Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

Abstract: A portable jump starter and air compressor device, including a jump starter, air compressor, and/or vacuum cleaner. One or more of the jump starter, air compressor, and/or vacuum cleaner are powered a same or different one or more rechargeable batteries (e.g. one or more Li-ion batteries). The air compressor, for example, includes a piston/valve arrangement configured to allow a piston of the piston/valve arrangement to move in close proximity to a cylinder head of the cylinder of the air compressor.

Abstract: Disclosed is a robot apparatus with a capable and highly maneuverable drive system incorporating two differential swerve drive pods. The robot apparatus further includes a claw mechanism for grasping an object, a passthrough mechanism for moving the object horizontally and a lift mechanism for moving the object vertically. The robot apparatus allows for rapid manipulation and movement of objects such as cones.

Abstract: A hierarchical network enables access for a stacked memory system including or more memory dies that each include multiple memory tiles. The processor die includes multiple processing tiles that are stacked with the one or more memory die. The memory tiles that are vertically aligned with a processing tile are directly coupled to the processing tile and comprise the local memory block for the processing tile. The hierarchical network provides access paths for each processing tile to access the processing tile's local memory block, the local memory block coupled to a different processing tile within the same processing die, memory tiles in a different die stack, and memory tiles in a different device. The ratio of memory bandwidth (byte) to floating-point operation (B:F) may improve 50× for accessing the local memory block compared with conventional memory. Additionally, the energy consumed to transfer each bit may be reduced by 10×.

Abstract: An intelligent item receptacle, system, and method for providing supplemental media content in response to depositing an item having media indicia disposed thereon. An intelligent item receptacle includes an item receptacle securely enclosing an interior volume, an item sensor configured to detect an inserted item, a camera within the interior volume configured to capture an image of the item, and an output configured to play audio or visual content to bystanders outside the item receptacle. Processing circuitry within the item receptacle analyzes the image to determine if the media indicia are present on the item and, if present, causes the output to play the audio or visual content associated with the media indicia.

Abstract: Systems and methods for phenotyping clinical data are provided. The method includes obtaining episodic records comprising unstructured clinical data from an electronic medical record (EMR) or electronic health record (EHR) for patients. The method also includes filtering the episodic records by language pattern recognition to identify episodic records that each includes an expression related to a clinical condition. The method also includes splitting each episodic record to obtain snippets comprising tokens. The method also includes predicting if an episodic record represents an instance of the clinical condition using a trained classifier. The trained classifier includes an aggregation function that aggregates the snippets to output a corresponding representation for the episodic record, and an interpretation function that interprets the corresponding representation to output a corresponding prediction for whether the episodic record represents an instance of the clinical condition.

Abstract: A multi-component storage system is provided. The storage system includes a primary storage component and a secondary storage component. The primary storage component includes a body surrounding a storage area, the body having a plurality of support ribs extending therefrom, the plurality of support ribs including at least one pair of support ribs on opposing sides of the body. The primary storage component includes at least one open side. The secondary storage component is configured to be inserted within the storage area of the primary storage component through the at least one open side and aligned with the at least one pair of support ribs.

Abstract: A dispensing system for a floor treatment composition. The dispensing system includes a housing partially enclosing a cavity and a cradle moveable within the housing along a z-axis from a first position to a second position. The dispensing system further includes a chassis and a sliding lock that includes an open frame. An inlet canula projects through the open frame. When the cradle is in the second position, the inlet canula entrance projects through the open frame and through a liquid transport aperture in the cradle. Latches extending from the open frame also project through engagement apertures in the cradle when the cradle is in the second position. The dispensing system further includes a pump in fluid communication with the inlet canula and a mop head in fluid communication with the pump.

Abstract: A dispensing package for a floor treatment composition. The dispensing package includes a coupling shell and a container. The coupling shell is provided with a dispensing opening and at least one front aperture. The container includes a membrane seal engaged with a sealing surface of the container. The coupling shell can provide for a connection between a container and a dispensing system.

Abstract: A method of engaging a dispensing package with a dispensing system. The dispensing system includes a cradle movable from a first position to a second position. The dispensing system also includes a sliding lock that includes an open frame and a plurality of latches extending from the open frame. An inlet canula protrudes through the cradle when the cradle is in the second position. The dispensing package includes a coupling shell. The coupling shell includes a front aperture in the top wall thereof. The dispensing package is fitted to the cradle which is in the first position and pushed downwardly. The inlet canula punctures the membrane seal of the and the latch engages with the front aperture hold the dispensing package in the dispensing system.

Abstract: A coupling shell including a top wall, a shell wall, a front aperture in the top wall, a dispensing opening in the top wall, and a neck fitment projecting into the shell interior of the shell wall. The coupling shell can provide for a connection between a container and a dispensing system.

Abstract: A multispectral imaging device and system is provided. The multispectral imaging device includes a light emitting diode (LED) array including a plurality of LEDs configured to sequentially emit light towards a target object to be scanned, each of the LEDs being configured to emit a differing wavelength from one another; a scanning hood configured to house the LED array; a luminosity sensor configured to capture luminosity data of each light emitted by the plurality of LEDs and reflected from the target object; a printed circuit board (PCB) configured to provide electronic connections and mounting surfaces for the LED array and the luminosity sensor; a housing configured encase the PCB; and a trigger configured to initiate operation of the LED array.

