Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl,Ar is phenyl, 2-pyridyl, 6-methyl-2-pyridyl, 2-quinolyl, 1-methyl-benzimidazol-2-yl, 2-pyrazinyl or 3-methyl-isoxazol-5-yl, andR.sub.2 is dimethylamino, monomethylamino or morpholino,Or a non-toxic, pharmaceutically acceptable acid addition salt thereof; and a method of using the same as antiarrhythmics.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl or phenyl,R.sub.2 is hydrogen, chlorine or methoxy,R.sub.3 is hydrogen or methoxy,R.sub.2 and R.sub.3, together with each other, are methylenedioxy or ethylenedioxy,R.sub.4 and R.sub.5 are each hydrogen or lower alkyl,R.sub.6 is hydrogen or lower alkoxy.R.sub.7 is lower alkoxy,R.sub.6 and R.sub.7, together with each other, are methylenedioxy or ethylenedioxy, andn is 2 or 3,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful for slowing the heart rate.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl or phenyl,R.sub.2 is hydrogen, chlorine or methoxy,R.sub.3 is hydrogen or methoxy,R.sub.2 and R.sub.3, together with each other, are methylenedioxy or ethylenedioxy,R.sub.4 and R.sub.5 are each hydrogen or lower alkyl,R.sub.6 is hydrogen or lower alkoxy,R.sub.7 is lower alkoxy,R.sub.6 and R.sub.7, together with each other, are methylenedioxy or ethylenedioxy,X is carbonyl or sulfonyl, andn is 2 or 3,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful for slowing the heart rate.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, trifluoromethyl, alkyl of 1 to 5 carbon atoms, mercapto, lower alkyl-mercapto, phenyl, fluoro-phenyl, tolyl, hydroxy-phenyl, methylmercapto-phenyl, methylsulfinyl-phenyl, methylsulfonyl-phenyl, dimethylamino-phenyl, or mono-, di- or tri-methoxy-substituted phenyl;A is hydrogen or, together with B, a double bond,B is hydrogen, alkyl of 1 to 3 carbon atoms or, together with A, a double bond;C is, together with R.sub.2, a double bond, or, together with R.sub.3, oxygen;R.sub.2 is hydrogen, alkyl of 1 to 3 carbon atoms or, together with C, a double bond; andR.sub.3 is chlorine, methylamino, morpholino, 4-methylpiperazino or, when R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms, together with C, oxygen;And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as hypotensives, antithrombotics and cardiotonics.

Abstract: Compounds of the isomeric formulas ##SPC1##WhereinR.sub.1 is alkoxy of 1 to 4 carbon atoms, allyloxy, benzyloxy, methoxy-ethoxy, methylthio, methylsulfinyl, methylsulfonyl or methylsulfinylethoxy,R.sub.2 is hydrogen, hydroxyl, methyl, methoxy, ethoxy, fluorine, chlorine, (alkyl of 1 to 4 carbon atoms)-thio, (alkyl of 1 to 4 carbon atoms)-sulfinyl, (alkyl of 1 to 4 carbon atoms)-sulfonyl, dimethylamino or Z-A-O-whereA is alkylene of 2 to 3 carbon atoms, andZ is chlorine, hydroxyl, methylthio, ethylthio, methylsulfinyl; ethylsulfinyl, methylsulfonyl, ethylsulfonyl, methylamino, dimethylamino, diethylamino, phenethylamino, N-methyl-phenethylamino or N-methyl-dimethoxyphenethylamino,R.sub.3 is hydrogen or methoxy,Or any two of R.sub.1, R.sub.2 and R.sub.3 together are methylenedioxy, andR.sub.5 is hydrogen, chlorine or methyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as cardiotonics, anticoagulants and for altering the blood pressure.

Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##SPC1##Wherein R is cyano or carbalkoxy of 2 to 4 carbon atoms; and a method of using the same as cardiotonics.