Abstract: The present invention generally relates to the treatment of ulcerative colitis with an anti-IL-23p19 antibody, in particular dosage regimens for the treatment of the disease.

Abstract: The present invention generally relates to the treatment of ulcerative colitis with an anti-IL-23p19 antibody, in particular dosage regimens for the treatment of the disease.

Abstract: The present invention generally relates to the treatment of psoriasis with an antibody that binds to the p19 subunit of human IL-23, in particular dosage regimens for the treatment of the disease.

Abstract: The present invention generally relates to the treatment of Crohn's Disease with an anti-IL-23p19 antibody, particularly dosage regimens for the treatment of the disease.

Abstract: The present invention generally relates to the treatment of ulcerative colitis with an anti-IL-23p19 antibody, in particular dosage regimens for the treatment of the disease.

Abstract: The present invention is directed to a system and a method for accurately locating a penetrating-type weapon within a shelter for detonation at a desired target site. The method includes detecting a deceleration threshold event indicative of the penetrating weapon impacting and traversing a layer of shelter having certain material or structural characteristics (e.g., a “hard” or a “thick” layer). A delayed detonation program or process is enabled upon detection of the threshold event. For example, a delayed detonation program or process may include layer counting, void counting, or a combination of layer and void counting until the desired number of layers (and/or voids) of a shelter has been detected, at which time the weapon may be detonated. Any deceleration events that occur prior to the deceleration threshold event are ignored to minimize the potential failure of detecting specific types of layers including certain types of “soft” or “thin” layers.

Abstract: The present invention is directed to a system and a method for accurately locating a penetrating-type weapon within a shelter for detonation at a desired target site. The method includes detecting a deceleration threshold event indicative of the penetrating weapon impacting and traversing a layer of shelter having certain material or structural characteristics (e.g., a “hard” or a “thick” layer). A delayed detonation program or process is enabled upon detection of the threshold event. For example, a delayed detonation program or process may include layer counting, void counting, or a combination of layer and void counting until the desired number of layers (and/or voids) of a shelter has been detected, at which time the weapon may be detonated. Any deceleration events that occur prior to the deceleration threshold event are ignored to minimize the potential failure of detecting specific types of layers including certain types of “soft” or “thin” layers.

Abstract: Applicants have invented a guidance system for guiding a projectile, the projectile having a body portion capable of being spun in a first direction and a nose portion connected to the body portion by a spin control coupling, the nose portion being capable of being spun in a second direction. The nose portion including first and second aerodynamic surfaces fixedly attached to the nose portion and configured and arranged to cause the nose portion to spin in a second direction during projectile flight. The nose portion including third and fourth aerodynamic surfaces fixedly attached to the nose portion, which are configured and arranged such that when the nose portion is spinning the third and fourth aerodynamic surfaces have no net effect on projectile flight, but when the nose portion is despun using the spin control coupling, the third and fourth aerodynamic surfaces induce both a moment and a lateral force to the nose, causing the projectile flight path to change.

Abstract: A proximity sensor for use with a guidance system of a smart bomb including a ranging radar proximity sensor configured for mounting on a smart bomb and a radome connected to the ranging radar proximity sensor. A laser radiation sensor system is attached to the proximity sensor, which is configured and arranged to detect laser radiation reflected from a target which passes through the radome and output the azimuth and elevation angles to the target to the guidance system.

Abstract: Applicants have invented a guidance system for guiding a projectile, the projectile having a body portion capable of being spun in a first direction and a nose portion connected to the body portion by a spin control coupling, the nose portion being capable of being spun in a second direction. The nose portion including first and second aerodynamic surfaces fixedly attached to the nose portion and configured and arranged to cause the nose portion to spin in a second direction during projectile flight. The nose portion including third and fourth aerodynamic surfaces fixedly attached to the nose portion, which are configured and arranged such that when the nose portion is spinning the third and fourth aerodynamic surfaces have no net effect on projectile flight, but when the nose portion is despun using the spin control coupling, the third and fourth aerodynamic surfaces induce both a moment and a lateral force to the nose, causing the projectile flight path to change.

Abstract: A proximity sensor for use with a guidance system of a smart bomb including a ranging radar proximity sensor configured for mounting on a smart bomb and a radome connected to the ranging radar proximity sensor. A laser radiation sensor system is attached to the proximity sensor, which is configured and arranged to detect laser radiation reflected from a target which passes through the radome and output the azimuth and elevation angles to the target to the guidance system.

