Abstract: The invention provides certain difluorocyclohexyl-imidazopyridazinyl-imidazolidinone compounds of formula II as IL-17A inhibitors, pharmaceutical compositions thereof, and methods of using a compound of formula II to treat certain symptoms of psoriasis, rheumatoid arthritis or multiple sclerosis.

Abstract: Disclosed herein are methods of disrupting cell-to-cell communication. An exemplary method comprises transmitting one or more microwave signals to a communication molecule located in an environment having a plurality of cells. The one or more microwave signals can comprise a first microwave signal and a second microwave signal. The first microwave signal can have a first frequency corresponding to frequency of a first peak in a microwave spectrum associated with rotational modes of the communication molecule. The second microwave signal can have a second frequency corresponding to a frequency of a second peak in the microwave spectrum associated with the rotational modes of the communication molecule.

Abstract: The invention relates to a kit for refilling an implantable pump and, more particularly, to packaging and contents of a kit to improve the workflow of a user while adding medication to an implantable pump that has been surgically implanted in a patient. kit for refilling an implanted pump. The kit comprises a setup tray containing at least one needle, a fenestrated drape, a first syringe, a needle, a filter, and clampable tubing; and a medication tray containing a second syringe, at least one ampule of medication, an ampule opener, and aspiration tubing. The medication tray is molded to have a recess that securely holds the at least one ampule in both a horizontal position and in a vertical position.

Abstract: A compression device for freeing a ring trapped on a digit includes a rigid outer body. The rigid outer body includes a digit cavity extending from a cavity opening at a body proximal end of the body towards a body distal end of the body, a fluid inlet, and a fluid flow path fluidly connecting the fluid inlet to one or more inflation chambers positioned in the digit cavity. The body proximal end includes an upper portion, a lower portion, and two laterally spaced-apart side portions. At least one side portion is distally recessed as compared to the upper and lower portions to accommodate an interdigital fold. At least one flexible bladder lines the digit cavity, each flexible bladder defining at least one wall of one of the one or more inflation chambers.

Abstract: Techniques for altering audio being output by a voice-controlled device, or another device, to enable more accurate automatic speech recognition (ASR) by the voice-controlled device. For instance, a voice-controlled device may output audio within an environment using a speaker of the device. While outputting the audio, a microphone of the device may capture sound within the environment and may generate an audio signal based on the captured sound. The device may then analyze the audio signal to identify speech of a user within the signal, with the speech indicating that the user is going to provide a subsequent command to the device. Thereafter, the device may alter the output of the audio (e.g., attenuate the audio, pause the audio, switch from stereo to mono, etc.) to facilitate speech recognition of the user's subsequent command.

Abstract: A chatbot system for an interactive platform is disclosed. The chatbot system retrieves a conversation history of one or more conversations between a user and a chatbot from a conversation history datastore and generates one or more summarized memories using the conversation history. One or more moderated memories are generated using the summarized memories. The moderated memories are stored in a memories datastore. A user prompt is received, and a current conversation context is generated from a current conversation between the user and the chatbot. One or more memories are retrieved from the memories datastore using the current conversation context. An augmented prompt is generated using the user prompt and the one or more memories, which is communicated to a generative AI model. A response is received from the generative AI model to the augmented prompt, which is provided to the user.

Abstract: A system for including a chatbot into a group chat session is provided. The system receives a chatbot mention message from a user in the group chat session. The chatbot mention message includes a chatbot prompt for a chatbot. The system generates a prompt using the chatbot mention message and communicates the response as a chatbot response message to each user in the group chat session.

Abstract: A chatbot system for filtering conversation content. A chatbot system receives, from a client system, a prompt of a user during an interactive session. The chatbot system filters the prompt of the user based on a set of platform policies and generates a response based on the filtering of the prompt of the user, and communicates the response to the client system.

Abstract: A system includes: an acoustic exciter, a compliant material applied to the acoustic exciter to configure the acoustic exciter for triggering acoustic excitation of at least part of a substrate; a sensor configured to receive an acoustic response of the acoustic excitation; and circuitry configured to determine at least one characteristic of the substrate using the acoustic response.

Abstract: A method of disinfecting using a light diffusing fiber includes optically coupling a light source to a light diffusing optical fiber having a core, a cladding surrounding the core, an outer surface, and a plurality of scattering structures positioned within the core, the cladding, or both the core and the cladding. The method further includes positioning the light diffusing optical fiber in optical engagement with a pathogen sample and directing light output by the light source into the light diffusing optical fiber for a first time interval. The scattering structures scatter light propagating along the light diffusing optical fiber toward the outer surface and a portion of the light diffuses through the outer surface thereby irradiating the pathogen sample with light having an average power density of about 5 mW/cm2 to about 30 mW/cm2 at a wavelength from about 380 nm to about 495 nm for an exposure time from about 2 hours to about 24 hours.

Abstract: This disclosure describes architectures and techniques to provide information to a user about items with which the user interacts. In some instances, a user may utilize a wearable device that is configured to interact with one or more components of an information discovery system to obtain information about items in the user's environment.

