Patents by Inventor Wilhelmus Zwaan

Wilhelmus Zwaan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of N-carboxy-t-leucine anhydride
    Patent number: 6476231
    Abstract: Process for the preparation of N-carboxy-t-leucine anhydride in which the corresponding N-carboxy-t-leucine is subjected to a cyclization with the aid of an acyl halogenide. Preferably, acetyl chloride is used as acyl halogenide. The N-carboxy-t-leucine anhydride obtained optionally is subsequently converted into a t-leucine-N-substituted amide with the aid of the corresponding amine. Preferably, methyl amine is chosen as the amine, and the reaction is carried out in a mixture of water and methanol as solvent.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: November 5, 2002
    Assignee: DSM N.V.
    Inventors: Robert P Hof, Wilhelmus Zwaan
  • Process for the preparation of N-carboxy-t-leucine anhydride
    Publication number: 20010041812
    Abstract: Process for the preparation of N-carboxy-t-leucine anhydride in which the corresponding N-carboxy-t-leucine is subjected to a cyclization with the aid of an acyl halogenide. Preferably, acetyl chloride is used as acyl halogenide.
    Type: Application
    Filed: May 11, 2001
    Publication date: November 15, 2001
    Applicant: DSM N.V.
    Inventors: Robert P. Hof, Wilhelmus Zwaan