Abstract: An electromechanical apparatus for testing IC chips includes a chip holding subassembly, a power converter subassembly, and a temperature regulating subassembly which are squeezed together in multiple sets by respective pressing mechanisms; and this apparatus uses a generic structure for both the chip holding subassembly and the power converter subassembly. This generic structure is comprised of a planer substrate having first and second faces that are opposite to each other and are surrounded by an edge that is free of any electrical edge connectors. To use the above generic subassembly as the chip holding subassembly, an electrical components on the first face of the substrate include sockets which hold the chips that are tested. To use the above generic subassembly as the power converter subassembly, the electrical components on the first face of the substrate include electrical power converters for the chips that are tested.

Abstract: Disclosed are methods for the detection, diagnosis and prediction of tamoxifen-resistant breast cancer. Genetic and antibody probes and methods useful in determining the presence and monitoring the progression of breast cancer are also described. The methods involve determining polypeptide or mRNA expression of the genes encoding the angiogenic agents or receptors TIE-2, EDNRA, TGF&bgr;3, TGFR&bgr;III, VEGFR1, VEGF or bFGFR. Also described are procedures for combination therapies utilizing antiangiogenic agents or gene therapy directed towards TIE-2, EDNRA, TGF&bgr;3, TGFR&bgr;III, VEGFR1, VEGF or bFGFR, in combination with tamoxifen treatment of breast cancer.

Abstract: An electromechanical apparatus for testing IC chips includes a chip holding subassembly, a power converter subassembly, and a temperature regulating subassembly which are squeezed together in multiple sets by respective pressing mechanisms; and this apparatus uses a generic structure for both the chip holding subassembly and the power converter subassembly. This generic structure is comprised of a planer substrate having first and second faces that are opposite to each other and are surrounded by an edge that is free of any electrical edge connectors. Distributed on the first face of the substrate are a plurality of electrical components that are used in testing the chips; and, distributed on the second face of the substrate are a plurality of electrical contacts which are connected through the substrate to the electrical components on the first face. These electrical contacts get pressed against mating contacts, and they carry all electrical power and all electrical signals for the chips that are tested.

Abstract: An electromechanical apparatus for testing integrated chips includes a chip holding subassembly, a power converter subassembly, and a temperature regulating subassembly, which are squeezed together in multiple sets, by respective pressing mechanisms. One benefit which is achieved with this electromechanical apparatus is that by pressing the temperature regulating subassembly against the chip holding subassembly, heat can be added/removed from the chips by conduction; and thus the temperature of the chips can be regulated accurately. Another benefit which is achieved with this electromechanical apparatus is that by pressing the power converter subassembly against the chip holding subassembly, the distance between the chips that are tested and the power supplies for those chips is made small. Consequently, the chip voltages can easily be kept constant while the chip power dissipation changes rapidly as the chips are tested.

Abstract: A mechanical assembly for regulating the temperature of a chip is comprised of a heat exchanger which has a face for mating with a planar surface on the chip. A frame is coupled to the heat exchanger such that the face of the heat exchanger is exposed and can contact the planar surface of the chip. And, the face of the heat exchanger has a shape which makes contact with the entire planar surface on the chip except for each of its corners. One particular embodiment of the heat exchanger has four grooves which extend from the face and which respectively align with the corners of the chip. Due to those grooves, initial contact between the face on the heat exchanger and the planar surface on the chip occurs on an edge of the chip which is spaced-apart from a corner. Consequently, the chance of breaking the tip of a corner off of the chip is reduced.

Abstract: A device for ciphering a block of data bits under control of a cipher key. The cipher device performs a ciphering process for the block of data by carrying out an operation in which the block of data bits is first expanded by duplicating predetermined ones of the data bits. The data bits of the expanded block are combined by modulo-2 addition with an equal number of cipher key bits, selected in accordance with an arbitrary but fixed permutation, to produce a plurality of multi-bit segments forming the arguments for a plurality of different nonlinear substitution function boxes. The substitution boxes perform a plurality of nonlinear transformation functions to produce a substitution set of bits which are equal in number to the number of data bits in the first half of the message block. The substitution set of bits is then subjected to a linear transformation in accordance with an arbitrary but fixed permutation.

Abstract: A device for ciphering message blocks of data bits under control of a cipher key. The cipher device performs an enciphering process for each message block of data by carrying out a predetermined number of iteration operations in the first of which a first half of the message block of data bits is first expanded by duplicating predetermined ones of the data bits. The data bits of the expanded message block are combined by modulo-2 addition with an equal number of cipher key bits, selected in accordance with an arbitrary but fixed permutation, to produce a plurality of multi-bit segments forming the arguments for a plurality of different nonlinear substitution function boxes. The substitution boxes perform a plurality of nonlinear transformation functions to produce a substitution set of bits which are equal in number to the number of data bits in the first half of the message block. The substitution set of bits is then subjected to a linear transformation in accordance with an arbitrary but fixed permutation.