Abstract: Methods utilizing vaccinia virus with mutations in E3L to infect and cause lysis of cancer cells with less than normal protein levels of RIP3 and/or DAI. Further, the disclosed vaccinia viruses with mutations in E3L cannot replicate well in cells with normal expression or upregulation of RIP3, DAI, and/or MLKL.

Abstract: Methods utilizing vaccinia virus with mutations in E3L to infect and cause lysis of cancer cells with less than normal protein levels of RIP3 and/or DAI. Further, the disclosed vaccinia viruses with mutations in E3L cannot replicate well in cells with normal expression or upregulation of RIP3, DAI, and/or MLKL.

Abstract: The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

Abstract: The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

Abstract: The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

Abstract: A dual mass flywheel and dual clutch module assembly includes a connector plate and a drive plate. The connector plate is fastened to a center plate of the dual clutch module and has a plurality of castellation tabs disposed on an inner periphery of the connector plate. The drive plate drivingly connected to a flywheel member of the dual mass flywheel and includes a plurality of castellation tabs disposed on an inner periphery of the drive plate. The plurality of castellation tabs of the connector plate are interleaved with the plurality of castellation tabs of the drive plate.

Abstract: A dual mass flywheel and dual clutch module assembly includes a connector plate and a drive plate. The connector plate is fastened to a center plate of the dual clutch module and has a plurality of castellation tabs disposed on an inner periphery of the connector plate. The drive plate drivingly connected to a flywheel member of the dual mass flywheel and includes a plurality of castellation tabs disposed on an inner periphery of the drive plate. The plurality of castellation tabs of the connector plate are interleaved with the plurality of castellation tabs of the drive plate.

Abstract: A torque transmitting device for use in an automotive transmission is provided. The device includes an inner annular race and an outer annular race disposed concentrically around the inner annular race. A selector plate is disposed adjacent to the inner and outer annular races, the selector plate being movable with respect to the inner and outer races. Multiple control elements are pivotally connected to the selector plate. The control elements are disposed between the inner and outer races. A plurality of sprag elements is disposed between the inner and outer races. Each sprag element is disposed adjacent to a control element.

Abstract: A transmission includes a housing defining a sealed interior and an input hub rotatably coupled to the housing. A gear set is disposed within the housing and configured for receiving a torque from an engine. The transmission further includes an isolator assembly and a bypass clutch, each disposed within the sealed interior of the housing. The isolator assembly is configured for selectively damping drivetrain inertia and/or vibration. The bypass clutch selectively engages and disengages the isolator assembly.

Abstract: The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

Abstract: A torque transmitting device for use in an automotive transmission is provided. The device includes an inner annular race and an outer annular race disposed concentrically around the inner annular race. A selector plate is disposed adjacent to the inner and outer annular races, the selector plate being movable with respect to the inner and outer races. Multiple control elements are pivotally connected to the selector plate. The control elements are disposed between the inner and outer races. A plurality of sprag elements is disposed between the inner and outer races. Each sprag element is disposed adjacent to a control element.

Abstract: A gear retention assembly for retaining a gear that has a plurality of gear outer splines includes a gear housing and a retaining ring. The gear housing has a first end, a second end, and a plurality of inner splines each including a ramp portion. The second end of the gear housing includes an annular continuous rolled lip, where the continuous rolled lip and the ramp portions of the plurality of inner splines define a groove. The plurality of inner splines engage with the gear outer splines of the gear to transmit torque between the gear and the gear housing. The retaining ring is disposed in the groove and axially retains the gear. The rolled lip axially retains the retaining ring.

Abstract: A retaining ring is characterized by a variable effective inner diameter and a variable effective outer diameter to axially retain a first member with respect to a second member.

Abstract: A gear retention assembly for retaining a gear that has a plurality of gear outer splines includes a gear housing and a retaining ring. The gear housing has a first end, a second end, and a plurality of inner splines each including a ramp portion. The second end of the gear housing includes an annular continuous rolled lip, where the continuous rolled lip and the ramp portions of the plurality of inner splines define a groove. The plurality of inner splines engage with the gear outer splines of the gear to transmit torque between the gear and the gear housing. The retaining ring is disposed in the groove and axially retains the gear. The rolled lip axially retains the retaining ring.

Abstract: A transmission includes a housing defining a sealed interior and an input hub rotatably coupled to the housing. A gear set is disposed within the housing and configured for receiving a torque from an engine. The transmission further includes an isolator assembly and a bypass clutch, each disposed within the sealed interior of the housing. The isolator assembly is configured for selectively damping drivetrain inertia and/or vibration. The bypass clutch selectively engages and disengages the isolator assembly.

Abstract: A gum wrapper having two sheets of paper laminated with PLA resin material therebetween for packaging a plurality of wrapped, individual sticks of chewing gum.

Abstract: A box for wrapped reams of copier, printer, or computer papers that provides more strength and protection for the reams inside.

Abstract: Ream wraps comprising PLA.

Abstract: A method and apparatus for detecting patches or areas of relatively high gloss on a moving web, and thereby associated wrinkles or other defects, and signalling the presence thereof comprises an analog and/or digital optical reflectivity sensor for sensing gloss on the surface of the moving web, a web marking device adjacent the edge of the moving web for marking the edge of the web with a dye, and a microcomputer for receiving the output signal from the sensor(s) and for controlling the operation of the marking device. The apparatus may also include a warning device such as a light or horn. The apparatus and method have particular applicability in association with paper web re-reeling equipment.

Abstract: A friction torque transmitting mechanism has a plurality of reaction plates interleaved with a plurality of friction drive plates. The reaction plates are brought into frictional contact with the drive plates by a fluid operated piston, such that a transfer of torque can be conducted through the frictional engagement of the plates. The reaction plates have a reaction portion disposed in a slot in a housing. One of the reaction plates has an axially extending reaction tab positioned between the reaction portions of the remaining plates and the sidewall of the slot. The reaction forces on the reaction portions are transmitted to the sidewall through the reaction tab.