Patents by Inventor William A. Segraves

William A. Segraves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor
    Patent number: 7119077
    Abstract: In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to transactivate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: October 10, 2006
    Assignee: The Salk Institute for Biological Studies
    Inventors: Ronald M. Evans, Michael B. McKeown, Anthony E. Oro, William A. Segraves, Tso-Pang Yao
  • Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor
    Patent number: 6281330
    Abstract: In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to transactivate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 28, 2001
    Assignee: The Salk Institute Biological Studies
    Inventors: Ronald M. Evans, Michael B. Mc Keown, Anthony E. Oro, William A. Segraves, Tso-Pang Yao
  • Methods of modulating the expression of genes using ultraspiracle receptor
    Patent number: 6265173
    Abstract: In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to trans-activate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: July 24, 2001
    Assignee: The Salk Institute for Biological Studies
    Inventors: Ronald M. Evans, Michael B. Mc Keown, Anthony E. Oro, William A. Segraves, Tso-Pang Yao
  • Polynucleotides encoding insect steroid hormone receptor polypeptides and cells transformed with same
    Patent number: 5514578
    Abstract: Polynucleotide sequences which encode ecdysone receptors have been isolated and expressed in host cells.
    Type: Grant
    Filed: September 30, 1992
    Date of Patent: May 7, 1996
    Assignee: The Board of Trustees of Leland Stanford University
    Inventors: David S. Hogness, Michael R. Koelle, William A. Segraves