Patents by Inventor William A. Remers
William A. Remers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20030129222Abstract: Disclosed are novel compositions comprising a lipid and imexon or a derivative thereof. Also disclosed are liposomal compositions comprising imexon or a derivative thereof. Methods for administrating pharmaceutically acceptable compositions comprising a lipid and imexon or a derivative thereof for the treatment of diseases, such as cancer, are also disclosed herein.Type: ApplicationFiled: November 20, 2001Publication date: July 10, 2003Inventors: Gabriel Lopez-Berestein, William A. Remers, Evan Hersh
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Patent number: 6476236Abstract: The present invention provides a process for producing an aziridine-1-carboxamide of the formula: from an aziridine of the formula: and an isocyanate of the formula R5—N═C═O, where R1, R2, R3, R4 and R5 are those defined herein. In addition, the present invention also provides a process for producing a 4-imino-1,3-diazabicyclo[3.1.0]-hexan-2-one of the formula: from the aziridine-1-carboxamide of Formula I.Type: GrantFiled: November 26, 2001Date of Patent: November 5, 2002Assignee: The Arizona Board of RegentsInventors: William Remers, Bashyam Iyengar
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Patent number: 6297230Abstract: The present invention is directed to novel anti-cancer compounds of the formula. wherein X is CN, R4 is hydrogen or lower alkyl; and R5 is lower alkyl, lower cycloalkyl, alkenyl, alkynyl, aryl, monosubstituted aryl, disubstituted aryl, aryl lower alkyl, lower alkoxycarbonyl lower alkyl, or heterocyclic ring, with the proviso that when X is CN, and R4 is hydrogen, then R5 is not CH3, C6H5, or, p-nitrophenyl. R4, R5 and N taken together form a heterocyclic ring.Type: GrantFiled: April 10, 2000Date of Patent: October 2, 2001Assignee: Amplimed, Inc.Inventors: William A. Remers, Evan M. Hersh, Robert T. Dorr, Bhashyam Iyengar
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Patent number: 5635506Abstract: This invention relates to a compound useful for the treatment of tumors having the formula: ##STR1##Type: GrantFiled: November 18, 1993Date of Patent: June 3, 1997Assignee: Research Corporation Technologies, Inc.Inventors: David S. Alberts, Robert T. Dorr, William A. Remers, Salah M. Sami
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Patent number: 5098926Abstract: Novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula IV, ##STR1## wherein: Y is hydrogen or lower alkyl; and X is a radical of the formula --O--R, wherein R is:a substituted lower alkyl radical selected from the group consisting of mono- and di-hydroxy lower alkyl, cyano lower alkyl, halo lower alkyl, lower alkyl amino lower alkyl, hydroxy lower alkylthio lower alkyl, hydroxy lower alkyldithio lower alkyl, di-lower alkoxy lower alkyl, hydroxy or lower alkoxy substituted lower alkoxy lower alkyl, cyclo lower alkyl substituted lower alkyl; and lower alkyl substituted dioxolanyl lower alkyl ora lower alkenyl radical; ora lower alkynyl radical; ortetrahydro furanyl or a lower alkyl substituted derivative thereof, oxiranyl lower alkyl, tetrahydropyranyl lower alkyl, or furanyl lower alkyl.Type: GrantFiled: December 13, 1989Date of Patent: March 24, 1992Assignee: University Patents, Inc.Inventors: William A. Remers, Salah M. Sami
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Patent number: 4888341Abstract: Novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula IV, ##STR1## wherein: Y is hydrogen or lower alkyl; and Z is a radical of the formula --O--R, wherein R is:a substituted lower alkyl radical selected from the group consisting of mono- and di-hydroxy lower alkyl, cyano lower alkyl, halo lower alkyl, lower alkyl amino lower alkyl, hydroxy lower alkylthio lower alkyl, hydroxy lower alkyldithio lower alkyl, di-lower alkoxy lower alkyl, hydroxy or lower alkoxy substituted lower alkoxy lower alkyl, and cyclo lower alkyl substituted lower alkyl; ora lower alkenyl radical; ora lower alkynyl radical; ora substituted or unsubstituted oxygen-containing heterocyclic radical selected from the group consisting of tetrahydro furanyl or lower alkyl substituted derivatives thereof, lower alkyl substituted oxiranyl, lower alkyl substituted dioxolanyl, lower alkyl substituted pyranyl, or lower alkyl substituteType: GrantFiled: September 4, 1984Date of Patent: December 19, 1989Assignee: University Patents, Inc.Inventors: William A. Remers, Salah M. Sami
