Abstract: The present invention provides stable pharmaceutical compositions of pegylated carfilzomib compounds, methods for preparing the compositions, and uses of the compositions for treating cancer, including hematologic malignancies such as multiple myeloma. The compositions can be stored in frozen form or lyophilized to dry solid form.

Abstract: The present invention provides stable pharmaceutical compositions of pegylated carfilzomib compounds, methods for preparing the compositions, and uses of the compositions for treating cancer, including hematologic malignancies such as multiple myeloma. The compositions can be stored in frozen form or lyophilized to dry solid form.

Abstract: The invention relates to methods for preparing stable buffered and buffer-free protein compositions. The invention also relates to methods of purifying proteins from one or more impurities.

Abstract: The present invention provides stable pharmaceutical compositions of pegylated carfilzomib compounds, methods for preparing the compositions, and uses of the compositions for treating cancer, including hematologic malignancies such as multiple myeloma. The compositions can be stored in frozen form or lyophilized to dry solid form.

Abstract: A technique for uniformity tuning in an ion implanter system is disclosed. In one particular exemplary embodiment, the technique may be realized as a method for ion beam uniformity tuning. The method may comprise generating an ion beam in an ion implanter system. The method may also comprise tuning one or more beam-line elements in the ion implanter system to reduce changes in a beam spot of the ion beam when the ion beam is scanned along a beam path. The method may further comprise adjusting a velocity profile for scanning the ion beam along the beam path such that the ion beam produces a substantially uniform ion beam profile along the beam path.

Abstract: To address the requirements described above, one or more embodiments of the invention provide a method, apparatus, and article of manufacture for a project hosting service that a user can access with a web browser. With it, a user can communicate and collaborate with the members of a design team or construction project. Embodiments of the invention let a user share CAD drawing files (DWG DWF, etc.), document files, or any other type of file. A user can add comments or reply to discussion threads about the file or other aspects of the project. A user can view or download files from anywhere in the world to work on them, while locking the file to prevent others from overwriting the file. When the user is done, the file can be uploaded and unlocked while simultaneously notifying other Project members of the change by e-mail.

Abstract: A method of identifying or authenticating a product by providing an analog identification indicium including a randomized pattern of identification features on a first part of the product wherein one or more attributes of the randomized pattern of identification features correspond to an item identifier. A digital identification record is provided on a second part of the product including an encoded digital version of the item identifier, the first and second parts being separable when the product is used. The randomized pattern of identification features of the analog identification indicium is read and decoded to generate an item identifier and the digital identification record is read and decoded to generate an item identifier. The product is deemed authentic if the item identifier from the analog identification indicium substantially matches the item identifier from the digital identification record.

Abstract: An authentication-enabled indicium contains authentication information in a digital recording medium. The information may be a digital signature that verifies the manufacturer's data and/or an analog signature. The analog signature is generated by placing a randomized pattern on a product package or label and encoding information about the randomized pattern in the digital recording medium for verification. The randomized pattern may be made up of color-shifting features imbedded in the label that are visible when illuminated with UV or infrared light. Characteristics of the reflected light when the features are illuminated is used to generate an analog signature that is encoded in the recording medium. During processing the features are illuminated and a new analog signature is determined for comparison with the signature recorded in the digital recording medium.

Abstract: Provided is a window cover system designed to eliminate the problems related to windows that do not provide a proper barrier to the outside, nor a capable retainment system for the inside climate. The window cover system includes a flange and retainer system that is easily attached to a window casing by means of screws, and a snap on cover. The cover can be comprised of plastic, tinted or colored, or made of a screen-type material. The window cover system of the present invention may be installed by one individual, quickly, efficiently, and at a low cost.

Abstract: A handy computer accessory provides a mouse pad, which is cut out to provide an opening, and a paper pad in the opening. The paper pad consists of a stack of repositionable pressure sensitive adhesive sheets. When needed, the paper pad is visually and manually accessible to a computer operator. Graphics on the mouse pad and paper pad are functional and/or aesthetic. A used paper pad may be replaced easily by removing any residual backing and pressing a replacement paper pad into the opening in the mouse pad.

