Abstract: The invention relates to a tap (8) for fluids, in particular carbonated liquids, such as beer or soft drink, comprising a tap body (14), a valve (9) removably accommodated in the tap body (14), and a handle (20) for opening and closing the tap (8). The valve (9) comprises a first part (22) coupled or to be coupled to the tap body (14) and a second part (27) connected to the first part (22) and operatively coupled or to be coupled to the handle (20), the first and second parts (22, 27) being rotatable and/or translatable relative to each other between at least an open position and a closed position. A protective cap (34) prevents the valve (9) from being closed. The cap (34) is removable only after installation of the valve (9) in the tap body (14).

Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1): wherein the symbols have the meanings given in the specification, and tautomers, stereoisomers and N-oxides thereof, as well as pharmacologically acceptable salts, hydrates and solvates of said compounds of formula (1) and its tautomers, stereoisomers and N-oxides.

Abstract: The invention relates to a group of novel benzimidazolone and quinazolinone derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these imidazolone and quinazolinone derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1): wherein the symbols have the meanings as given in the description.

Abstract: The invention relates to a tap (8) for fluids, in particular carbonated liquids, such as beer or soft drink, comprising a tap body (14), a valve (9) removably accommodated in the tap body (14), and a handle (20) for opening and closing the tap (8). The valve (9) comprises a first part (22) coupled or to be coupled to the tap body (14) and a second part (27) connected to the first part (22) and operatively coupled or to be coupled to the handle (20), the first and second parts (22, 27) being rotatable and/or translatable relative to each other between at least an open position and a closed position. A protective cap (34) prevents the valve (9) from being closed. The cap (34) is removable only after installation of the valve (9) in the tap body (14).

Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1): wherein the symbols have the meanings given in the specification.

Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1): wherein the symbols have the meanings given in the specification. and tautomers, stereoisomers and N-oxides thereof, as well as pharmacologically acceptable salts, hydrates and solvates of said compounds of formula (1) and its tautomers, stereoisomers and N-oxides.

Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1): wherein the symbols have the meanings given in the specification.

Abstract: The invention relates to a group of novel aryloxyethylamine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1): Z-T-Ar??(1) wherein: Z is a fragment of the general formula (2): and wherein the other symbols have the meanings given in the specification, and tautomers, stereoisomers and N-oxides thereof, as well as pharmacologically acceptable salts, hydrates and solvates of said compounds of formula (1) and its tautomers, stereoisomers and N-oxides.

Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1): wherein the symbols have the meanings given in the specification. and tautomers, stereoisomers and N-oxides thereof, as well as pharmacologically acceptable salts, hydrates and solvates of said compounds of formula (1) and its tautomers, stereoisomers and N-oxides.

Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1): wherein the symbols have the meanings given in the specification, and tautomers, stereoisomers and N-oxides thereof, as well as pharmacologically acceptable salts, hydrates and solvates of said compounds of formula (1) and its tautomers, stereoisomers and N-oxides.

Abstract: The invention relates to a group of novel benzimidazolone and quinazolinone derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these imidazolone and quinazolinone derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1): wherein the symbols have the meanings as given in the description.

Abstract: The invention relates to a closure for a container to be pressurized, comprising a housing to be fixed to the container, in which a passage is present, whilst a seat is arranged in said passage, which seat is intended to mate with a closing element, which is urged in the direction of the seat by means of a coil spring surrounding said closing element, said the coil spring being confined between a part of the closing element and a few spaced-apart projections formed in one piece with the housing, which are connected to the remaining part of the housing by means of a few spaced-apart arms, said coil spring and said projections being capable of resilient deformation relative to each other, in such a manner that the spring can be moved past the projections in its position of use.

Abstract: The invention relates to a closure for a container to be pressurised, comprising a housing to be fixed to the container, in which a passage is present, whilst a seat is arranged in said passage, which seat is intended to mate with a closing element, which is urged in the direction of the seat by means of a coil spring surrounding said closing element, said the coil spring being confined between a part of the closing element and a few spaced-apart projections formed in one piece with the housing, which are connected to the remaining part of the housing by means of a few spaced-apart arms, said coil spring and said projections being capable of resilient deformation relative to each other, in such a manner that the spring can be moved past the projections in its position of use.

Abstract: A valve for a keg of beer comprises a neck ring to be secured to the container and an inner part formed with a valve member, which fits an opening of the neck ring. A locking mechanism functions to lock the inner part in the neck ring, and a sealing ring forms a seal between the inner part and the neck ring at the location of opposite seat portions in the neck ring and the inner part. The inner part and the neck ring are provided with mutually cooperating coupling mechanisms, which, after the locking mechanisms have been released, provide for the removal of the inner part from the neck ring in two steps, wherein pressure relief takes place in the first step via at least one pressure relief opening. The pressure relief opening is formed through the wall of the neck ring, at a location a small distance above the seat portion in the neck ring, so as to effect a reliable pressure relief.