Abstract: The invention discloses novel compounds of the general formula: ##STR1## and salts thereof, in which X stands for oxygen, sulphur, the group >NR.sub.7 or the group --CR.sub.8 R.sub.9 --;R.sub.1, r.sub.2, r.sub.3 and R.sub.4 represent hydrogen, hydroxy, halogen, alkyl (1-6 C), alkoxy (1-6 C), alkylthio (1-6 C) or trifluoromethyl;R.sub.5 and R.sub.6 represent hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or together in combination with the nitrogen atom a heterocyclic five- or six-membered ring;R.sub.7 stands for hydrogen or alkyl (1-4 C);R.sub.8 and R.sub.9 stand for hydrogen or methyl,n is the number 0, 1 or 2 andThe dotted line means an optional C--C bond, with valuable central nervous system (CNS) activities, especially antidepressant activity.

Abstract: The invention relates to compounds of the general formula I: ##STR1## or a salt thereof, in which A represents a pyridine ring or a halogen substituted pyridine ring,R.sub.1 represents hydrogen, alkyl (1-6 C), alkoxy (1-6 C), alkylthio (1-6 C), halogen, OH, SH or CF.sub.3R.sub.2 represents hydrogen or a lower alkyl or aralkyl group andn and m may each be 1, 2 or 3 with the proviso that the sum of m and n must be 2, 3 or 4, having CNS activity, a pronounced antihistamine activity and little or no antiserotonin activity.

Abstract: The invention discloses novel compounds of the general formula: ##STR1## and salts thereof, IN WHICH THE AMINO(ALKYL) MOIETY IS PRESENT AT POSITION 2 OR 3 AND IN WHICHX stands for oxygen, sulphur, the group >NR.sub.7 or the group --CR.sub.9 R.sub.9 --;R.sub.1, r.sub.2, r.sub.3 and R.sub.4 represent hydrogen, hydroxy, halogen, alkyl (1-6 C), alkoxy (1-6 C), alkylthio (1-6 C) or trifluoromethyl;R.sub.5 and R.sub.6 represent hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or together in combination with the nitrogen atom a heterocyclic five- or six-membered ring;R.sub.7 stands for hydrogen or alkyl (1-4 C);R.sub.8 and R.sub.9 stand for hydrogen or methyl and is the number 0, 1, 2 or 3,Having valuable central nervous system (CNS) activities, especially antidepressant activity.

Abstract: The invention is dealing with compounds of the general formula: ##STR1## as well as the pharmaceutically acceptable salts thereof, in which X represents oxygen, sulphur, the group >NR.sub.7 or the group --CR.sub.8 R.sub.9 --,R.sub.1, r.sub.2, r.sub.3 and R.sub.4 represent hydrogen, hydroxy, halogen, an alkyl, alkoxy or alkylthio group or a trifluoromethyl group,R.sub.5 and R.sub.6 represent hydrogen, an alkyl group or an aralkyl group,R.sub.7 represents hydrogen or alkyl (1-4 C),R.sub.8, r.sub.9 represent hydrogen or methyl, andQ represents hydrogen (2H) or oxygen,Having valuable antihistamine, sedative and antidepressive properties.

Abstract: The invention discloses novel compounds of the general formula: ##STR1## and salts thereof, in which the amino(alkyl) moiety is present at position 2 or 3 and in whichX stands for oxygen, sulphur, the group <NR.sub.7 or the group --CR.sub.8 R.sub.9 --;R.sub.1, r.sub.2, r.sub.3 and R.sub.4 represent hydrogen, hydroxy, halogen, alkyl (1-6 C), alkoxy (1-6 C), alkythio (1-6 C) or trifluoromethyl;R.sub.5 and R.sub.6 represent hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or together in combination with the nitrogen atom a heterocyclic five- or six-membered ring;R.sub.7 stands for hydrogen or alkyl (1-4 C);R.sub.8 and R.sub.9 stand for hydrogen or methyl andn is the number 0, 1, 2 or 3,Having valuable central nervous system (CNS) activities, especially antidepressant activity.

Abstract: The invention relates to antidepressive biologically active tetracyclic piperidino derivatives of the general formula: ##STR1## as well as the pharmaceutically acceptable salts and nitrogen oxides (N.sub.2) thereof, in which:R.sub.1 and R.sub.2 represent hydroxy, halogen, alkyl (1-6 C), alkoxy (1-6 C), alkylthio (1-6 C) or trifluoromethyl,R.sub.3 stands for hydrogen, alkyl (1-6 C) or aralkyl (7-10 C),r and r' stand for the number 0, 1 or 2,X represents oxygen, sulphur, the group >NR.sub.4 or methylene andR.sub.4 stands for hydrogen or alkyl (1-4 C).

Abstract: The invention discloses novel compounds of the general formula: ##SPC1##And salts thereof, in which the amino(alkyl) moiety is present at position 2 or 3 and in whichX stands for oxygen, sulphur, the group >NR.sub.7 or the group --CR.sub.8 R.sub. 9 --;R.sub.1, r.sub.2, r.sub.3 and R.sub.4 represent hydrogen, hydroxy, halogen, alkyl (1-6 C), alkoxy (1-6 C), alkylthio (1-6 C) or trifluoromethyl;R.sub.5 and R.sub.6 represent hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or together in combination with the nitrogen atom a heterocyclic five- or six-membered ring;R.sub.7 stands for hydrogen or alkyl (1-4 C);R.sub.8 and R.sub.9 stand for hydrogen or methyl andn is the number 0, 1, 2 or 3,Having valuable central nervous system (CNS) activities, especially antidepressant activity.

Abstract: The invention relates to novel imidazolidine derivatives of the general formula: ##SPC1##In whichr and s = 0-5,R.sub.1 and R.sub.2 = hydroxy, halogen, alkyl or alkoxy with 1-6 carbon atoms, acyloxy with 1-8 carbon atoms or a trifluoromethyl group, R.sub.3 = hydrogen, and alkyl group with 1-6 carbon atoms, an aryl group or an aralkyl group (7-9 C)as well as pharmaceutically acceptable salts thereof, having valuable anticholinergic and anticonvulsive activities.

Abstract: The invention discloses novel compounds of the general formula: ##SPC1##And salts thereof,In whichX stands for oxygen, sulphur, the group >NR.sub.7 or the group --CR.sub.8 R.sub.9 --;R.sub.1, r.sub.2, r.sub.3 and R.sub.4 represent hydrogen, hydroxy, halogen, alkyl (1-6 C), alkoxy (1-6 C), alkylthio (1-6 C) or trifluoromethyl;R.sub.5 and R.sub.6 represent hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or together in combination with the nitrogen atom a heterocyclic five- or six-membered ring;R.sub.7 stands for hydrogen or alkyl (1-4 C);R.sub.8 and R.sub.9 stands for hydrogen or methyl,n is the number 0, 1 or 2 andThe dotted line means an optional C-C bond,With valuable central nervous system (CNS) activites, especially antidepressant activity.The invention further discloses novel intermediates of the general formula: ##SPC2##As well as biologically active intermediates of the formula: ##SPC3##As well as salts and esters thereof.