Patents by Inventor William A. Horton
William A. Horton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230349921Abstract: The present invention provides methods for determining bone growth velocity comprising: (a) measuring an amount of a collagen X marker in a sample obtained from a subject in need thereof; and (b) comparing the amount of collagen X marker measured in step (a) with a collagen X marker standard curve, wherein the amount of collagen X marker is measured using at least two reagents. In an embodiment, there is at least one capture reagent and at least one detection reagent. In a preferred embodiment for measuring CXM, the capture reagent is the aptamer SOMA1 and the detection reagent is the monoclonal antibody mAb X34. The present invention further provides methods for treating diseases, disorders or conditions comprising receiving an identification of an amount of CXM in a sample, wherein the amount of CXM has been identified using a combination of SOMA1 and mAb X34 as CXM-binding reagents, and administering a treatment in light of the amount of CXM in the sample.Type: ApplicationFiled: February 23, 2023Publication date: November 2, 2023Inventors: William A. Horton, Gregory P. Lunstrum, Ryan F. Coghlan, Jon A. Oberdorf
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Publication number: 20220065870Abstract: The present invention provides methods for determining bone growth velocity comprising: (a) measuring an amount of a collagen X marker in a sample obtained from a subject in need thereof; and (b) comparing the amount of collagen X marker measured in step (a) with a collagen X marker standard curve, wherein the amount of collagen X marker is measured using at least two reagents. In an embodiment, there is at least one capture reagent and at least one detection reagent. In a preferred embodiment for measuring CXM, the capture reagent is the aptamer SOMA1 and the detection reagent is the monoclonal antibody mAb X34. The present invention further provides methods for treating diseases, disorders or conditions comprising receiving an identification of an amount of CXM in a sample, wherein the amount of CXM has been identified using a combination of SOMA1 and mAb X34 as CXM-binding reagents, and administering a treatment in light of the amount of CXM in the sample.Type: ApplicationFiled: November 11, 2021Publication date: March 3, 2022Inventors: William A. Horton, Gregory P. Lunstrum, Ryan F. Coghlan, Jon A. Oberdorf
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Publication number: 20210223263Abstract: The present invention provides methods for determining bone growth velocity comprising: (a) measuring an amount of a collagen X marker in a sample obtained from a subject in need thereof; and (b) comparing the amount of collagen X marker measured in step (a) with a collagen X marker standard curve, wherein the amount of collagen X marker is measured using at least two reagents. In an embodiment, there is at least one capture reagent and at least one detection reagent. In a preferred embodiment for measuring CXM, the capture reagent is the aptamer SOMA1 and the detection reagent is the monoclonal antibody mAb X34. The present invention further provides methods for treating diseases, disorders or conditions comprising receiving an identification of an amount of CXM in a sample, wherein the amount of CXM has been identified using a combination of SOMA1 and mAb X34 as CXM-binding reagents, and administering a treatment in light of the amount of CXM in the sample.Type: ApplicationFiled: March 29, 2021Publication date: July 22, 2021Inventors: William A. Horton, Gregory P. Lunstrum, Ryan F. Coghlan, Jon A. Oberdorf
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Publication number: 20200378990Abstract: The present invention provides methods for determining bone growth velocity comprising: (a) measuring an amount of a collagen X marker in a sample obtained from a subject in need thereof; and (b) comparing the amount of collagen X marker measured in step (a) with a collagen X marker standard curve, wherein the amount of collagen X marker is measured using at least two reagents. In an embodiment, there is at least one capture reagent and at least one detection reagent. In a preferred embodiment for measuring CXM, the capture reagent is the aptamer SOMA1 and the detection reagent is the monoclonal antibody mAb X34. The present invention further provides methods for treating diseases, disorders or conditions comprising receiving an identification of an amount of CXM in a sample, wherein the amount of CXM has been identified using a combination of SOMA1 and mAb X34 as CXM-binding reagents, and administering a treatment in light of the amount of CXM in the sample.Type: ApplicationFiled: August 11, 2020Publication date: December 3, 2020Inventors: William A. Horton, Gregory P. Lunstrum, Ryan F. Coghlan, Jon A. Oberdorf
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Patent number: 10542965Abstract: The use of red or near infrared light upon neurons of the lumbar plexus that are in distress due to retraction-induced ischemia. The surgeon may protect nerves made ischemic in the surgery by: a) making an incision in a patient, b) inserting an access device into the patient through the incision to at least partially create a path to a spine of the patient, and c) irradiating nervous tissue adjacent the path with an amount of NIR or red light effective to provide neuroprotection.Type: GrantFiled: October 31, 2016Date of Patent: January 28, 2020Assignee: DePuy Synthes Products, Inc.Inventors: Thomas M. DiMauro, William Horton
