Patents by Inventor Willem Karel Bleeker

Willem Karel Bleeker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FUSION OR LINKED PROTEINS WITH EXTENDED HALF LIFE
    Publication number: 20110045007
    Abstract: The present invention provides fusion proteins comprising a first molecule, and a second molecule which is a monovalent immunoglobulin or a fragment of a monovalent immunoglobulin with a long half-life when administered in vivo, methods of making such fusion proteins, pharmaceutical compositions comprising such fusion proteins, and uses thereof.
    Type: Application
    Filed: May 30, 2008
    Publication date: February 24, 2011
    Applicant: GENMAB A/S
    Inventors: Janine Schuurman, Tom Vink, Jan Van De Winkel, Aran Frank Labrljn, Paul Parren, Willem Karel Bleeker, FRank Beurskens, Patrick Van Berkel
  • NON-GLYCOSYLATED RECOMBINANT MONOVALENT ANTIBODIES
    Publication number: 20100325744
    Abstract: The present invention provides non-glycosylated monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies, pharmaceutical compositions comprising such antibodies, and uses of the monovalent antibodies.
    Type: Application
    Filed: May 30, 2008
    Publication date: December 23, 2010
    Applicant: GENMAB A/S
    Inventors: Janine Schuurman, Tom Vink, Jan Van De Winkel, Aran Frank Labrijn, Paul Parren, Willem Karel Bleeker, Patrick Van Berkel, Frank Beurskens
  • TRANSGENIC ANIMALS PRODUCING MONOVALENT HUMAN ANTIBODIES AND ANTIBODIES OBTAINABLE FROM THESE ANIMALS
    Publication number: 20100306867
    Abstract: The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.
    Type: Application
    Filed: May 30, 2008
    Publication date: December 2, 2010
    Applicant: GENMAB A/S
    Inventors: Janine Schuurman, Tom Vink, Jan Van De Winkel, Aran Frank Labrijn, Paul Parren, Willem Karel Bleeker, Frank Beurskens, Patrick Van Berkel
  • METHOD FOR EXTENDING THE HALF-LIFE OF EXOGENOUS OR ENDOGENOUS SOLUBLE MOLECULES
    Publication number: 20100291023
    Abstract: The present invention relates to methods for extending the in vivo half-life of an exogenous soluble therapeutic molecule administered to a subject, by administering to said subject the exogenous soluble molecule and a monovalent antibody that binds to the exogenous soluble molecule, as well as method for treating a disease or disorder associated with an insufficient level of an endogenous soluble molecule in a subject, by administering to said subject a monovalent antibody that binds to the endogenous soluble molecule.
    Type: Application
    Filed: May 30, 2008
    Publication date: November 18, 2010
    Applicant: GENMAB A/S
    Inventors: Janine Schuurman, Tom Vink, Jan Van de Winkel, Aran Frank Labrijn, Paul Parren, Frank Beurskens, Willem Karel Bleeker, Patrick Van Berkel
  • RECOMBINANT FUCOSE MODIFIED MONOVALENT HALF-ANTIBODIES OBTAINED BY MOLECULAR ENGINEERING
    Publication number: 20100255012
    Abstract: Glycosylated monovalent antibodies binding to selected antigens with a low or lacking fucose content, which are capable of inducing antibody dependent cellular cytotoxicity (ADCC) on cells expressing the selected antigens in the presence of effector cells, methods for producing the monovalent antibodies, pharmaceutical compositions comprising such monovalent antibodies and use thereof for different diagnostic and therapeutic applications.
    Type: Application
    Filed: May 30, 2008
    Publication date: October 7, 2010
    Applicant: GENMAB A/S
    Inventors: Janine Schuurman, Tom Vink, Jan Van De Winkel, Aran Frank Labrijn, Paul Parren, Willem Karel Bleeker, Frank Beurskens, Patrick Van Berkel
  • RECOMBINANT MONOVALENT ANTIBODIES AND METHODS FOR PRODUCTION THEREOF
    Publication number: 20090226421
    Abstract: The present invention provides monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies, pharmaceutical compositions comprising such antibodies, and uses of the monovalent antibodies.
    Type: Application
    Filed: November 28, 2006
    Publication date: September 10, 2009
    Applicant: GENMAB A/S
    Inventors: Paul Parren, Janine Schuurman, Tom Vink, Willem Karel Bleeker, Jan Van De Winkel, Patrick Van Berkel, Frank Beurskens
  • Hemoglobin composition and preparation thereof
    Patent number: 5646252
    Abstract: The described invention relates to an essentially stroma-free hemoglobin composition evidencing properties suitable for use as a universally applicable blood plasma expander and to a method for the preparation thereof. Typical, of these properties are desirable oxygen affinity values, desirable vascular retention time and substantial absence of toxic side effects. The described composition comprises human hemoglobin cross-linked intramolecularly through the beta-chains and polymerized with glutaraldehyde. Intramolecular cross-linking is typically effected with 2-nor-2-formylpyridoxal 5-phosphate or a bis-pyridoxal polyphosphate.
    Type: Grant
    Filed: October 16, 1995
    Date of Patent: July 8, 1997
    Assignee: Staat der Nederlanden, De Minister van Defensie, voor deze: Het Hoofd van de Afdeling Militair Geneeskundig Beleid
    Inventors: Wilhelmus Antonius Berbers, Petrus Theodorus Maria Biessels, Willem Karel Bleeker, Joachim Cornelis Bakker