Abstract: Systems and methods for generating a video of a user-defined virtual reality scene are disclosed. Exemplary implementations may: obtain a scene definition; obtain camera information for multiple virtual cameras to be used in generating a two-dimensional presentation of the virtual reality scene; execute a simulation of the virtual reality scene from the scene definition for at least a portion of the scene duration; obtain camera timing instructions specifying which of the virtual cameras should be used to generate the two-dimensional presentation of the virtual reality scene as a function of progress through the scene duration; generate the two-dimensional presentation of the virtual reality scene in accordance with the camera timing instructions and the camera information.

Abstract: A crop prediction system performs various machine learning operations to predict crop production and to identify a set of farming operations that, if performed, optimize crop production. The crop prediction system uses crop prediction models trained using various machine learning operations based on geographic and agronomic information. Responsive to receiving a request from a grower, the crop prediction system can access information representation of a portion of land corresponding to the request, such as the location of the land and corresponding weather conditions and soil composition. The crop prediction system applies one or more crop prediction models to the access information to predict a crop production and identify an optimized set of farming operations for the grower to perform.

Abstract: The present disclosure relates to a passivating contact that includes a dielectric layer constructed of a first material, an intervening layer constructed of a second material, and a substrate constructed of a semiconductor, where the dielectric layer is positioned between the substrate and the intervening layer, the dielectric layer has a first thickness, and the substrate has a second thickness. The passivating contact also includes a plurality of conductive pathways that include the second material and pass through the first thickness, the second material penetrates into the second thickness forming a plurality of penetrating regions within the substrate, and the plurality of conductive pathways are configured to allow current to pass through the first thickness.

Abstract: Apparatuses, methods, and systems are disclosed for accelerated ergonomic collection of capillary blood. An apparatus and system include a blood collection module with a proximal portion including a vacuum generation chamber, a distal portion including a blood collection chamber, a concave mid portion including a pressure equalization channel configured to equalize reduced air pressure. The apparatus further includes a sealing surface to stably seal the blood collection module to the skin around a collection site and a slide latch actuated by a lengthwise sliding motion. Also included is a lancet carrier with linearly-arranged lancet strips to puncture rows of blood extraction slits in the collection site. The apparatus also includes an angled transfer port with a low-resistance non-microfluidic blood flow channel to a transfer module, then to a plasma separation module with a multilayer laminate and plasma separation membrane. Methods for accelerated ergonomic collection of capillary blood are disclosed.

Abstract: Aspects described herein may relate to a transaction exchange platform using a streaming data platform (SDP) and microservices to process transactions according to review and approval workflows. The transaction exchange platform may receive transactions from origination sources, which may be added to the SDP as transaction objects. Microservices on the transaction exchange platform may interact with the transaction objects based on configured workflows associated with the transactions. Processing on the transaction exchange platform may facilitate clearing and settlement of transactions. Some aspects may provide for dynamic and flexible reconfiguration of workflows and/or microservices. Other aspects may provide for data snapshots and workflow tracking, allowing for monitoring, quality control, and auditability of transactions on the transaction exchange platform.

Abstract: Various embodiments are directed to processing and executing digital asset transfers between two users. An example method includes receiving a data object defining a digital asset transfer, and the data object may be a query from the first user to initiate an outbound transfer to a second user or an approval of a request for digital asset units from the second user. The method further includes retrieving account balance data objects associated with the digital asset accounts for the first and second users. The method further includes, responsive to determining that the digital asset transfer satisfies one or more transfer conditions, executing the digital asset transfer by executing a closed-loop debit from the first user and executing a closed-loop credit to the second user. The method further includes updating the account balance data object to reflect the resulting balances of each digital asset account.

Abstract: In some embodiments, a hand controller apparatus for controlling a tool in a robotic surgery system can include a body with a proximal end and a distally located interface end configured to be coupled to an input apparatus configured to control the tool. The hand controller apparatus can also include a control lever attached to a pivot joint proximate a side surface of the body and extending along the body and away from the proximal end, the control lever being laterally moveable relative to the side surface of the body about the pivot joint. The hand controller apparatus can additionally include a lateral movement detector configured to magnetically or inductively detect a lateral movement of the control lever.

Abstract: An oximetry device sealed in a sheath directs a user to allow the oximetry device to make oximetry measurements at a number of different tissue locations of a patient and average two or more of the oximetry measurements by directing the lifts and placements of the oximetry device and sheath to and from the different tissue locations and detecting the lift and placements. The averages are generated and displayed on a display of the device for the oximetry measurements if the lifts are made while use directions for the lifts are displayed on a display of the oximetry device. The averages are not generated if the lifts are not made while the user directions for the lifts are not displayed. The averages are simultaneously displayed with the oximetry measurements which are instantaneous measurement for patient tissue.