Abstract: An approach for transforming a large dataset using user interface-based transformations applied to a sample of the dataset is disclosed. The sample of the large dataset has the same or similar format as the large dataset. A user can quickly apply transformations to the sample dataset using UI-based instructions. The UI-based instructions can be used to create a transformation job that can be configured to run on a backed database, such as a distributed database, to apply the transformations to the large dataset.

Abstract: The invention is directed to HIV-1 neutralizing antibodies and methods for their uses.

Abstract: Transcatheter delivery systems, delivery catheters and associated methods for percutaneous delivery of prosthetic mitral valves using a retrograde approach are disclosed herein. A heart valve delivery system configured in accordance herewith includes a delivery catheter having an elongated tubular component and an articulation assembly at a distal end thereof. The articulation assembly includes an arm portion coupled to the tubular component by an elbow or hinge portion. In a closed, delivery state, the elbow portion positions the arm portion generally parallel to the tubular component for delivery of the delivery catheter through the vasculature. In an open, deployed state, the elbow portion positions the arm portion in a non-axial direction with respect to a longitudinal axis of the tubular component for orienting and positioning a prosthetic valve device carried by the arm portion, e.g., within the native mitral valve region.

Abstract: Systems and methods for determining structural variation and phasing using variant call data obtained from nucleic acid of a biological sample are provided. Sequence reads are obtained, each comprising a portion corresponding to a subset of the test nucleic acid and a portion encoding a barcode independent of the sequencing data. Bin information is obtained. Each bin represents a different portion of the sample nucleic acid. Each bin corresponds to a set of sequence reads in a plurality of sets of sequence reads formed from the sequence reads such that each sequence read in a respective set of sequence reads corresponds to a subset of the nucleic acid represented by the bin corresponding to the respective set. Binomial tests identify bin pairs having more sequence reads with the same barcode in common than expected by chance. Probabilistic models determine structural variation likelihood from the sequence reads of these bin pairs.

Abstract: Systems and methods for determining structural variation and phasing using variant call data obtained from nucleic acid of a biological sample are provided. Sequence reads are obtained, each comprising a portion corresponding to a subset of the test nucleic acid and a portion encoding a barcode independent of the sequencing data. Bin information is obtained. Each bin represents a different portion of the sample nucleic acid. Each bin corresponds to a set of sequence reads in a plurality of sets of sequence reads formed from the sequence reads such that each sequence read in a respective set of sequence reads corresponds to a subset of the nucleic acid represented by the bin corresponding to the respective set. Binomial tests identify bin pairs having more sequence reads with the same barcode in common than expected by chance. Probabilistic models determine structural variation likelihood from the sequence reads of these bin pairs.

Abstract: Transcatheter delivery systems, delivery catheters and associated methods for percutaneous delivery of prosthetic mitral valves using a retrograde approach are disclosed herein. A heart valve delivery system configured in accordance herewith includes a delivery catheter having an elongated tubular component and an articulation assembly at a distal end thereof. The articulation assembly includes an arm portion coupled to the tubular component by an elbow or hinge portion. In a closed, delivery state, the elbow portion positions the arm portion generally parallel to the tubular component for delivery of the delivery catheter through the vasculature. In an open, deployed state, the elbow portion positions the arm portion in a non-axial direction with respect to a longitudinal axis of the tubular component for orienting and positioning a prosthetic valve device carried by the arm portion, e.g., within the native mitral valve region.

Abstract: Transcatheter delivery systems, delivery catheters and associated methods for percutaneous delivery of prosthetic mitral valves using a retrograde approach are disclosed herein. A heart valve delivery system configured in accordance herewith includes a delivery catheter having an elongated tubular component and an articulation assembly at a distal end thereof. The articulation assembly includes an arm portion coupled to the tubular component by an elbow or hinge portion. In a closed, delivery state, the elbow portion positions the arm portion generally parallel to the tubular component for delivery of the delivery catheter through the vasculature. In an open, deployed state, the elbow portion positions the arm portion in a non-axial direction with respect to a longitudinal axis of the tubular component for orienting and positioning a prosthetic valve device carried by the arm portion, e.g., within the native mitral valve region.

Abstract: Transcatheter delivery systems, delivery catheters and associated methods for percutaneous delivery of prosthetic mitral valves using a retrograde approach are disclosed herein. A heart valve delivery system configured in accordance herewith includes a delivery catheter having an elongated tubular component and an articulation assembly at a distal end thereof. The articulation assembly includes an arm portion coupled to the tubular component by an elbow or hinge portion. In a closed, delivery state, the elbow portion positions the arm portion generally parallel to the tubular component for delivery of the delivery catheter through the vasculature. In an open, deployed state, the elbow portion positions the arm portion in a non-axial direction with respect to a longitudinal axis of the tubular component for orienting and positioning a prosthetic valve device carried by the arm portion, e.g., within the native mitral valve region.