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Patent number: 10499898Abstract: The use of red or near infrared light upon neurons of the lumbar plexus that are in distress due to retraction-induced ischemia. The surgeon may protect nerves made ischemic in the surgery by: a) making an incision in a patient, b) inserting an access device into the patient through the incision to at least partially create a path to a spine of the patient, and c) irradiating nervous tissue adjacent the path with an amount of NIR or red light effective to provide neuroprotection.Type: GrantFiled: October 6, 2017Date of Patent: December 10, 2019Assignee: DePuy Synthes Products, Inc.Inventors: Thomas M. DiMauro, William Horton
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Patent number: 10349930Abstract: The use of red or near infrared light upon neurons of the lumbar plexus that are in distress due to retraction-induced ischemia. The surgeon may protect nerves made ischemic in the surgery by: a) making an incision in a patient, b) inserting an access device into the patient through the incision to at least partially create a path to a spine of the patient, and c) irradiating nervous tissue adjacent the path with an amount of NIR or red light effective to provide neuroprotection.Type: GrantFiled: October 6, 2016Date of Patent: July 16, 2019Assignee: DePuy Synthes Products, Inc.Inventors: Thomas M DiMauro, William Horton
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Patent number: 10266324Abstract: There is provided an adjustable fastening device configured to engage a support to provide a tether for the attachment of a tensioned line. The adjustable fastening device includes a plate, and an adjustable collar configured to extend around the support and securely engage with the plate in operation. There is also provided a tensioning mechanism configured to seat against the support and extend in length to drive the support and the plate apart in operation when the plate is securely engaged with the collar. In this way the plate is moved away from the support to thereby securely engage the collar against the support on an opposed side of the support from the tensioning mechanism. The tensioning mechanism includes a rigidly connected foot.Type: GrantFiled: September 18, 2017Date of Patent: April 23, 2019Inventor: Michael William Horton
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Publication number: 20180333061Abstract: Various embodiments of a neural monitoring device and related methods are disclosed herein. An exemplary neural monitoring device can be used during various surgical procedures to assess neural activity, status, health, etc. in order to anticipate and prevent nerve damage due to neural ischemia and other neural conditions. In some embodiments, a neural monitoring device can be configured to monitor neural activity, status, health, etc. of nerves encountered during a spinal surgical procedure. Embodiments of the neural monitoring device can also be used in non-spinal surgical procedures that can risk neural damage.Type: ApplicationFiled: April 30, 2018Publication date: November 22, 2018Inventors: John Pracyk, Thomas M. DiMauro, Michael J. O'Neil, William Horton, Emir Osmanagic, William Kane, John Wright, John Canady, Sean Lilienfeld
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Publication number: 20180267061Abstract: The present invention provides methods for determining bone growth velocity comprising: (a) measuring an amount of a collagen X marker in a sample obtained from a subject in need thereof; and (b) comparing the amount of collagen X marker measured in step (a) with a collagen X marker standard curve, wherein the amount of collagen X marker is measured using at least two reagents. In an embodiment, there is at least one capture reagent and at least one detection reagent. In a preferred embodiment for measuring CXM, the capture reagent is the aptamer SOMA1 and the detection reagent is the monoclonal antibody mAb X34. The present invention further provides methods for treating diseases, disorders or conditions comprising receiving an identification of an amount of CXM in a sample, wherein the amount of CXM has been identified using a combination of SOMA1 and mAb X34 as CXM-binding reagents, and administering a treatment in light of the amount of CXM in the sample.Type: ApplicationFiled: March 8, 2018Publication date: September 20, 2018Inventors: William A. Horton, Gregory P. Lunstrum, Ryan F. Coghlan, Jon A. Oberdorf
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Publication number: 20180079571Abstract: There is provided an adjustable fastening device configured to engage a support to provide a tether for the attachment of a tensioned line. The adjustable fastening device includes a plate, and an adjustable collar configured to extend around the support and securely engage with the plate in operation. There is also provided a tensioning mechanism configured to seat against the support and extend in length to drive the support and the plate apart in operation when the plate is securely engaged with the collar. In this way the plate is moved away from the support to thereby securely engage the collar against the support on an opposed side of the support from the tensioning mechanism. The tensioning mechanism includes a rigidly connected foot.Type: ApplicationFiled: September 18, 2017Publication date: March 22, 2018Inventor: Michael William Horton
