Abstract: Disclosed are substituted (4?-hydroxylphenyl)cycloalkane compounds and substituted (4?-hydroxylphenyl)cycloalkene compounds and there use as selective agonists of the estrogen receptor beta isoform (ER?). The disclosed compounds may be formulated as pharmaceutical compositions and administered for treating diseases associated with ER activity, such as neurological, psychiatric, and/or cell proliferative diseases and disorders as well as for enhancing memory consolidation in subjects in need thereof.

Abstract: The present application relates to a circuit and a transceiver comprising the circuit. The circuit comprises two bus line terminals for coupling to a bus and a bridge circuit comprising two legs. Each leg comprises an adjustable pull resistance and an adjustable push resistance connected in series with a respective one of the two bus line terminals. The adjustable pull resistances and the adjustable push resistances of the bridge circuit enable to independently adjust a driver impedance and to independently adjust a differential driver voltage on the bus. The circuit may further comprise an edge detector is coupled to a transmit data input and configured to detect a transition on the transmit data input and to adjust the impedances of the adjustable pull resistances and the adjustable push resistances in response to the detected transition.

Abstract: Disclosed are substituted (4?-hydroxylphenyl)cycloalkane compounds and there use as selective agonists of the estrogen receptor beta isoform (ER?). The disclosed compounds may be formulated as pharmaceutical compositions and administered to treat diseases associated with ER activity, such as proliferative diseases and disorders and/or psychiatric diseases or disorders.

Abstract: The present application relates to a circuit and a transceiver comprising the circuit. The circuit comprises two bus line terminals for coupling to a bus and a bridge circuit comprising two legs. Each leg comprises an adjustable pull resistance and an adjustable push resistance connected in series with a respective one of the two bus line terminals. The adjustable pull resistances and the adjustable push resistances of the bridge circuit enable to independently adjust a driver impedance and to independently adjust a differential driver voltage on the bus. The circuit may further comprise an edge detector is coupled to a transmit data input and configured to detect a transition on the transmit data input and to adjust the impedances of the adjustable pull resistances and the adjustable push resistances in response to the detected transition.

Abstract: Disclosed are substituted (4?-hydroxylphenyl)cycloalkane compounds and there use as selective agonists of the estrogen receptor beta isoform (ER?). The disclosed compounds may be formulated as pharmaceutical compositions and administered to treat diseases associated with ER activity, such as proliferative diseases and disorders and/or psychiatric diseases or disorders.

Abstract: A building structure (10) which, in its assembled form, defines a polyhedral framework having an irregular hexagonal base (12), a regular hexagonal top (14) and a number of supports (16, 18) which are interposed between the top (14) and the base (12) and which, in use, support the top (14) on the base (12). The building structure (10) can be assembled from a kit of parts comprising a number of common components and without the need for skilled labour or specialist tools in its construction.

Abstract: A powder metal formulation includes a solid lubricant and is particularly useful for the production of powder metal scroll compressors.

Abstract: Described are digestive/laxative compositions and methods of manufacture and use of same. In a preferred embodiment, the invention provides for a digestive/laxative composition including actinidin. The actinidin is preferably contributed by inclusion of fruit of genus actinidia, or a product thereof. Preferably, the process for forming the composition includes a method in which the fruit is processed at a temperature below that causing significant degradation of actinidin present, this temperature being preferably in the range of ?40° C. to 40° C. Methods of administration of the composition are also described.

Abstract: Described are digestive/laxative compositions and methods of manufacture and use of same. In a preferred embodiment, the invention provides for a digestive/laxative composition including actinidin. The actinidin is preferably contributed by inclusion of fruit of genus actinidia, or a product thereof. Preferably, the process for forming the composition includes a method in which the fruit is processed at a temperature below that causing significant degradation of actinidin present, this temperature being preferably in the range of ?40° C. to 40° C. Methods of administration of the composition are also described.

Abstract: The use of actinidin as a digestive/laxative aid. Method of obtaining actinidin from fruit.

Abstract: A medicament for administration to a non-human animal, wherein the medicament includes at Least partially hydrolysed protein and one or more pharmacologically active substances. In a preferred embodiment, the protein is derived from meat which is hydrolysed using a fruit-derived proteolytic enzyme such as actinidin from kiwifruit which enhances the palatability of the resulting hydrolysate. A method of manufacturing the medicament, and a method of medicating a non-human animal by administering to the animal a medicament are also disclosed.

Abstract: A process of producing kiwifruit seed oil involves first sterilizing the picked and selected ripe kiwifruit by flame, chlorine wash, or ozone impregnated water wash, followed by a fresh water rinse. The fruit is then cut using a water laser to minimize seed damage. Next the skin is separated from the fruit. Then the pulp is gently separated from the seed ensuring minimal seed coat damage. The resulting seed is cleaned whilst ensuring minimal seed coat damage. Then seed is then dried using cool temperature drying. The seed is stored at a cool temperature until it is needed for oil extraction. Crushing of the seed takes place immediately prior to the super critical extraction process. Super critical extraction using liquid carbon dioxide extracts the kiwifruit oil from the crushed seeds. The oil is the stabilized using a natural antioxidant such as rosemary oil.

