Patents by Inventor William A. COMRIE

William A. COMRIE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric antigen receptor comprising BCMA nanobody linked to a chimeric intracellular signaling domain
    Patent number: 12263221
    Abstract: The present application relates to functionally improved third generation BCMA-CARs comprising modified intracellular co-stimulatory domains, which can be used in adoptive cell therapy, e.g., in treatment of diseases and disorders such as cancer.
    Type: Grant
    Filed: July 5, 2023
    Date of Patent: April 1, 2025
    Assignee: Neomics Pharmaceuticals LLC
    Inventors: William A. Comrie, Wenshan Hao
  • CHIMERIC ANTIGEN RECEPTOR COMPRISING BCMA NANOBODY LINKED TO A CHIMERIC INTRACELLULAR SIGNALING DOMAIN
    Publication number: 20240009309
    Abstract: The present application relates to functionally improved third generation BCMA-CARs comprising modified intracellular co-stimulatory domains, which can be used in adoptive cell therapy, e.g., in treatment of diseases and disorders such as cancer.
    Type: Application
    Filed: July 5, 2023
    Publication date: January 11, 2024
    Inventors: William A. COMRIE, Wenshan HAO
  • CHIMERIC CO-STIMULATORY PROTEINS COMPRISING MUTANT INTRACELLULAR DOMAINS WITH INCREASED EXPRESSION
    Publication number: 20220220186
    Abstract: The present application relates to functionally optimized intracellular co-stimulatory domains, optionally in combination with cell-intrinsic immune checkpoint inhibitory receptors or immune-stimulatory receptors or portions thereof, which can be used in adoptive cell therapy to treat human diseases and disorders.
    Type: Application
    Filed: January 4, 2022
    Publication date: July 14, 2022
    Inventors: William A. COMRIE, Wenshan HAO