Abstract: Provided are FRET-based biosensor constructs, and multiplexed platforms or arrays of these biosensor constructs useful for screening candidate drug molecules for efficacy and/or specificity of drug activity. Optionally the biosensor constructs may be located on an inner membrane within a cell or engineered to be located on the cell's surface. The cells or cell lines displaying the biosensors on a cell surface may be arranged as an array of cells for high throughput evaluation of the efficacy and/or specificity of drug candidates, such as a library of candidate drug compounds.

Abstract: A hydrophone having a hollow interior with signal electrodes on the interior surface and an electrically conducting coating over the entire outside surface. Signal leads are connected to the inside electrodes and the outside electrically conducting surface is connected to a point of ground potential to form an effective electromagnetic interference shield.