Patents by Inventor William A. Bolhofer

William A. Bolhofer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amino-phenyl-thiadiazoledioxides as gastric secretion inhibitors
    Patent number: 4567191
    Abstract: Novel amino-phenyl-thiadiazoledioxides and related compounds and processes for preparing such compounds are disclosed. The compounds are useful for suppressing gastric acid secretions in mammals.
    Type: Grant
    Filed: June 7, 1983
    Date of Patent: January 28, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Adolph Pietruszkiewicz, William A. Bolhofer, William C. Lumma, Jr.
  • Aminoalkyl pyridine derivatives
    Patent number: 4490533
    Abstract: There are disclosed novel compounds described as aminoalkyl pyridine derivatives in which the aminoalkyl pyridine is connected to a guanidine moiety or a functional equivalent thereof, either directly or through a linear connecting group. Processes for the preparation of such compounds are also disclosed. The compounds are useful for the suppression of gastirc acid secretions in mammals and compositions for such uses are also disclosed.
    Type: Grant
    Filed: September 29, 1981
    Date of Patent: December 25, 1984
    Assignee: Merck & Co., Inc.
    Inventors: William A. Bolhofer, Jacob M. Hoffman
  • Substituted pyridopyrimidines as gastric secretion inhibitors
    Patent number: 4420615
    Abstract: There are disclosed novel substituted pyridopyrimidine compounds and processes for preparing such compounds. These compounds are useful as gastric secretion inhibitors in mammals.
    Type: Grant
    Filed: August 24, 1981
    Date of Patent: December 13, 1983
    Assignee: Merck & Co., Inc.
    Inventors: William A. Bolhofer, Edward J. Cragoe, Jacob M. Hoffman, Jr
  • Suppression of gastric acid secretion using pyrimidylcarbamates
    Patent number: 4415575
    Abstract: Heterocyclic carbamates are disclosed which have potent gastric secretion inhibitory properties. The heterocyclic substituent is a pyridyl group or a 6-membered heterocycle with two nitrogen heteroatoms, which may be optionally substituted. Further substituents on the carbamate nitrogen and oxygen atoms are also disclosed. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
    Type: Grant
    Filed: February 5, 1982
    Date of Patent: November 15, 1983
    Assignee: Merck & Co., Inc.
    Inventors: William A. Bolhofer, John D. Prugh
  • Imidazole or imidazoline substituted ureas
    Patent number: 4293703
    Abstract: Organic chemical compounds based upon the urea molecule are disclosed which have potent gastric secretion inhibitory properties. The urea is substituted with a heterocyclic ring which may be substituted with one or more loweralkyl groups. The urea is also substituted with loweralkyl and a lower-alkylamino loweralkyl group. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
    Type: Grant
    Filed: July 7, 1980
    Date of Patent: October 6, 1981
    Assignee: Merck & Co., Inc.
    Inventor: William A. Bolhofer
  • Substituted ureas and processes for their preparation
    Patent number: 4241072
    Abstract: Organic chemical compounds based upon the urea molecule are disclosed which have potent gastric secretion inhibitory properties. The urea is substituted with a heterocyclic ring which may be substituted with one or more loweralkyl groups. The urea is also substituted with loweralkyl and a lower-alkylamino loweralkyl group. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
    Type: Grant
    Filed: January 18, 1979
    Date of Patent: December 23, 1980
    Assignee: Merck & Co., Inc.
    Inventor: William A. Bolhofer
  • Substituted naphthyridinones and processes for their preparations
    Patent number: 4229456
    Abstract: Organic chemical compounds based upon the naphthyridine molecule are disclosed which have potent gastric secretion inhibitory properties. The naphthyridinone is substituted with a substituted amino alkyl group at the 1-position, and variously substituted at the remaining positions. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
    Type: Grant
    Filed: October 23, 1978
    Date of Patent: October 21, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William A. Bolhofer, Edward J. Cragoe, Jr., Jacob M. Hoffman, Jr.