Abstract: Systems and methods for determining structural variation and phasing using variant call data obtained from nucleic acid of a biological sample are provided. Sequence reads are obtained, each comprising a portion corresponding to a subset of the test nucleic acid and a portion encoding a barcode independent of the sequencing data. Bin information is obtained. Each bin represents a different portion of the sample nucleic acid. Each bin corresponds to a set of sequence reads in a plurality of sets of sequence reads formed from the sequence reads such that each sequence read in a respective set of sequence reads corresponds to a subset of the nucleic acid represented by the bin corresponding to the respective set. Binomial tests identify bin pairs having more sequence reads with the same barcode in common than expected by chance. Probabilistic models determine structural variation likelihood from the sequence reads of these bin pairs.

Abstract: This invention generally relates to an activity wipe dispenser and multi-pack arrangement for use during a variety of different activities; and, more particularly, to an activity wipe dispenser adapted for attachment to different articles and for storage of used wipes as well as to a multi-pack arrangement comprising a plurality of activity wipe dispensers each having different and complementary active components particularly useful in connection with different aspects of a specific activity.

Abstract: A dual poppet low leak variable bleed solenoid valve, including a solenoid portion with an adjustable end cap disposed through the solenoid. Exhaust ports are disposed about the end cap. A hydraulic portion has a valve housing that is connectable to the solenoid portion. The hydraulic portion has a control volume formed within, and a supply port is connected through the valve housing. A valve shaft is slidably disposed through the solenoid portion and extends longitudinally into the hydraulic portion. A first end of the valve shaft terminates in the solenoid portion forming a primary valve, and a second end of the valve shaft terminates in the hydraulic portion forming a secondary valve. The valve shaft further has a hollow channel disposed through the valve shaft to allow the passage of a fluid medium between the first end and second end of the valve shaft.

Abstract: An apparatus is provided, comprising a belt configured to be worn around a person's waist, and a holder secured to the belt. The holder is configured to hold onto a water-tow sport handle used for water skiing and the like. The holder can hold the water-tow sport handle while the belt is being worn around the person's waist and as the handle is being pulled away from the belt, for example by a rope attached to the rear of a watercraft. The holder advantageously comprises a plate member slidably secured to the belt, and a holding element hingedly secured to the plate member. The holding element is preferably a rigid hook that is configured to hold onto the water-tow sport handle. The hook can be hingedly secured to the plate member by a break-away pin configured to break at a threshold shear stress. During use, the pin advantageously breaks to release the portion of the holder that holds onto the water-tow sport handle when the user falls during skiing, wakeboarding, or the like.

Abstract: A pivoting bed trailer to be towed behind a motor vehicle for transporting a wheeled vehicle includes a main frame having a trailer hitch at a front end for coupling with the motor vehicle and a rearward end that engages the ground in an inclined loading condition and supported horizontally above the ground in a transporting condition. The main frame includes longitudinally extending guide rails for laterally aligning the vehicle. A pivot frame frontally and laterally bounds the main frame and the guide rails and is connected to said main frame at a transverse pivotal connection. The pivot frame includes pair of laterally spaced wheel assemblies carried by leaf spring below the pivot frame forward of the pivotal connection whereby rotation of the pivot frame about the wheels raises and lowers the transverse pivotal connection and moves the main frame between the loading condition and the transporting condition.

Abstract: A Venturi vent valve is disclosed suitable for relieving pressure differentials in sewer systems and preventing the escape of odorous gases. The valve consists of a flared tube containing a conical valve so that the annulus forms a Venturi chamber. The conical valve is mounted axially on a rod that engages in bushes attached to the tubular body and an annular base plate and constrains the valve to move axially. The conical valve rests on a rubber washer secured and sealed to the tubular body by the base plate and prevents the escape of fluids by its own weight. The conical valve lifts off the rubber washer to admit a flow of air when the pressure in the sewer system is less than ambient and the valve opening is maintained by the pressure differential, the venturi effect and the viscous forces acting on the conical valve.

Abstract: A pet bed and enclosure device specifically designed for cats includes a spring support device from which is suspended a cloth panel bed. The spring support device includes an upper square frame supported over a lower square frame by two spring steel members attached at a rear section of the upper frame and angled forwardly and attached to the front section of the base frame. A fabric cover enclosure is supported by resilient support members pulled into a round shape by tab ends extending from each corner of the cover which wrap around the upper frame and hook onto horizontal hook members extending inwardly from the corners of the upper frame. A hole in the cover allows the cat to enter the enclosure and rest on the cloth bed that is springably supported.