Abstract: A method of disinfecting using a light diffusing fiber includes optically coupling a light source to a light diffusing optical fiber having a core, a cladding surrounding the core, an outer surface, and a plurality of scattering structures positioned within the core, the cladding, or both the core and the cladding. The method further includes positioning the light diffusing optical fiber in optical engagement with a pathogen sample and directing light output by the light source into the light diffusing optical fiber for a first time interval. The scattering structures scatter light propagating along the light diffusing optical fiber toward the outer surface and a portion of the light diffuses through the outer surface thereby irradiating the pathogen sample with light having an average power density of about 5 mW/cm2 to about 30 mW/cm2 at a wavelength from about 380 nm to about 495 nm for an exposure time from about 2 hours to about 24 hours.

Abstract: A sterile solution product bag for lyophilizing includes a bladder, a first stem having a first stem inlet end and a first stem outlet end. The first stem outlet end is fluidly connected to the bladder and the first stem inlet end is adapted to receive a liquid. A first filter is disposed in-line with the first stem and includes a first filter membrane, a first filter open end, and a first filter closed end. The first filter closed end is disposed between the first stem inlet end and the first stem outlet end and the first filter open end is disposed in proximity to the first stem inlet end. A second stem having a second stem inlet end fluidly connected to the bladder and a second stem outlet end adapted to receive a vapor. A second filter is disposed within the second stem and includes a filter membrane.

Abstract: A therapeutic illumination assembly includes a catheter and a point source treatment fiber. The catheter comprises a catheter wall encircling a luminal fluid pathway. The point source treatment fiber is positioned within the luminal fluid pathway of the catheter. Further, the point source treatment fiber comprises a plurality of light emitting point sources intermittently positioned along a treatment length of the point source treatment fiber such that the plurality of light emitting point sources irradiate the catheter when the plurality of light emitting point sources emit light.

Abstract: Noise that is present in the output of a weight sensor can lead to erroneous weight data. A moveable device, such as a tote, may be used by a customer while shopping in a facility. This tote can include one or more weight sensors that are used to determine the weight of items added to or removed from the tote. However, noise can affect the output of the weight sensors, where such noise is attributed to movement or vibration of the tote. Data from a vibration sensor or a motion sensor coupled to the tote can be analyzed to determine noise that is common to weight data and vibration data or motion data associated with the tote. This common noise can then be removed or attenuated from the weight signals to determine de-noised and valid weight data for the tote.

Abstract: Various embodiments of an apparatus, methods, systems and computer program products described herein are directed to detecting initiation of one or more shared libraries being loaded into a runtime memory of an application. While the one or more shared libraries are being loaded into the runtime memory, randomization code is placed into the runtime memory. For each respective shared library loaded into the runtime memory: randomization code allocates a new segment of runtime memory. The randomization code inserts a copy of the shared library into the new segment of runtime memory and overwrites a current segment of runtime memory at which the shared library is currently stored.

Abstract: Disclosed are embodiments of a method for affecting thrombi formation on an indwelling catheter. The method involves the step of providing an intravenous catheter. The intravenous catheter includes an inner surface and an outer surface, and the intravenous catheter is located within a blood vessel. A light diffusing element is inserted into the intravenous catheter. Light is emitted from the light diffusing element such that the light irradiates the intravenous catheter. The light emitted from the light diffusing element is configured to promote or hinder thrombi formation on the inner surface or outer surface of the intravenous catheter. Also disclosed are an illumination system for affecting thrombi formation on an intravenous catheter as well as an indwelling intravenous catheter system.

Abstract: A method of mixing a pharmaceutical solution including adding a gas into an interior compartment of a mix bag to form a headspace. The interior compartment of the mix bag includes a top portion and a bottom portion. The headspace adjacent to the top portion contains gas. The method includes adding a solvent into the mix bag, and establishing a bubble column in the interior compartment by activating a recirculation assembly. The recirculation assembly includes a connecting pathway operably coupled to a recirculation pump. A first end of the connecting pathway is coupled to a top gas recirculation port and a second end is coupled to a bottom gas recirculation port of the mix bag such that the recirculation pump draws the gas from the headspace and delivers the gas to the interior compartment via the bottom gas recirculation port. The method includes adding a solute into the mix bag.

Abstract: A system includes: an acoustic exciter; a compliant material applied to the acoustic exciter to configure the acoustic exciter for triggering acoustic excitation of at least part of a substrate; a sensor configured to receive an acoustic response of the acoustic excitation; and circuitry configured to determine at least one characteristic of the substrate using the acoustic response.

Abstract: A product bag includes a bladder and an elongated filtration device. The bladder includes opposing first and second film layers defining a product chamber. The first and second film layers are sealed together along a perimeter seal extending along at least a portion of a perimeter of the bladder. The elongated filtration device includes a housing, a filtration membrane disposed in the housing, an inlet adapted for receiving a fluid to be filtered, and an outlet in fluid communication with the product chamber. A majority of the elongated filtration device is embedded between the first and second film layers of the perimeter seal of the bladder to provide for a compact form factor.