Abstract: In one aspect, a drug delivery device is provided herein including: a monolithic body having a plurality of fluid ducts and at least one outlet duct formed therein; a plurality of drug cartridges attached to the body, the drug cartridges each including a reservoir for accommodating at least one drug wherein, the plurality of fluid ducts is arranged to convey the drugs from the drug cartridges to the at least one outlet duct; and, a needle support spaced from the body, the needle support including a needle configured for insertion into a patient for drug delivery, the needle support including adhesive for releasable securement to a patient, wherein, the needle support is connected to the body by a flexible tether through which passes at least one fluid passageway formed to convey drug from the at least one outlet duct to the needle.

Abstract: A system collects a plurality of drill cuttings from a subsurface of a geothermal borehole while drilling the borehole. The system obtains a plurality of thermal conductivity values for the plurality of drill cuttings. The system determines, using the plurality of thermal conductivity values, thermal performance data of the geothermal borehole. In accordance with a determination that the thermal performance data of the geothermal borehole meets or exceeds a threshold value, the system updates, according to the thermal performance data, one or more drilling parameters to one or more updated drilling parameters and controls the drilling of the geothermal borehole according to the one or more updated drilling parameters.

Abstract: A system for constructing geothermal fields includes a coiled tubing (CT) string, a power source, and an electrically activated bottomhole assembly (BHA) coupled to the CT string. The electrically activated BHA includes an electric motor and a drill bit. The system includes one or more processors and memory. The memory stores instructions that, when executed by the one or more processors, cause the system to deploy the CT string from a surface into a subsurface for drilling a geothermal borehole, and cause the system to, during the drilling, (i) transfer power from the power source to the electric motor via at least a first portion of the CT string and (ii) transfer electrical current from the electric motor to the electric power source via an electrical conductor that is different from the at least the first portion of the CT string.

Abstract: There is described an outlet valve for a container, for example, a bioreactor container. The outlet valve comprises a membrane and the outlet valve is attachable to a wall of the container such that the membrane is arranged to face an internal volume of the container. The outlet valve further comprises an actuator operable to move membrane from: a first position in which the membrane is substantially in a plane of the wall of the container, to a second position in which a part of the membrane is displaced from the plane of the wall of the container such that the membrane is frustum-shaped.

Abstract: The present invention provides methods and system for power generation using a high efficiency combustor in combination with a CO2 circulating fluid. The methods and systems advantageously can make use of a low pressure ratio power turbine and an economizer heat exchanger in specific embodiments. Additional low grade heat from an external source can be used to provide part of an amount of heat needed for heating the recycle CO2 circulating fluid. Fuel derived CO2 can be captured and delivered at pipeline pressure. Other impurities can be captured.

Abstract: There is provided a rectifier of an alternating input current, which may comprise: an electrical switch comprising a length of HITS material to carry an alternating switch current, the HITS material having a critical current: a magnetic field generator to apply a magnetic field to the HTS material: a control mechanism to control the magnetic field generator to switch the switch between a low-resistance state when a magnitude of the magnetic field is relatively low and a higher-resistance state when a magnitude of the magnetic field is relatively high, the relatively high magnitude being sufficient to reduce the critical current so that, for a part of the alternating switch current cycle, the current approaches the critical current, is substantially equal to the critical current or is greater than the critical current. There is further provided an electrical switch having two strands of superconducting material arranged in a bifilar arrangement.

Abstract: A clot removal system comprises a catheter, a vacuum source, and a controller. The catheter comprises a proximal end, a distal end, and controller operating parameters and defines a lumen configured to be filled with a liquid column having a proximal portion. The vacuum source is configured to supply vacuum. The controller is configured to carry out a control pattern of turning on and off the vacuum based upon the controller operating parameters and is configured to receive the controller operating parameters in an automatic response to the catheter being operatively connected to at least one of the vacuum source and the controller and, responsive to the connection, to carry out the control pattern to change a level of vacuum at the distal end of the catheter.

