Abstract: This invention concerns the use of a compound of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z is halo; C1-6alkyl; C1-6alkyl substituted with hydroxy, carboxyl, cyano, amino, mono- or di(C1-6alkyl)amino, aminocarbonyl, mono- or di(C1-6alkyl)aminocarbonyl, C1-6alkyloxycarbonyl or C1-6alkyloxy; polyhaloC1-4alkyl; C1-4alkyloxy; cyano; amino; aminocarbonyl; mono- or di(C1-6alkyl)aminocarbonyl; C1-6alkyloxycarbonyl; C1-6alkylcarbonyloxy; H2N—S(?O)2—; mono- or di(C1-6alkyl)amino-S(?O)2; —C(?N—Rx)NRyRz; Q is an optionally substituted carbocycle or an optionally substituted heterocycle; L is substituted phenyl or an optionally substituted monocyclic 5 or 6-membered partially saturated or aromatic heterocycle or a bicyclic partially saturated or aromatic heterocycle; aryl is optionally substituted phenyl; for the manufacture of a medicament for the prevention or the treatment of diseases mediated through TNF-? and/or I

Abstract: This invention concerns the use of a compound of formula (I) 1

Abstract: Disclosed is the use of Sc.sup.2+ based active crystalline luminescent media for laser systems, tunable in the UV-visible spectral range. The crystalline media are Sc-doped alkali-earth-halide crystals such as: (1) alkali-earth-halide combinations, such as MeF.sub.2, MeCl.sub.2,crystals; (2) mixed alkali-earth metal fluorides and chlorides, such as MeFCl, M.sub.x Me.sub.1-x F.sub.2 and M.sub.x Me.sub.1-x Cl.sub.2 crystals; and (3) complex fluoride crystals; wherein M and Me are Ca, Sr, Ba or Mg. These crystals have Sc.sup.2+ ion impurities providing stable optical centers that yield advantageous luminescent properties. The base crystal structure utilized determines the luminescent emission spectrum for the Sc.sup.2+ optical centers. By manipulating the base crystal, the maxima of the absorption and emission bands may be altered from UV-blue to red in the optical spectrum. The Sc.sup.2+ active crystalline luminescent media are initially doped with trivalent Sc.sup.3+ ions during crystal growth.