Abstract: A wand and hose assembly for a vacuum cleaner includes a suction wand fluidly connected to the end of a suction hose by a duct and the duct incorporates an articulating joint for allowing articulated movement of the suction wand relative to the end of the suction hose. The wand and the duct are arranged for telescopic sliding movement relative to one another, and the articulating joint is moveable into a position in which the wand can slide telescopically through the duct for retraction into the suction hose.

Abstract: Systems and methods of threading a metal substrate on a rolling mill include receiving a coil of the metal substrate. The method also includes uncoiling the metal substrate from the coil while the coil and guiding the metal substrate to a work stand of the rolling mill with a threading system.

Abstract: A spreader includes a frame having wheels mounted on an axle. A gear assembly on the axle is coupled with a shaft. A hopper is mounted on the frame and holds particulate that empties through an opening within the bottom wall. An impeller is mounted on the shaft and receives the particulate emptied from the hopper. A controlled-release assembly is mounted about the shaft and includes a drive housing secured to the hopper. The drive housing has a funnel opening to dispense the particulate therethrough. A transfer wheel within the drive housing is rotatably coupled to the shaft. When the shaft is rotating, the transfer wheel rotates whereby the particulate is delivered to the funnel. When the shaft is stationary, the transfer wheel is stationary whereby particulate is not delivered to the funnel.

Abstract: The invention relates to antibody molecules and antigen-binding portions thereof which bind specifically to glucocorticoid-induced TNF receptor (GITR). In particular aspects of the invention, the antibody molecules specifically bind to human GITR and cynomolgus monkey GITR. The anti-GITR antibody molecules of the invention have been developed and optimized using CDR sequences derived from a murine anti-GITR antibody 6C8. Medical uses of the antibody molecules are disclosed.

Abstract: An apparatus includes a first member coupled to a second member. The first member defines a chamber containing a dry powder and includes a chamber wall that forms an outer boundary of the chamber. The second member includes a surface covering the chamber and defines an intake channel and an exit channel. The exit channel is fluidically coupled to the chamber via an exit opening. The intake channel is fluidically coupled to the chamber via an intake port. A center line of the intake channel is tangential to a portion of the chamber wall such that a portion of an inlet airflow conveyed into the chamber via the intake channel has a rotational motion. The intake port is defined at least in part by an intake ramp. The intake ramp includes a transition surface that forms an exit angle with respect to the surface of less than 105 degrees.

Abstract: An on-car brake lathe is provided with a runout compensation system configured to monitor the rotational position of a pair of slant discs within an aligning joint of the on-car brake lathe. The system monitors the amount of runout present between the rotating components of the on-car brake lathe and the wheel hub to which the on-car brake lathe is secured. The system calculates the appropriate rotational position for each slant disc within the aligning joint required to impart a necessary adjustment in the wheel coupling rotational axis in order to align the on-car brake lathe with the rotational axis of the wheel hub. Finally, an adjustment mechanism is activated to rotationally drive each slant disc directly to the calculated rotational position with a minimum amount of rotational movement based on the current rotational position of each slant disc and the required calculated rotational positions.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: A demountable wall system includes a frame component. The frame component may include a front channel that receives a panel of the demountable wall system. In addition to the front channel, the frame component may include at least one of a front cover, a removable back cover, a leveling system, a supplemental channel, or a joining system. In some examples, the demountable wall system includes a door support system for movably supporting a door relative to the panel of the demountable wall system.

Abstract: The present disclosure provides a variant tyrosine hydroxylase that provides for increased production of L-DOPA in a host cell that expresses the tyrosine hydroxylase. The present disclosure provides nucleic acids encoding the variant tyrosine hydroxylase, and host cells genetically modified with the nucleic acids. The present disclosure provides methods of making L-DOPA in a host cell. The present disclosure provides methods of making a benzylisoquinoline alkaloid (BIA), or a BIA precursor. The present disclosure provides methods of detecting L-DOPA level in a cell. The present disclosure provides methods of identifying tyrosine hydroxylase variants that provide for increased L-DOPA production; and methods of identifying gene products that provide for increased tyrosine production.

Abstract: A method and apparatus for folding a case along a hinge where the hinge is designed to project the neutral bend access of the fold to a layer affixed to an outer surface of the case.

Abstract: Pressure-sensing touch systems and methods are disclosed for sensing the occurrence of a touch event based on pressure applied at a touch location. The touch system includes a light-source system and a detector system operably adjacent respective input and output edges of a waveguide. Pressure at a touch location on the waveguide gives rise to a touch event causes the waveguide to bend or flex. The waveguide bending causes a change in the optical paths of light traveling by FTIR, causing the light distribution in the output light to change. The changes are detected and are used to determine whether a touch event occurred, as well as the time-evolution of the touch event. The changes in the output light can include polarization changes caused by birefringence induced in the waveguide by the applied pressure applied. Various detector configurations are disclosed for sensing the location and pressure of a touch event.

Abstract: The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.

Abstract: The present invention relates generally to the generation of bio-products from organic matter feedstocks. More specifically, the present invention relates to the use of pulping liquors in the hydrothermal/thermochemical conversion of lignocellulosic and/or fossilised organic feedstocks into biofuels (e.g. bio-oils) and/or chemical products (e.g. platform chemicals).

Abstract: A system and method for coordinating security components, including: determining, by an application executing on a client device, a need to perform a sharable functional task; identifying a first security component and a second security component installed on the client device and capable of performing variations of the sharable functional task, where variations of the sharable functional task are functionally overlapping and not identical; identifying a set of characteristics characterizing the first security component and the second security component; selecting the second security component as a primary security component for performing a variation of the sharable functional task based on the set of characteristics; delegating, by one or more processors, performance of the sharable functional task to the primary security component; and instructing the processors to cause functionality associated with the first security component to be at least partially suspended.

Abstract: Methods and systems are provided for diagnosing an engine thermal encapsulation positioned around a powertrain of a vehicle. In one example, degradation of the thermal encapsulation may be determined by comparing a temperature sampled via a sensor during engine off condition with an expected temperature.

Abstract: The smart HVAC manifold system for servicing air conditioning systems is designed to dynamically manage the data acquisition process and to measure and calculate the performance indicators and output as the load conditions and or equipment operation change taking into account variables in the installation that can impact performance. Both visually and by a very specific data set the performance of the equipment and the installation can quickly be assessed and specific problems identified along with suggestions of typical faults or problems that may need addressed by the technician. The smart HVAC manifold system provides a means of quickly and electronically handling the manual data acquisition process which would include component and or system model and serial numbers, equipment location (GPS tagging), customer name, environmental conditions that effect performance and performance measurement (weather data and elevation), and supports photo, voice and text documentation.

Abstract: A dead front connector including an electrical coupling, a voltage tap, a voltage testing circuit. The electrical coupling is configured to electrically connect a power cable to a device. The voltage tap is configured to allow testing for the presence of a voltage between the power cable and the device. The voltage testing circuit is placed within the voltage tap. The voltage testing circuit includes an indicator configured to provide an indication when the voltage is present.

Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.