Abstract: A handy computer accessory provides a mouse pad, which is cut out to provide an opening, and a paper pad in the opening. The paper pad consists of a stack of repositionable pressure sensitive adhesive sheets. When needed, the paper pad is visually and manually accessible to a computer operator. Graphics on the mouse pad and paper pad are functional and/or aesthetic. A used paper pad may be replaced easily by removing any residual backing and pressing a replacement paper pad into the opening in the mouse pad.

Abstract: A method of improving the endogenous production of prostaglandins by a mammal is disclosed which comprises administering to the mammal an effective amount of certain 1-pyridylalkyl-3-phenylthioureas. Disclosed also are novel substituted 1-pyridylalkyl-3-phenylthioureas and therapeutic compositions thereof which are useful in carrying out the method of the invention.Disclosed also are methods of treating mammals for clinical conditions responsive to prostaglandins, such as for example, male infertility, epidermal injuries, atonic uterine bleeding, thromboembolic disease and like clinical conditions.

Abstract: A method of improving the endogenous production of prostaglandins by a mammal is disclosed, which comprises administering to the mammal an effective amount of certain 1-pyridylalkyl-3-phenylureas. Disclosed also are novel substituted 1-pyridylalkyl-3-phenylureas and therapeutic compositions thereof which are useful in carrying out the method of the invention.Disclosed also are methods of treating mammals for clinical conditions responsive to prostaglandins, such as, for example, male infertility, epidermal injuries, atonic uterine bleeding, thromboembolic disease and like clinical conditions.

Abstract: A method of improving the endogenous production of prostaglandins by a mammal is disclosed, which comprises administering to the mammal an effective amount of an N-(pyridylalkyl)benzamides. Disclosed also are novel N-(pyridylalkyl)benzamides and therapeutic compositions thereof which are useful in carrying out the method of the invention.Disclosed also are methods of treating mammals for clinical conditions responsive to prostaglandins, such as for example, male infertility, epidermal injuries, atonic uterine bleeding, thromboembolic disease and like clinical conditions.

Abstract: In a data processing system having a plurality of channels that are organized for separately processing the operations of specific I/O devices and the operations that are background to these specific operations, apparatus for transferring the background processing from one channel to another channel to distribute the background processing load. A system of registers and lines connect these registers to the channels for controlling these operations. Each channel processor has a request register for use in designating that background processing has been completed and that processing of a device oriented portion of a channel program is to begin, and a completion register set by an associated I/O processor for use in signifying that processing of a device oriented portion of a channel program has been completed and that background processing is to begin.

Abstract: Apparatus for signalling the occurrence of a match between an address that is supplied to a control store and an address that is to be watched for in a data processing system that executes several instruction streams concurrently. The apparatus signals the occurrence of a storage accessing operation at a location that is uniquely identified only by a virtual address that is longer than the actual address used in accessing the store. Means is provided for comparing the actual address used in accessing the store with the corresponding portion of the complete address, and means is provided for recording the location of an address to be watched for in a particular frame of the store and for signalling a match that occurs in such a frame. The apparatus is useful for testing the operation of the data processing system by relating a recurring malfunction of the system to the execution of an instruction at the address that is watched for.

Abstract: A method of improving the endogenous production of prostaglandins by a mammal is disclosed, which comprises administering to the mammal an effective amount of 1-pyridylalkyl-3-naphthyl-2(thio)ureas. Disclosed also are novel substituted 1-pyridylalkyl-3-naphthyl-2(thio)ureas and therapeutic compositions thereof which are useful in carrying out the method of the invention.Disclosed also are methods of treating mammals for clinical conditions responsive to prostaglandins, such as, for example, male infertility, epidermal injuries, atonic uterine bleeding, thromboembolic disease and like clinical conditions.

Abstract: A method of improving the endogenous production of prostaglandins by a mammal is disclosed, which comprises administering to the mammal an effective amount of certain 1-pyridylalkyl-3-phenylureas. Disclosed also are novel substituted 1-pyridylalkyl-3-phenylureas and therapeutic compositions thereof which are useful in carrying out the method of the invention.Disclosed also are methods of treating mammals for clinical conditions responsive to prostaglandins, such as, for example, male infertility, epidermal injuries, atonic uterine bleeding, thromboembolic disease and like clinical conditions.