Abstract: Arthrodesis devices and arthrodesis procedures are disclosed herein. In an embodiment, an arthrodesis device includes a shape memory material connecting member attached to two points of fixation.

Abstract: A bioreactor interface plate assembly for attachment to a bioreactor container holding a cell suspension. The bioreactor interface plate assembly comprising a bioreactor interface plate and a filter. The bioreactor interface plate including a port formed therein for egress of fluid from the bioreactor container. The filter attached to the bioreactor interface plate in fluid communication with the port, the filter positioned to be located within an internal volume of the bioreactor container while the bioreactor container is connected to the bioreactor interface plate. The filter configured to retain cells from the cell suspension in the internal volume when the fluid egresses from the bioreactor container via the port.

Abstract: A clot removal system comprises a catheter, a vacuum source, and a controller. The catheter comprises a proximal end, a distal end, and controller operating parameters and defines a lumen configured to be filled with a liquid column having a proximal portion. The vacuum source is configured to supply vacuum. The controller is configured to carry out a control pattern of turning on and off the vacuum based upon the controller operating parameters and is configured to receive the controller operating parameters in an automatic response to the catheter being operatively connected to at least one of the vacuum source and the controller and, responsive to the connection, to carry out the control pattern to change a level of vacuum at the distal end of the catheter.

Abstract: A mounting system including inner and outer structures, a mount fixture, a securing plate, and a securing key is disclosed. The inner structure includes an annulus encircled by an engagement groove. The outer structure includes an annular surface having a grooved slot. The annular surface contours about the inner structure annulus. The mount fixture includes a passage and a receiving opening. The securing plate abuts the mount fixture and includes a receiving slot having locking and unlocked portions. The securing key includes a prong, a stopper prong, a stopping structure, and a locking groove. The prong extends through the passage and the slot unlocked portion, while also passing along the grooved slot and abutting the engagement groove. The securing key stopping structure abuts the mount fixture and the locking groove fits within the locking portion. The stopper prong extends into the receiving opening and abuts the engagement groove.

Abstract: A mounting system is disclosed. The mounting system includes an inner structure, an outer structure, a mount fixture, a securing plate, and a securing key. The inner structure includes a central annulus encircled by an engagement groove. The outer structure includes an annular surface having a grooved slot. The annular surface contours about the inner structure central annulus. The mount fixture includes a passage. The securing plate abuts the mount fixture and includes a receiving slot having locking and unlocked portions. The securing key includes a prong having a stopping structure and a locking groove. The prong extends through the mount fixture passage and the securing plate slot unlocked portion, while also passing along the annular surface grooved slot and abutting the central annulus engagement groove. The securing key stopping structure abuts the mount fixture and the securing key locking groove fits within the securing plate slot locking portion.

Abstract: An aspiration thrombectomy system includes a thrombectomy catheter assembly that maintains pulsatile energy of cyclic aspiration while the catheter is occluded. A system configuration includes a catheter, vacuum and vent fluid sources respectively connected to vacuum and vent valves, a vent catheter valve connecting a catheter lumen to the vent fluid source, a manifold connected to the catheter and vacuum and vent valves, a pressure sensor upstream of the vacuum valve, and a controller configured to operate the vacuum, vent, and vent catheter valves, receive sensor pressure data, control the vent catheter valve dependent upon the data. Determination can be upon decrease of pressure waveform amplitude. An operable lumen of the system includes a volume of the catheter lumen and an interior of the manifold up to an input of the vacuum valve input and an output of the vent valve.

Abstract: The present invention relates to, in a first aspect a handheld modular spectrometer comprising at least a light source, a detector, a sampling means and a processing unit, wherein at least the processing unit is within a spectrometer body that further comprises a connection node, at least the sampling means is within a spectrometer head module that attaches to the spectrometer body, the spectrometer head module further comprises a node interfacing means that interfaces with the connection node upon attachment of the spectrometer head module to the spectrometer body, and the attached spectrometer head module is able to be detached from the spectrometer body, enabling attachment of an alternate spectrometer head module also having a sampling means and node interfacing means, so as to alter at least one functional property of the handheld modular spectrometer.