all kinds of controlled release, including slow release, sustained and delayed release. Particularly, the present invention results in active ingredients, entrapped in or otherwise incorporated in or coupled to polymer carriers or polymeric devices, such as micelles, nanoparticles, microspheres and other types of polymer devices for controlled release; the active ingredients are covalently bonded to the polymer carriers or polymeric devices.Type: ApplicationFiled: September 17, 2009Publication date: September 8, 2011Applicant: UNIVERSITEIT UTRECHT HOLDING B.V.Inventors: Cristianne Johanna Ferdinand Rijcken, Wilhelmus Everhardus Hennink, Cornelis Franciscus Van Nostrum
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Publication number: 20100255098Abstract: The invention relates to hydrogel compositions, which can be applied as biodegradable materials and to the processes to prepare such hydrogels. The hydrogel of the present invention comprises a stereocomplex gel structure which is the result of the interaction of oligomerized monomers of one chirality with that of oligomerized monomers of the opposite chirality, both grafted to hydrophilic polymers. The grafts form an interaction which is different from a covalent chemical interaction and thus provide the gel with the required coherence.Type: ApplicationFiled: October 8, 2009Publication date: October 7, 2010Inventors: Wilhelmus Everhardus HENNINK, Cornelis Franciscus Van Nostrum, Silvia Johanna De Jong
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Patent number: 7776359Abstract: The invention relates to hydrogel compositions, which can be applied as biodegradable materials and to the processes to prepare such hydrogels. The hydrogel of the present invention comprises a stereocomplex gel structure which is the result of the interaction of oligomerized monomers of one chirality with that of oligomerized monomers of the opposite chirality, both grafted to hydrophilic polymers. The grafts form an interaction which is different from a covalent chemical interaction and thus provide the gel with the required coherence.Type: GrantFiled: February 21, 2000Date of Patent: August 17, 2010Assignee: Universiteit UtrechtInventors: Wilhelmus Everhardus Hennink, Cornelis Franciscus van Nostrum, Silvia Johanna de Jong