Abstract: Provided herein are compounds useful for the treatment of various proliferative diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions, and may be used in methods of treatment and/or prophylaxis of proliferative diseases, including cancer, and more specifically, pancreatic cancer.

Abstract: An electronic watch may include a housing at least partially defining an interior cavity divided into at least a first volume and a second volume, a pressure-sensing component positioned within the first volume, a speaker positioned within the first volume, a processor positioned within the second volume, a battery positioned within the second volume, and a barometric vent that allows air pressure equalization between the first volume and an external environment.

Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.

Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.

Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.

Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.

Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.

Abstract: The present technology is generally directed to systems and methods for improving quenched coke recovery. More specifically, some embodiments are directed to systems and methods utilizing one or more of a screen, barrier, or reflector panel to contain or redirect coke during or after quenching. In a particular embodiment, a quench car system for containing coke includes a quench car having a base, a plurality of sidewalls, and a top portion. The system can further include a permeable barrier covering at least a portion of the top of the quench car, wherein the permeable barrier has a plurality of apertures therethrough.

Abstract: The present technology is generally directed to systems and methods for improving quenched coke recovery. More specifically, some embodiments are directed to systems and methods utilizing one or more of a screen, barrier, or reflector panel to contain or redirect coke during or after quenching. In a particular embodiment, a quench car system for containing coke includes a quench car having a base, a plurality of sidewalls, and a top portion. The system can further include a permeable barrier covering at least a portion of the top of the quench car, wherein the permeable barrier has a plurality of apertures therethrough.

Abstract: The present technology is generally directed to systems and methods for improving quenched coke recovery. More specifically, some embodiments are directed to systems and methods utilizing one or more of a screen, barrier, or reflector panel to contain or redirect coke during or after quenching. In a particular embodiment, a quench car system for containing coke includes a quench car having a base, a plurality of sidewalls, and a top portion. The system can further include a permeable barrier covering at least a portion of the top of the quench car, wherein the permeable barrier has a plurality of apertures therethrough.

Abstract: A laser system for generating optical pulses at an operating wavelength of the laser system. The system has an optical resonator comprising first and second reflectors, and a tapered optical fiber disposed between the first and second reflectors. The tapered optical fiber has a core which has a tapered input section which tapers from single mode to multimode at the laser operating wavelength, an inner section of substantially constant diameter capable of supporting multiple modes at the laser operating wavelength and a tapered output section which tapers from a first diameter to a second diameter that is smaller than the first diameter.

Abstract: The present technology is generally directed to systems and methods for improving quenched coke recovery. More specifically, some embodiments are directed to systems and methods utilizing one or more of a screen, barrier, or reflector panel to contain or redirect coke during or after quenching. In a particular embodiment, a quench car system for containing coke includes a quench car having a base, a plurality of sidewalls, and a top portion. The system can further include a permeable barrier covering at least a portion of the top of the quench car, wherein the permeable barrier has a plurality of apertures therethrough.

Abstract: The present technology is generally directed to systems and methods for improving quenched coke recovery. More specifically, some embodiments are directed to systems and methods utilizing one or more of a screen, barrier, or reflector panel to contain or redirect coke during or after quenching. In a particular embodiment, a quench car system for containing coke includes a quench car having a base, a plurality of sidewalls, and a top portion. The system can further include a permeable barrier covering at least a portion of the top of the quench car, wherein the permeable barrier has a plurality of apertures therethrough.

Abstract: A laser system for generating optical pulses at an operating wavelength of the laser system. The system has an optical resonator comprising first and second reflectors, and a tapered optical fiber disposed between the first and second reflectors. The tapered optical fiber has a core which has a tapered input section which tapers from single mode to multimode at the laser operating wavelength, an inner section of substantially constant diameter capable of supporting multiple modes at the laser operating wavelength and a tapered output section which tapers from a first diameter to a second diameter that is smaller than the first diameter.

Abstract: A laser system for generating optical pulses at an operating wavelength of the laser system. The system has an optical resonator comprising first and second reflectors, and a tapered optical fiber disposed between the first and second reflectors. The tapered optical fiber has a core which has a tapered input section which tapers from single mode to multimode at the laser operating wavelength, an inner section of substantially constant diameter capable of supporting multiple modes at the laser operating wavelength. The tapered optical fiber can include a tapered output section wherein the core tapers from a first diameter to a second diameter that is smaller than the first diameter.

Abstract: Preformed stabilizers useful for the production of low viscosity, high solids polymer polyols are produced by free-radical polymerization of: (a) at least one ethylenically unsaturated macromolecule or macromer with (b) at least three different ethylenically unsaturated monomers in the presence of (c) at least one free-radical polymerization initiator, and, optionally, (d) a liquid diluent, and, optionally, (e) a chain transfer agent.

Abstract: The present technology is generally directed to systems and methods for improving quenched coke recovery. More specifically, some embodiments are directed to systems and methods utilizing one or more of a screen, barrier, or reflector panel to contain or redirect coke during or after quenching. In a particular embodiment, a quench car system for containing coke includes a quench car having a base, a plurality of sidewalls, and a top portion. The system can further include a permeable barrier covering at least a portion of the top of the quench car, wherein the permeable barrier has a plurality of apertures therethrough.

Abstract: A laser system for generating optical pulses at an operating wavelength of the laser system. The system has an optical resonator comprising first and second reflectors, and a tapered optical fiber disposed between the first and second reflectors. The tapered optical fiber has a core which has a tapered input section which tapers from single mode to multimode at the laser operating wavelength, an inner section of substantially constant diameter capable of supporting multiple modes at the laser operating wavelength and a tapered output section which tapers from a first diameter to a second diameter that is smaller than the first diameter.

Abstract: Preformed stabilizers useful for the production of low viscosity, high solids polymer polyols are produced by free-radical polymerization of: (a) at least one ethylenically unsaturated macromolecule or macromer with (b) at least three different ethylenically unsaturated monomers in the presence of (c) at least one free-radical polymerization initiator, and, optionally, (d) a liquid diluent, and, optionally, (e) a chain transfer agent.

Abstract: A gel for application to a wound, comprising a mixture of citrus complex carbohydrates, a cellulose derivative, a polyol component and water, wherein said citrus complex carbohydrates are cross-linked to said cellulose derivative by an ionic cross-linking agent.