  • Heterocyclic carbamates
    Patent number: 4226871
    Abstract: Heterocyclic carbamates are disclosed which have potent gastric secretion inhibitory properties. The heterocyclic substituent is a pyridyl group or a 6-membered heterocycle with two nitrogen heteroatoms, which may be optionally substituted. Further substituents on the carbamate nitrogen and oxygen atoms are also disclosed. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
    Type: Grant
    Filed: March 13, 1979
    Date of Patent: October 7, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William A. Bolhofer, John D. Prugh
  • Cyclic imidazole cyanoguanidines
    Patent number: 4220654
    Abstract: There are disclosed novel compounds described as imidazole cyanoguanidines in which the imidazole moiety is connected to the cyanoguanidine moiety through a cyclic group which may optionally contain one or two alkylene linkages. The cyclic groups may be phenyl, cyclohexyl, thienyl and the like. Processes for the preparation of such compounds are also disclosed. The compounds are useful for the suppression of gastric acid secretion in mammals, and compositions for such uses are also disclosed.
    Type: Grant
    Filed: June 4, 1979
    Date of Patent: September 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William A. Bolhofer, Edward J. Cragoe, Jr., Jacob M. Hoffman, Jr.
  • Pyrazine substituted ureas
    Patent number: 4215121
    Abstract: Organic chemical compounds based upon the urea molecule are disclosed which have potent gastric secretion inhibitory properties. The urea is substituted with a 6 membered heterocyclic substituent containing 2 or 3 heteroatoms, and also with a substituted amino alkyl group. Further substitution is also possible. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
    Type: Grant
    Filed: November 8, 1978
    Date of Patent: July 29, 1980
    Assignee: Merck & Co., Inc.
    Inventor: William A. Bolhofer
  • Pyridinyl ureas and pharmaceutical use
    Patent number: 4203988
    Abstract: Compounds of the formula ##STR1## have been found to inhibit gastric secretion in mammalian species.
    Type: Grant
    Filed: September 18, 1978
    Date of Patent: May 20, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William A. Bolhofer, Edward J. Cragoe, Jr., Jacob M. Hoffman, Jr.
  • N-pyrimidinyl-N-dialkylaminoalkyl ureas
    Patent number: 4144338
    Abstract: Organic chemical compounds based upon the urea molecule are disclosed which have potent gastric secretion inhibitory properties. The urea is substituted with a 6 membered heterocyclic substituent containing 2 or 3 heteroatoms, and also with a substituted amino alkyl group. Further substitution is also possible. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: March 13, 1979
    Assignee: Merck & Co., Inc.
    Inventor: William A. Bolhofer
  • Substituted naphthyridinones
    Patent number: 4133885
    Abstract: Organic chemical compounds based upon the naphthyridine molecule are disclosed which have potent gastric secretion inhibitory properties. The naphthyridinone is substituted with a substituted amino alkyl group at the 1-position, and variously substituted at the remaining positions. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
    Type: Grant
    Filed: July 18, 1977
    Date of Patent: January 9, 1979
    Assignee: Merck & Co., Inc.
    Inventors: William A. Bolhofer, Edward J. Cragoe, Jr., Jacob M. Hoffman, Jr.
  • N-(Sulfo-lower alkyl) amides of (3-trifluoromethylphenoxy) (4-chlorophenyl)acetic acid
    Patent number: 4055592
    Abstract: N-(Sulfo-lower alkyl)amides of (3-trifluoromethylphenoxy)-(4-chlorophenyl)acetic acid which are useful in the treatment of atherosclerosis. The N-(sulfo-lower alkyl)amides of (3-trifluoromethylphenoxy) (4-chlorophenyl)-acetic acid are prepared by reacting a (3-trifluoromethylphenoxy) (4-chlorophenyl)acetyl halide with an amino-lower alkanesulfonic acid.
    Type: Grant
    Filed: February 13, 1976
    Date of Patent: October 25, 1977
    Assignee: Merck & Co., Inc.
    Inventor: William A. Bolhofer
  • 2-[.alpha.-(3-Trifluoromethylphenoxyl)-4-chlorobenzyl]oxazole and methods for preparing the same
    Patent number: 3953465
    Abstract: [.alpha.-(3-Trifluoromethylphenoxy)-4-chlorobenzyl heterocycles which are prepared by the cyclization of an appropriately substituted [.alpha.(3-trifluoromethylphenoxy)-4-chlorobenzyl]compound. The products reduce the concentration of cholesterol, trigylcerides and other lipids in blood serum and are therefore useful in the treatment of atherosclerosis.
    Type: Grant
    Filed: October 26, 1973
    Date of Patent: April 27, 1976
    Assignee: Merck & Co., Inc.
    Inventor: William A. Bolhofer