Patents by Inventor Willi K. Born

Willi K. Born has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD TO INHIBIT AIRWAY HYPERRESPONSIVENESS USING AEROSOLIZED T CELL RECEPTOR ANTIBODIES
    Publication number: 20120128759
    Abstract: Disclosed is a method to reduce airway hyperresponsivesness in an animal by the direct delivery to the lungs of aerosolized antibodies against T cell receptors. The method is particularly useful for treating airway hyperresponsiveness associated with allergic inflammation, is effective at extremely low doses of antibody, and does not have a substantial effect on the peripheral immune system.
    Type: Application
    Filed: October 14, 2011
    Publication date: May 24, 2012
    Applicant: NATIONAL JEWISH HEALTH
    Inventors: Michael F. Lahn, Willi K. Born, Arihiko Kanehiro, Erwin Gelfand
  • Method to inhibit airway hyperresponsiveness using aerosolized T cell receptor antibodies
    Patent number: 8178098
    Abstract: Disclosed is a method to reduce airway hyperresponsivesness in an animal by the direct delivery to the lungs of aerosolized antibodies against T cell receptors. The method is particularly useful for treating airway hyperresponsiveness associated with allergic inflammation, is effective at extremely low doses of antibody, and does not have a substantial effect on the peripheral immune system.
    Type: Grant
    Filed: April 3, 2001
    Date of Patent: May 15, 2012
    Assignee: National Jewish Health
    Inventors: Michael F. Lahn, Willi K. Born, Arihiko Kanehiro, Erwin Gelfand
  • Modulation of Gamma-Delta T Cells to Regulate Airway Hyperresponsiveness
    Publication number: 20100272739
    Abstract: Disclosed is a method for regulation of airway hyperresponsiveness by modulating the action of ?? T cells in a patient. Also disclosed are methods for identifying compounds that regulate airway hyperresponsiveness by modulating ?? T cell action.
    Type: Application
    Filed: July 21, 2009
    Publication date: October 28, 2010
    Applicant: NATIONAL JEWISH MEDICAL AND RESEARCH CENTER
    Inventors: Erwin Gelfand, Willi K. Born, Michael F. Lahn, Arihiko Kanehiro
  • Modulation of gamma delta T cells to regulate airway hyperresponsiveness
    Patent number: 7582300
    Abstract: Disclosed is a method for regulation of airway hyperresponsiveness by modulating the action of ?? T cells in a patient. Also disclosed are methods for identifying compounds that regulate airway hyperresponsiveness by modulating ?? T cell action.
    Type: Grant
    Filed: March 24, 2004
    Date of Patent: September 1, 2009
    Assignee: National Jewish Health
    Inventors: Erwin Gelfand, Willi K. Born, Michael F. Lahn, Arihiko Kanehiro
  • AGENTS AND METHODS FOR INHIBITION OF AIRWAY HYPERRESPONSIVENESS
    Publication number: 20090028849
    Abstract: The present invention provides methods and compositions for inhibition of Airway Hyperresponsiveness (“AHR”) by deleting, inactivating or inhibiting a subset of innate ?? T cells, alone or in conjunction with the inhibition of Natural Killer T (“NKT”) cells. The methods comprise selective leukophoresis to remove the ?? T cells from the individual's blood or administration of an agent that selectively targets and inhibits or inactivates the ?? T cells. The methods of the present invention can be used to treat AHR in a variety of different ailments, including allergen-induced conditions or respiratory conditions and diseases.
    Type: Application
    Filed: July 24, 2008
    Publication date: January 29, 2009
    Inventors: Rebecca L. O'Brien, Willi K. Born, Niyun Jin, Christina L. Roark
  • Gamma Delta T Cells and Methods of Treatment of Interleukin-17 Related Conditions
    Publication number: 20080248025
    Abstract: This invention generally relates to methods to treat conditions and diseases associated with interleukin-17 (IL-17) production. The invention also relates to methods of inhibiting ?? T cells, and particularly, a subset of ?? T cells that produce IL-17.
    Type: Application
    Filed: March 21, 2008
    Publication date: October 9, 2008
    Applicant: NATIONAL JEWISH MEDICAL AND RESEARCH CENTER
    Inventors: Christina Roark, Rebecca L. O'Brien, Willi K. Born
  • Modulation of &ggr;&dgr; T cells to regulate airway hyperresponsiveness
    Patent number: 6737398
    Abstract: Disclosed is a method for regulation of airway hyperresponsiveness by modulating the action of &ggr;&dgr; T cells in a patient. Also disclosed are methods for identifying compounds hyperresponsiveness by modulating &ggr;&dgr; T cell action.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: May 18, 2004
    Assignee: National Jewish Medical and Research Center
    Inventors: Erwin Gelfand, Willi K. Born, Michael F. Lahn, Arihiko Kanehiro
  • Use of soluble gammadelta T cell receptors for regulating T cell function
    Publication number: 20030175212
    Abstract: Disclosed is a method of using soluble &ggr;&dgr; T cell receptors to regulate a &ggr;&dgr; T cell-mediated immune response in a mammal.
    Type: Application
    Filed: January 10, 2003
    Publication date: September 18, 2003
    Inventors: Rebecca L. O'Brien, Willi K. Born, Christina L. Roark, M. Kemal Aydintug
  • Method to inhibit airway hyperresponsiveness using aerosolized T cell receptor antibodies
    Publication number: 20020172677
    Abstract: Disclosed is a method to reduce airway hyperresponsivesness in an animal by the direct delivery to the lungs of aerosolized antibodies against T cell receptors. The method is particularly useful for treating airway hyperresponsiveness associated with allergic inflammation, is effective at extremely low doses of antibody, and does not have a substantial effect on the peripheral immune system.
    Type: Application
    Filed: April 3, 2001
    Publication date: November 21, 2002
    Inventors: Michael F. Lahn, Willi K. Born, Arihiko Kanehiro, Erwin Gelfand