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Publication number: 20180021032Abstract: The use of red or near infrared light upon neurons of the lumbar plexus that are in distress due to retraction-induced ischemia. The surgeon may protect nerves made ischemic in the surgery by: a) making an incision in a patient, b) inserting an access device into the patient through the incision to at least partially create a path to a spine of the patient, and c) irradiating nervous tissue adjacent the path with an amount of NIR or red light effective to provide neuroprotection.Type: ApplicationFiled: October 6, 2017Publication date: January 25, 2018Applicant: DEPUY SYNTHES PRODUCTS, INC.Inventors: Thomas M. DiMauro, William Horton
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Publication number: 20170042525Abstract: The use of red or near infrared light upon neurons of the lumbar plexus that are in distress due to retraction-induced ischemia. The surgeon may protect nerves made ischemic in the surgery by: a) making an incision in a patient, b) inserting an access device into the patient through the incision to at least partially create a path to a spine of the patient, and c) irradiating nervous tissue adjacent the path with an amount of NIR or red light effective to provide neuroprotection.Type: ApplicationFiled: October 31, 2016Publication date: February 16, 2017Inventors: Thomas M. DiMauro, William Horton
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Publication number: 20170020452Abstract: The use of red or near infrared light upon neurons of the lumbar plexus that are in distress due to retraction-induced ischemia. The surgeon may protect nerves made ischemic in the surgery by: a) making an incision in a patient, b) inserting an access device into the patient through the incision to at least partially create a path to a spine of the patient, and c) irradiating nervous tissue adjacent the path with an amount of NIR or red light effective to provide neuroprotection.Type: ApplicationFiled: October 6, 2016Publication date: January 26, 2017Applicant: DePuy Synthes Products, Inc.Inventors: Thomas M. DiMauro, William Horton
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Patent number: 9480855Abstract: The use of red or near infrared light upon neurons of the lumbar plexus that are in distress due to retraction-induced ischemia. The surgeon may protect nerves made ischemic in the surgery by: a) making an incision in a patient, b) inserting an access device into the patient through the incision to at least partially create a path to a spine of the patient, and c) irradiating nervous tissue adjacent the path with an amount of NIR or red light effective to provide neuroprotection.Type: GrantFiled: March 4, 2013Date of Patent: November 1, 2016Assignee: DePuy Synthes Products, Inc.Inventors: Thomas M DiMauro, William Horton
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Publication number: 20140088367Abstract: The use of red or near infrared light upon neurons of the lumbar plexus that are in distress due to retraction-induced ischemia. The surgeon may protect nerves made ischemic in the surgery by: a) making an incision in a patient, b) inserting an access device into the patient through the incision to at least partially create a path to a spine of the patient, and c) irradiating nervous tissue adjacent the path with an amount of NIR or red light effective to provide neuroprotection.Type: ApplicationFiled: March 4, 2013Publication date: March 27, 2014Inventors: Thomas M. DiMauro, William Horton
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Publication number: 20130311153Abstract: A method for sorting among a plurality of potential route plans for operating an autonomous ground based machine includes a step of creating a virtual model of a terrain of a work site. A first virtual lane having at least one measurable lane constraint is created within the virtual model. A first virtual machine footprint is created and has a first virtual movement profile corresponding to an actual autonomous movement profile of the autonomous machine. The first virtual machine footprint is moved from a starting position along the first virtual lane to an ending position according to the first virtual movement profile. During the moving step, the first virtual machine footprint is compared to the at least one measurable lane constraint. The first proposed route plan is then designated as either viable or unacceptable based on the comparison.Type: ApplicationFiled: May 15, 2012Publication date: November 21, 2013Applicant: CATERPILLAR INC.Inventors: Eric Alan Moughler, Craig Lawrence Koehrsen, Douglas William Horton
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Patent number: 8426396Abstract: The present application provides, inter alia, methods of treating disorders mediated by FGFRs and methods of screening for Hsp90 inhibitor compounds.Type: GrantFiled: January 8, 2009Date of Patent: April 23, 2013Assignee: Shriners Hospitals for ChildrenInventors: William A. Horton, Melanie B. Laederich
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Publication number: 20090192133Abstract: The present application provides, inter alia, methods of treating disorders mediated by FGFRs and methods of screening for Hsp90 inhibitor compounds.Type: ApplicationFiled: January 8, 2009Publication date: July 30, 2009Inventors: William A. Horton, Melanie B. Laederich
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Patent number: 7434878Abstract: A juvenile vehicle seat includes a seat bottom, a seat back, a pivotable shield, and a juvenile-restraint harness. The shield includes a barrier coupled to the juvenile-restraint harness.Type: GrantFiled: October 7, 2005Date of Patent: October 14, 2008Assignee: Cosco Management, Inc.Inventors: James M. Kain, Jason A. Crowell, William Horton, Steven Oltman