Abstract: A switch control circuit (416, 402, 418, 422) and method are provided for transistor-implemented switches (405, 413, 408, 414) of an integrated floating power transfer device (400, 500). The device includes a floating bus (403, 410) driven by a power system which includes a charge pump circuit (419, 408, 414, 420). At least one switch circuit (405, 413) is coupled to the floating bus and the power system for facilitating charging of the floating bus. The switch control circuit (416, 402, 418, 422) includes a level shifting circuit (402) for adjusting a control signal to the at least one switch circuit notwithstanding floating of an input voltage signal thereto to facilitate operation of the switch circuit.

Abstract: A biological agent detector detects the presence of any biological agents, such as anthrax or other biological warfare agents, in a sample of air. The biological agent detector includes a bio-concentrator that concentrates an aerosol and a pyrolyzer portion including two detecting devices. One detecting device operates in a sample collection mode and collects a sample of air when the other detecting device operates in a sample analysis mode and analyzes a sample of air. After a predetermined amount of time, the detecting devices switch functions, providing continuous sampling of air.

Abstract: A protection circuit and method are provided for a floating power transfer device having one or more switches for controlling charging of a reservoir capacitor across which a load is applied when in use. The protection circuit includes a control circuit, a fault detection circuit and a precharge driver circuit. The control circuit at least partially controls switching of the at least one switch, while the fault detection circuit detects when a fault in the floating power transfer device or the load occurs and sends a fault detect signal to the control circuit in response thereto. The precharge driver circuit, which is enabled by the control circuit responsive to receipt of the fault detect signal, attempts to precharge the reservoir capacitor to a voltage level sufficient for switching of the one or more switches to proceed without damaging the switches.

Abstract: A disposable fluid container (20) comprises an integrated pump motive assembly (50) for pumping fluid from an interior of the container. In some example embodiments, the integrated pump motive assembly (50) is situated at least partially within the container housing, e.g., at least partially or even completely submerged inside a fluid reservoir (30) defined by the container housing (22). In other example embodiments, the pump motive assembly is outside the fluid reservoir (30), yet still integrally formed with the container. In yet other embodiments, the pump motive assembly is in a lid (194) of the container. As one aspect of this disposable pump-integrated container technology, the pump motive assembly comprises a displaceable electrodynamic actuator, such as (for example) piezoelectric diaphragm pump, taking any of various configurations.

Abstract: Embodiments of fluid storage containers (312) comprise a displaceable electrodynamic valve (344) for selectively regulating release of fluid from the container. The fluid storage container has a port (342) and comprises means for defining a reservoir (330) for accommodating a pressurizing a fluid. A displaceable electrodynamic valve selectively opens and closes the port and thereby regulates release of the pressurized fluid from the container. In some implementations, the container has a lid (400) and the port is provided in the container lid. In other implementations, the container has a container body, and the port is provided in the container body. The displaceable electrodynamic valve (344) can take various configurations (e.g., flapper, solenoid) and various forms (e.g., piezoelectric valve) in differing example embodiments. In some embodiments a compressor (361) is provided for pressurizing the fluid, and can also take various forms.

Abstract: A protection circuit and method are provided for a floating power transfer device having one or more switches for controlling charging of a reservoir capacitor across which a load is applied when in use. The protection circuit includes a control circuit (43), a fault detection circuit (33) and a precharge driver circuit (47). The control circuit (43) at least partially controls switching of the at least one switch, while the fault detection circuit (33) detects when a fault in the floating power transfer device or the load occurs and sends a fault detect signal to the control circuit (43) in response thereto. The precharge driver circuit (47), which is enabled by the control circuit (43) responsive to receipt of the fault detect signal, attempts to precharge the reservoir capacitor (35) to a voltage level sufficient for switching of the one or more switches (36, 37) to proceed without damaging the switches (36, 37).

Abstract: A chemical biological detection system detects the presence of biological agents in the air. The system includes a pyrolyzer having an inlet through which air is drawn into the pyrolyzer and a pyrotube that collects a sample of particles extracted from the air. The pyrolyzer further includes an exhaust line that exhausts the air drawn into the pyrolyzer and a sample line that directs the gases eluted from the sample collected in the pyrotube to a mass spectrometer for sample identification. After the sample is collected in the pyrotube, the sample is analyzed. A small droplet of a methylating reagent is added to the sample. If the sample includes any biological agents, the methylating reagent derivatizes organic materials to make them more volatile. The sample is then pyrolyzed, and the eluted gas sample is drawn through the sample line and into the mass spectrometer for identification of any biological agents.

Abstract: A switch control circuit (416, 402, 418, 422) and method are provided for transistor-implemented switches (405, 413, 408, 414) of an integrated floating power transfer device (400, 500). The device includes a floating bus (403, 410) driven by a power system which includes a charge pump circuit (419, 408, 414, 420). At least one switch circuit (405, 413) is coupled to the floating bus and the power system for facilitating charging of the floating bus. The switch control circuit (416, 402, 418, 422) includes a level shifting circuit (402) for adjusting a control signal to the at least one switch circuit notwithstanding floating of an input voltage signal thereto to facilitate operation of the switch circuit.