Patents by Inventor William A. L. Heaton

William A. L. Heaton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets
    Patent number: 5487971
    Abstract: The invention is a sterile, plasma-free storage medium for blood components including red blood cells and for platelets processed separately or together. The red cell storage medium includes adenine and a physiologically compatible, aqueous electrolyte solution. In one liter of this electrolyte solution there is between about 3.0 grams and about 25.0 grams of dextrose, between about 3.0 grams and about 6.0 grams of sodium citrate, and between about 2.0 grams and about 4.2 grams of sodium bicarbonate. The red cell storage medium is isotonic and has a pH in a range of between about 6.8 and about 7.4. The red cell storage medium is capable of storing and preserving red cells for at least 49 days.
    Type: Grant
    Filed: September 28, 1993
    Date of Patent: January 30, 1996
    Assignee: American National Red Cross
    Inventors: Stein Holme, William A. L. Heaton
  • Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets
    Patent number: 5248506
    Abstract: The invention is a sterile, plasma-free storage medium for blood components including red blood cells and for platelets processed separately or together. The red cell storage medium includes a physiologically compatible, aqueous electrolyte solution. In one liter of this electrolyte solution there is between about 3.0 grams and about 25.0 grams of dextrose, between about 3.0 grams and about 6.0 grams of sodium citrate, and between about 2.0 grams and about 4.2 grams of sodium bicarbonate. The red cell storage medium is isotonic and has a pH in a range of between about 6.8 and about 7.4. The red cell storage medium is capable of storing and preserving red cells for at least 49 days.
    Type: Grant
    Filed: October 5, 1990
    Date of Patent: September 28, 1993
    Assignee: American National Red Cross
    Inventors: Stein Holme, William A. L. Heaton
  • Extended shelf life platelet preparations and process for preparing the same
    Patent number: 4994367
    Abstract: A first aspect of the present invention is a blood platelet preparation comprising blood platelets, an adenylate cyclase stimulator, a phosphodiesterase inhibitor, a thrombin inhibitor, and a plasmin inhibitor. A second aspect of the present invention is a plasma-free platelet storage medium containing dextrose, sodium citrate, sodium bicarbonate, and a platelet activation inhibitor, with a preferred platelet activation inhibitor comprising an adenylate cyclase stimulator in combination with a phosphodiesterase inhibitor. A third aspect of the present invention is a process for producing a plasma-free platelet preparation comprising producing platelet-rich plasma (PRP) from whole blood, adding a platelet activation inhibitor thereto, centrifuging the PRP to deposit the platelets on the bottom of the centrifuge container, removing the platelet-free plasma supernatant therefrom and adding a plasma-free liquid platelet storage medium thereto.
    Type: Grant
    Filed: October 7, 1988
    Date of Patent: February 19, 1991
    Assignee: East Carolina University
    Inventors: Arthur P. Bode, William A. L. Heaton, Stein Holme, David T. Miller
  • Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets
    Patent number: 4961928
    Abstract: The invention is a sterile, plasma-free storage medium for blood components including red blood cells and for platelets processed separately or together. The red cell storage medium includes a physiologically compatible, aqueous electrolyte solution. In one liter of this electrolyte solution there is between about 3.0 grams and about 25.0 grams of dextrose, between about 3.0 grams and about 6.0 grams of sodium citrate, and between about 2.0 grams and about 4.2 grams of sodium bicarbonate. The red cell storage medium is isotonic and has a pH in a range of between about 6.8 and about 7.4. The red cell storage medium is capable of storing and preserving red cells for at least 49 days. The medium can also contain adenine.
    Type: Grant
    Filed: September 21, 1987
    Date of Patent: October 9, 1990
    Assignee: American Red Cross
    Inventors: Stein Holme, William A. L. Heaton