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Patent number: 4885304Abstract: Compounds of the formula, I, ##STR1## wherein: Y is hydrogen or lower alkyl; and X is a thiazolamino radical, a furfurylamino radical or a radical of the formula, ##STR2## in which R, R.sup.1, and R.sup.2 are the same or different and selected from the group consisting of hydrogen and lower alkyl, and R.sup.3 is selected from the group consisting of lower alkenyl, halo-lower alkenyl, lower alkynyl, lower akloxycarbonyl, thienyl, formamyl, tetrahydrofuryl and benzene sulfonamide.Also disclosed are novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula, Ia, ##STR3## wherein, Y is hydrogen or lower alkyl; and Z is a thiazolamino radical, a furfuryllamino radical, a cyclopropylamino radical, a pyridylamino radical, or a radical of the formula, ##STR4## in which R.sup.4, R.sup.5, and R.sup.6 are the same or different and selected from the group consisting of hydrogen and lower alkyl, and R.sup.Type: GrantFiled: July 11, 1984Date of Patent: December 5, 1989Assignee: University Patents, Inc.Inventor: William A. Remers
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Patent number: 4746746Abstract: Novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula IIIa, ##STR1## wherein: Y is hydrogen or lower alkyl; and Z is an hydroxy substitited 1-pyrrolidinyl radical, ora lower alkyl substituted piperidyl radical, ora 1-piperazinyl radical or an acetamino, acetyl, carbamido, cyano, carboxy lower alkylamino, di-lower alkoxy, nitro, sulfamyl, or lower alkyl substituted anilino radical, ora radical of the formula, ##STR2## wherein R is hydrogen or lower alkyl and R.sup.1 is a nitrogen containing heterocyclic radical selected from the group consisting of amino substituted triazolyl, lower alkyl substituted isothiazolyl, benzothiazolyl, and nitro and halo substituted derivatives of benzothiazolyl, or R.sup.Type: GrantFiled: July 22, 1985Date of Patent: May 24, 1988Assignee: University Patents, Inc.Inventor: William A. Remers
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Patent number: 4617389Abstract: Antineoplastic compounds of the formula, IIa, ##STR1## wherein: Y is hydrogen or lower alkyl; and Z is a lower alkoxy substituted quinolinylamino radical, a cyano substituted pyrazolylamino radical or a mono- or di-lower alkyl substituted thiazolamino radical, ora nitrogen-containing heterocyclic radical, ora cyano, phenyl, carboxamido or lower alkoxycarbonyl substituted 1-aziridinyl radical ora lower alkyl, formyl or acetylphenyl substituted 1-piperazinyl radical, oran hydroxy or piperidyl substituted 1-piperidyl radical, ora lower alkoxy, amino or halo substituted pyridylamino radical, ora carboxamido, mercapto or methylenedioxy substituted anilino radical, ora radical of the formula, ##STR2## wherein R is hydrogen or lower alkyl and R" is a nitrogen-containing heterocyclic radical, ora butyrolactonyl radical, oran adamantyl radical, ora mono- lower alkoxy substituted phenyl radical, ora substituted lower alkyl radical selected from the group consisting of mercapto lower alkyl, carboxy lower alkyl, mono-, dType: GrantFiled: December 15, 1983Date of Patent: October 14, 1986Assignee: University Patents, Inc.Inventor: William A. Remers
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Patent number: 4460599Abstract: Compounds of the formula, I, ##STR1## wherein: Y is hydrogen or lower alkyl; and X is a thiazolamino radical, a furfurylamino radical or a radical of the formula, ##STR2## in which R, R.sup.1, and R.sup.2 are the same or different and selected from the group consisting of hydrogen and lower alkyl, and R.sup.3 is selected from the group consisting of lower alkenyl, halo-lower alkenyl, lower alkynyl, lower akloxycarbonyl, thienyl, formamyl, tetrahydrofuryl and benzene sulfonamide.Also disclosed are novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula, Ia, ##STR3## wherein: Y is hydrogen or lower alkyl; and Z is a thiazolamino radical, a furfurylamino radical, a cyclopropylamino radical, a pyridylamino radical, or a radical of the formula, ##STR4## in which R.sup.4, R.sup.5, and R.sup.6 are the same or different and selected from the group consisting of hydrogen and lower alkyl, and R.sup.Type: GrantFiled: November 13, 1980Date of Patent: July 17, 1984Assignee: University Patents, Inc.Inventor: William A. Remers
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Patent number: 4268676Abstract: Compounds of the formula, I, ##STR1## wherein: Y is hydrogen or lower alkyl; and X is a thiazolamino radical, a furfurylamino radical or a radical of the formula, ##STR2## in which R, R.sup.1, and R.sup.2 are the same or different and selected from the group consisting of hydrogen and lower alkyl, and R.sup.3 is selected from the group consisting of lower alkenyl, halo-lower alkenyl, lower alkynyl, lower akloxycarbonyl, thienyl, formamyl, tetrahydrofuryl and benzene sulfonamide.Also disclosed are novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula, Ia, ##STR3## wherein: Y is hydrogen or lower alkyl; and Z is a thiazolamino radical, a furfurylamino radical, a cyclpropylamino radical, a pyridylamino radical, or a radical of the formula, ##STR4## in which R.sup.4, R .sup.5, and R.sup.6 are the same or different and selected from the group consisting of hydrogen and lower alkyl, and R.sup.Type: GrantFiled: December 5, 1979Date of Patent: May 19, 1981Assignee: University Patents, Inc.Inventor: William A. Remers