Abstract: A human CD40L-specific Tn3 molecule and therapeutic uses thereof.

Abstract: Provided are compositions and methods comprising a CD40L-specific Tn3 scaffold. Also provided are methods of utilizing the same for the prevention and treatment of Sjögren's Syndrome.

Abstract: A human CD40L-specific Tn3 molecule and therapeutic uses thereof for the treatment of autoimmune disease (e.g., rheumatoid arthritis).

Abstract: The present disclosure is related to methods of treating an autoimmune disorder in a subject in need thereof comprising administering an immunoglobulin-like transcript 7 (ILT7) binding protein. The present disclosure also relates to methods of reducing plasmacytoid dendritic cells (pDCs), or reducing a type I interferon gene signature (IFNGS) in a tissue, of a subject in need thereof by administering an ILT7-binding protein to the subject.

Abstract: A human CD40L-specific Tn3 molecule and therapeutic uses thereof for the treatment of lupus nephritis are provided herein. Also provided are therapeutic regimens that comprise a CD40L-specific Tn3 scaffold.

Abstract: Methods for using an anti-CD19 antibody to treat autoimmune disease are disclosed herein. In particular the use of VIB551, a humanised, affinity-optimised, afucosylated IgG1 kappa monoclonal antibody to treat Neuromyelitis optica spectrum disorder.

Abstract: A sensor apparatus may include a conduit structure including an inner surface defining a conduit extending through an interior of the conduit structure, an inlet structure coupled to an end of the conduit structure, and a plurality of sensor devices in hydrodynamic contact with the conduit. The inlet structure may couple with an outlet end of an external tobacco element to hold the outlet end of the external tobacco element in fluid communication with an inlet opening of the conduit structure, such that the conduit structure may receive a generated aerosol from the external tobacco element at the inlet opening, and draw an instance of aerosol through the conduit towards an outlet opening. The instance of aerosol may include at least a portion of the generated aerosol. Each sensor device may generate sensor data indicating a pressure of the instance of aerosol through a separate portion of the conduit.

Abstract: A sensor apparatus may include a conduit structure including an inner surface defining a conduit extending through an interior of the conduit structure, an inlet structure coupled to an end of the conduit structure, and a plurality of sensor devices in hydrodynamic contact with the conduit. The inlet structure may couple with an outlet end of an external tobacco element to hold the outlet end of the external tobacco element in fluid communication with an inlet opening of the conduit structure, such that the conduit structure may receive a generated aerosol from the external tobacco element at the inlet opening, and draw an instance of aerosol through the conduit towards an outlet opening. The instance of aerosol may include at least a portion of the generated aerosol. Each sensor device may generate sensor data indicating a pressure of the instance of aerosol through a separate portion of the conduit.