Patents by Inventor William A. Catterall

William A. Catterall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DE NOVO DESIGNED ALPHA-HELICAL PROTEIN CHANNELS
    Publication number: 20230192773
    Abstract: Disclosed herein are polypeptide comprising an amino acid sequence at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence of any one of SEQ ID NOS: 1-4, oligomers thereof, and uses thereof.
    Type: Application
    Filed: April 28, 2021
    Publication date: June 22, 2023
    Inventors: Chunfu XU, Peilong LU, Tamer GAMAL EL-DIN, William A. CATTERALL, David BAKER
  • POSITIVE ALLOSTERIC MODULATORS OF THE GABA-A RECEPTOR IN THE TREATMENT OF AUTISM
    Publication number: 20150313913
    Abstract: Provided herein are methods and formulations for treating an Autism Spectrum Disorder using low doses of an agent that enhances signaling through the GABA receptor.
    Type: Application
    Filed: February 4, 2014
    Publication date: November 5, 2015
    Inventors: William A. CATTERALL, Sung HAN
  • Methods and compositions for screening for presynaptic calcium channel blockers
    Patent number: 6090631
    Abstract: Methods and compositions related to the identification of compounds that block neurotransmitter release are disclosed. Using the methods of the present invention, candidate compounds may be screened for the ability to bind to presynaptic calcium channels such that the docking of presynaptic vesicles to presynaptic calcium channels will be inhibited. The present invention also discloses peptides useful in the screening methods.
    Type: Grant
    Filed: November 13, 1995
    Date of Patent: July 18, 2000
    Assignee: University of Washington
    Inventors: William A. Catterall, Zu-Hang Sheng
  • Methods and compositions for screening for presynaptic calcium channel blockers
    Patent number: 5623051
    Abstract: Methods and compositions related to the identification of compounds that block neurotransmitter release are disclosed. Using the methods of the present invention, candidate compounds may be screened for the ability to bind to presynaptic calcium channels such that the docking of presynaptic vesicles to presynaptic calcium channels will be inhibited. The present invention also discloses peptides useful in the screening methods.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: April 22, 1997
    Assignee: University of Washington
    Inventors: William A. Catterall, Zu-Hang Sheng
  • Methods of identifying specific inactivation gate inhibitors of the sodium channel
    Patent number: 5437982
    Abstract: Assay for identifying an inactivation gate inhibitor of a sodium channel, by: establishing first and a second cultures of cells having a wild-type sodium channel and third and a fourth cultures of cells having a noninactivating mutant sodium channel; measuring a baseline sodium current for one or more cells in the first and the second cultures, and a baseline inactivation rate for one or more cells in the third and the fourth cultures; treating the cells in the first and the third cultures with either a candidate inhibitor or an IFM amide control, and the cells in the second and the fourth cultures with an inactive control peptide; measuring a test sodium current in one or more cells in the first and the second cultures, and a test inactivation rate in one or more cells in the third and the fourth cultures; and determining that the candidate inhibitor is an inactivation gate inhibitor of the sodium channel if the test sodium current of the cells in the first culture is lower than the baseline of the first cul
    Type: Grant
    Filed: September 8, 1993
    Date of Patent: August 1, 1995
    Assignee: University of Washington
    Inventors: William A. Catterall, Galen Eaholtz