Patents by Inventor Wilhelmus Theodorus Johannes Maria Christiaan Maria Christ HERMENS

Wilhelmus Theodorus Johannes Maria Christiaan Maria Christ HERMENS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optimization of expression of parvoviral rep and cap proteins in insect cells
    Patent number: 9260724
    Abstract: The present invention relates to the improved production of recombinant parvoviral virions in insect cells. In particular, the invention relates to an improved process for the production of recombinant parvoviral virions in insect cells, wherein the full/empty parvoviral virion ratio is increased. The invention also relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral Rep proteins that increase the productivity of parvoviral vectors.
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: February 16, 2016
    Assignee: UNIQURE IP B.V.
    Inventors: Andrew Christian Bakker, Wilhelmus Theodorus Johannes Maria Christiaan Maria Christ Hermens, Yvet Noordman
  • VECTORS WITH MODIFIED INITIATION CODON FOR THE TRANSLATION OF AAV-REP78 USEFUL FOR PRODUCTION OF AAV
    Publication number: 20150140639
    Abstract: The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e.g. adeno-associated viral) vectors in insect cells, to insect cells comprising such constructs and to methods wherein the cells are used to produce recombinant parvoviral virions. The insect cells preferably comprise a first nucleotide sequence encoding the parvoviral rep proteins whereby the initiation codon for translation of the parvoviral Rep78 protein is a suboptimal initiation codon that effects partial exon skipping upon expression in insect cells. The insect cell further comprises a second nucleotide sequence comprising at least one parvoviral (AAV) inverted terminal repeat (ITR) nucleotide sequence and a third nucleotide sequence comprising a sequences coding for the parvoviral capsid proteins.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 21, 2015
    Inventors: Wilhelmus Theodorus Johannes Maria Christiaan Maria Christ HERMENS, Saskia Jacoba Petronella HAAST, Dennis Johan BIESMANS, Andrew Christian BAKKER
  • OPTIMIZATION OF EXPRESSION OF PARVOVIRAL REP AND CAP PROTEINS IN INSECT CELLS
    Publication number: 20140127801
    Abstract: The present invention relates to the improved production of recombinant parvoviral virions in insect cells. In particular, the invention relates to an improved process for the production of recombinant parvoviral virions in insect cells, wherein the full/empty parvoviral virion ratio is increased. The invention also relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral Rep proteins that increase the productivity of parvoviral vectors.
    Type: Application
    Filed: January 8, 2014
    Publication date: May 8, 2014
    Applicant: uniQure IP B.V.
    Inventors: Andrew Christian BAKKER, Wilhelmus Theodorus Johannes Maria Christiaan Maria Christ HERMENS, Yvet NOORDMAN