Patents by Inventor Wilhelmus Johannes Elisabeth Van Esch

Wilhelmus Johannes Elisabeth Van Esch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF DISEASES RELATED TO HEPATITIS B VIRUS
    Publication number: 20230242590
    Abstract: The invention provides novel immunogenic peptides derived from the X protein and polymerase protein of hepatitis B virus (HBV). The peptides contain epitopes that are well-conserved across multiple HBV variants and are derived from regions of proteins that are essential for viral replication. Moreover, the novel HBV antigens bind multiple HLA types and epitopes that elicit IFN? responses in PBMCs from HBV resolvers have been identified.
    Type: Application
    Filed: December 4, 2020
    Publication date: August 3, 2023
    Applicants: ISA Pharmaceuticals B.V., Erasmus University Medical Center Rotterdam
    Inventors: Sonja Ingrid Buschow, Monica Theodora Antonetta de Beijer, Miranda Bernardina Johanna Molenaar, Thomas Johannes Maria Beenakker, Wilhelmus Johannes Theodorus Alexander Krebber, Cornelis Johannes Maria Melief, Anna-Sophia Wiekmeijer, Peter van Rijn, Diahann Talia Satirah Ludovica Jansen, Wilhelmus Johannes Elisabeth van Esch
  • Cleavage and exchange of major histocompatibility complex ligands employing azobenzene-containing peptides
    Patent number: 10400024
    Abstract: In one aspect, the disclosure relates to major histocompatibility complex (MHC) molecules comprising a ligand in the peptide binding groove of the MHC molecule, whereby the ligand comprises an azobenzene (Abc), and at least two amino acid residues separated by the azo-group of the Abc, and wherein the amino acid residues are positioned to interact with the peptide binding groove of the MHC molecule. The disclosure also relates, among others, to means and methods for producing and using such MHC molecules, and the ligands therefor.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: September 3, 2019
    Assignee: SANQUIN REAGENTS B.V.
    Inventors: Gijsbert Marnix Grotenbreg, Steven Hendrik Leonard Verhelst, Ai Ling Joanna Choo, Sock Yue Thong, Jiawei Yap, Wilhelmus Johannes Elisabeth Van Esch
  • CLEAVAGE AND EXCHANGE OF MAJOR HISTOCOMPATIBILITY COMPLEX LIGANDS EMPLOYING AZOBENZENE-CONTAINING PEPTIDES
    Publication number: 20170101459
    Abstract: In one aspect, the disclosure relates to major histocompatibility complex (MHC) molecules comprising a ligand in the peptide binding groove of the MHC molecule, whereby the ligand comprises an azobenzene (Abc), and at least two amino acid residues separated by the azo-group of the Abc, and wherein the amino acid residues are positioned to interact with the peptide binding groove of the MHC molecule. The disclosure also relates, among others, to means and methods for producing and using such MHC molecules, and the ligands therefor.
    Type: Application
    Filed: June 5, 2015
    Publication date: April 13, 2017
    Inventors: Gijsbert Marnix Grotenbreg, Steven Hendrik Leonard Verhelst, Ai Ling Joanna Choo, Sock Yue Thong, Jiawei Yap, Wilhelmus Johannes Elisabeth Van Esch